公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 |
2007 | Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus | Yang, Cheng-Wei; Yang, Yung-Ning; Liang, Po-Huang; Chen, Chi-Min; Chen, Wei-Liang; Chang, Hwan-You; Chao, Yu-Sheng; Lee, Shiow-Ju | Antimicrobial Agents and Chemotherapy | 14 | 15 | |
2006 | Pharmacophores and biological activities of severe acute respiratory syndrome viral protease inhibitors | Wang, Hui-Min; Liang, Po-Huang | Expert Opinion on Therapeutic Patents | | | |
2003 | Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli | Guo, Rey-Ting; Ko, Tzu-Ping; Chou, Chia-Cheng; Shr, Hui-Lin; Chu, Hsing-Mao; Tsai, Yao-Hsien; Liang, Po-Huang; Wan, Andrew H.-J. | Acta Crystallographica Section D: Biological Crystallography 59: | | | |
2002 | Probing the Conformational Change of Escherichia coli Undecaprenyl Pyrophosphate Synthase during Catalysis Using an Inhibitor and Tryptophan Mutants | Chen, Yi-Hung; Chen, Annie P.-C.; Chen, Chao-Tsen ; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | 40 | 36 | |
2002 | Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzyme | Kuo, Tun-Hsun; Liang, Po-Huang | Biochimica et Biophysica Acta | | | |
2006 | Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease | Wu, Chung-Yi; King, Ke-Yung; Kuo, Chih-Jung; Fang, Jim-Min ; Wu, Ying-Ta; Ho, Ming-Yi; Liao, Chung-Lin; Shie, Jiun-Jie; Liang, Po-Huang; Wong, Chi-Huey | Chemistry & Biology | 104 | 107 | |
2009 | Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds | Lee, Cheng-Chung; Kuo, Chih-Jung; Ko, Tzu-Ping; Hsu, Min-Feng; Tsui, Yao-Chen; Chang, Shih-Cheng; Yang, Syaulan; Chen, Shu-Jen; Chen, Hua-Chien; Hsu, Ming-Chu; Shih, Shin-Ru; Liang, Po-Huang; Wang, Andrew H.-J. | Journal of Biological Chemistry | 103 | 97 | |
2007 | Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors | Shao, Yi-Ming; Yang, Wen-Bin; Peng, Hung-Pin; Hsu, Min-Feng; Tsai, Keng-Chang; Kuo, Tun-Hsun; Wang, Andrew H.-J.; Liang, Po-Huang; Lin, Chun-Hung; Yang, An-Suei; Wong, Chi-Huey | ChemBioChem | 32 | 27 | |
2006 | Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease | Lu, I-Lin; Mahindroo, Neeraj; Liang, Po-Huang; Peng, Yi-Hui; Kuo, Chih-Jung; Tsai, Keng-Chang; Hsieh, Hsing-Pang; Chao, Yu-Sheng; Wu, Su-Ying | Journal of Medicinal Chemistry | | | |
2008 | Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases | Kuo, Chih-Jung; Guo, Rey-Ting; Lu, I-Lin; Liu, Hun-Ge; Wu, Su-Ying; Ko, Tzu-Ping; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biomedicine and Biotechnology | 34 | 36 | |
2004 | Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studies | Chang, Sing-Yang; Ko, Tzu-Ping; Chen, Annie P.-C.; Wang, Andrew H.-J.; Liang, Po-Huang | Protein Science | | | |
2002 | Synthesis and Application of A Fluorescent Substrate Analogue to Study Ligand Interactions for Undecaprenyl Pyrophosphate Synthase | Chen, Annie P.-C.; Chen, Yi-Hung; Liu, Hsiao-Pei; Li, Yu-Chin; Chen, Chao-Tsen ; Liang, Po-Huang | Journal of the American Chemical Society | 40 | 36 | |
2023 | Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors | Palla, Srinivasa Rao; Li, Chen-Wei; TAI-LING CHAO ; Lo, Hoi-Ling Vienn; Liu, Jia-Jin; Pan, Max Yu-Chen; Chiu, Yu-Ting; Lin, Wen-Chin; Hu, Chih-Wei; Yang, Chuen-Mi; Chen, Yi-Ying; Fang, Jun-Tung; Lin, Sheng-Wei; Lin, Yi-Tzu; Lin, Hsiao-Ching; Kuo, Chih-Jung; Wang, Lily Hui-Ching; SUI-YUAN CHANG ; Liang, Po-Huang | Antiviral research | 0 | 0 | |
2021 | Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing | Pathak, Nikhil; Chen, Yun-Ti; Hsu, Yen-Chao; Hsu, Nung-Yu; Kuo, Chih-Jung; Tsai, Hui Ping; Huang, Chih-Heng; SUI-YUAN CHANG ; Chang, Yu-Hsiu; Liang, Po-Huang; Yang, Jinn-Moon; JAW-JOU KANG | ACS nano | 38 | 36 | |
2009 | 建構具阿拉伯呋喃醣酶與木聚醣酶活性之雙功能酵素之特性研究以及其分解半纖維素於製造生質能源之應用 | 李佩芸; Lee, Pei-Yun | | | | |
2009 | 改造嗜熱菌株之纖維素水解酶與甘露糖水解酶並研究其酵素特性以及分解纖維素產生生質能之應用 | 鍾雯州; Jung, Wen-Jou | | | | |
2009 | 病毒3C及3C-Like蛋白酶的鑑定、抑制和改造 | 郭致榮; Kuo, Chih-Jung | | | | |