公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 |
2008 | Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease | Shao, Yi-Ming; Yang, Wen-Bin; Kuo, Tun-Hsun; Tsai, Keng-Chang; Lin, Chun-Hung; Yang, An-Suei; Liang, Po-Huang; Wong, Chi-Huey | Bioorganic & Medicinal Chemistry | 64 | 56 | |
2009 | Different reaction mechanisms for cis- and trans-prenyltransferases | Lu, Yen-Pin; Liu, Hun-Ge; Liang, Po-Huang | Biochemical and Biophysical Research Communications | 31 | 28 | |
2007 | Drug discovery for SARS and other human coronaviruses targeting 3C proteases | Liang, Po-Huang | Drugs of the Future | | | |
2022 | Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets | Yu, Pei-Chen; Huang, Chen-Hao; Kuo, Chih-Jung; Liang, Po-Huang; Wang, Lily Hui-Ching; Pan, Max Yu-Chen; SUI-YUAN CHANG ; TAI-LING CHAO ; Ieong, Si-Man; Fang, Jun-Tung; Huang, Hsuan-Cheng; HSUEH-FEN JUAN | Pharmaceutics | 5 | 4 | |
2006 | An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin | Lee, Yuan-Yu; Hu, Hsiao-Tin; Liang, Po-Huang; Chak, Kin-Fu | Biochemical and Biophysical Research Communications | | | |
2005 | Homodimeric Hexaprenyl Pyrophosphate Synthase from the Thermoacidophilic Crenarchaeon Sulfolobus solfataricus Displays Asymmetric Subunit Structures | Sun, Han-Yu; Ko, Tzu-Ping; Kuo, Chih-Jung; Guo, Rey-Ting; Chou, Chia-Cheng; Liang, Po-Huang; Wang, Andrew H.-J. | Journal of Bacteriology | 28 | 26 | |
2008 | Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation | Chen, Cammy K.-M.; Hudock, Michael P.; Zhang, Yonghui; Guo, Rey-Ting; Cao, Rong; No, Joo Hwan; Liang, Po-Huang; Ko, Tzu-Ping; Chang, Tao-Hsin; Chang, Shiou-chi; Song, Yongcheng; Axelson, Jordan; Kumar, Anup; Wang, Andrew H.-J.; Oldfield, Eric | Journal of Medicinal Chemistry | 65 | 67 | |
2002 | Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis | Pan, Jian-Jung; Kuo, Tun-Hsun; Chen, Yi-Kai; Yang, Lee-Wei; Liang, Po-Huang | Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | | | |
2021 | Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2 | Kuo, Chih-Jung; TAI-LING CHAO ; Kao, Han-Chieh; Tsai, Ya-Min; Liu, Yi-Kai; Wang, Lily Hui-Ching; Hsieh, Ming-Chang; SUI-YUAN CHANG ; Liang, Po-Huang | Antimicrobial agents and chemotherapy | 27 | 22 | |
2006 | Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping | Kuo, Tun-Hsun; Chuang, Shiao-Cheng; Chang, Sing-Yang; Liang, Po-Huang | Biochemical Journal | | | |
2001 | Mechanism of Product Chain Length Determination and the Role of a Flexible Loop in Escherichia coli Undecaprenyl-pyrophosphate Synthase Catalysis | Ko, Tzu-Ping; Chen, Yi-Kai; Robinson, Howard; Tsai, Pei-Chun; Gao, Yi-Gui; Chen, Annie P.-C.; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | | | |
2005 | Mechanism of the Maturation Process of SARS-CoV 3CL Protease | Hsu, Min-Feng; Kuo, Chih-Jung; Chang, Kai-Ti; Chang, Hui-Chuan; Chou, Chia-Cheng; Ko, Tzu-Ping; Shr, Hui-Lin; Chang, Gu-Gang; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | 215 | 196 | |
2004 | A Molecular Ruler for Chain Elongation Catalyzed by Octaprenyl Pyrophosphate Synthase and Its Structure-Based Engineering To Produce Unprecedented Long Chain trans-Prenyl Products | Guo, Rey-Ting; Kuo, Chih-Jung; Ko, Tzu-Ping; Chou, Chia-Cheng; Liang, Po-Huang; Wang, Andrew H.-J. | Biochemistry | | | |
2007 | Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus | Yang, Cheng-Wei; Yang, Yung-Ning; Liang, Po-Huang; Chen, Chi-Min; Chen, Wei-Liang; Chang, Hwan-You; Chao, Yu-Sheng; Lee, Shiow-Ju | Antimicrobial Agents and Chemotherapy | 14 | 15 | |
2006 | Pharmacophores and biological activities of severe acute respiratory syndrome viral protease inhibitors | Wang, Hui-Min; Liang, Po-Huang | Expert Opinion on Therapeutic Patents | | | |
2003 | Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli | Guo, Rey-Ting; Ko, Tzu-Ping; Chou, Chia-Cheng; Shr, Hui-Lin; Chu, Hsing-Mao; Tsai, Yao-Hsien; Liang, Po-Huang; Wan, Andrew H.-J. | Acta Crystallographica Section D: Biological Crystallography 59: | | | |
2002 | Probing the Conformational Change of Escherichia coli Undecaprenyl Pyrophosphate Synthase during Catalysis Using an Inhibitor and Tryptophan Mutants | Chen, Yi-Hung; Chen, Annie P.-C.; Chen, Chao-Tsen ; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | 40 | 36 | |
2002 | Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzyme | Kuo, Tun-Hsun; Liang, Po-Huang | Biochimica et Biophysica Acta | | | |
2006 | Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease | Wu, Chung-Yi; King, Ke-Yung; Kuo, Chih-Jung; Fang, Jim-Min ; Wu, Ying-Ta; Ho, Ming-Yi; Liao, Chung-Lin; Shie, Jiun-Jie; Liang, Po-Huang; Wong, Chi-Huey | Chemistry & Biology | 104 | 107 | |
2009 | Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds | Lee, Cheng-Chung; Kuo, Chih-Jung; Ko, Tzu-Ping; Hsu, Min-Feng; Tsui, Yao-Chen; Chang, Shih-Cheng; Yang, Syaulan; Chen, Shu-Jen; Chen, Hua-Chien; Hsu, Ming-Chu; Shih, Shin-Ru; Liang, Po-Huang; Wang, Andrew H.-J. | Journal of Biological Chemistry | 103 | 97 | |