公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 |
2007 | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases | Guo, Rey-Ting; Cao, Rong; Liang, Po-Huang; Ko, Tzu-Ping; Chang, Tao-Hsin; Hudock, Michael P.; Jeng, Wen-Yih; Chen, Cammy K.-M.; Zhang, Yonghui; Song, Yongcheng; Kuo, Chih-Jung; Yin, Fenglin; Oldfield, Eric; Wang, Andrew H.-J. | Proceedings of the National Academy of Sciences | 150 | 153 | |
2006 | Characterization and inhibition of SARS-coronavirus main protease | Liang, Po-Huang | Current Topics in Medicinal Chemistry | | | |
2009 | Corrigendum to “Individual and common inhibitors of coronavirus and picornavirus main proteases” [FEBS Lett. 583 (2009) 549–555] | Kuo, Chih-Jung; Liu, Hun-Ge; Lo, Yueh-Kuei; Seong, Churl-Min; Lee, Kee-In; Jung, Young-Sik; Liang, Po-Huang | FEBS Letters | | | |
2006 | The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin producing Escherichia coli | Pan, Yi-Hsuan; Liao, Chen-Chung; Kuo, Chou-Chiang; Duan, Kow-Jen; Liang, Po-Huang; Yuan, Hanna S.; Hu, Shiau-Ting; Chak, Kin-Fu | The Journal of Biological Chemistry | | | |
2004 | Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination | Guo, Rey-Ting; Kuo, Chih-Jung; Chou, Chia-Cheng; Ko, Tzu-Ping; Shr, Hui-Lin; Liang, Po-Huang; Wang, Andrew H.-J. | Journal of Biological Chemistry | | | |
2006 | Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase from Saccharomyces cerevisiae and the Mechanism of Product Chain Length Determination | Chang, Tao-Hsin; Guo, Rey-Ting; Ko, Tzu-Ping; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | | | |
2005 | Crystal Structures of Undecaprenyl Pyrophosphate Synthase in Complex with Magnesium, Isopentenyl Pyrophosphate, and Farnesyl Thiopyrophosphate-ROLES OF THE METAL ION AND CONSERVED RESIDUES IN CATALYSIS | Guo, Rey-Ting; Ko, Tzu-Ping; Chen, Annie P.-C.; Kuo, Chih-Jung; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | 104 | 99 | |
2008 | Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease | Shao, Yi-Ming; Yang, Wen-Bin; Kuo, Tun-Hsun; Tsai, Keng-Chang; Lin, Chun-Hung; Yang, An-Suei; Liang, Po-Huang; Wong, Chi-Huey | Bioorganic & Medicinal Chemistry | 64 | 56 | |
2009 | Different reaction mechanisms for cis- and trans-prenyltransferases | Lu, Yen-Pin; Liu, Hun-Ge; Liang, Po-Huang | Biochemical and Biophysical Research Communications | 31 | 28 | |
2007 | Drug discovery for SARS and other human coronaviruses targeting 3C proteases | Liang, Po-Huang | Drugs of the Future | | | |
2022 | Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets | Yu, Pei-Chen; Huang, Chen-Hao; Kuo, Chih-Jung; Liang, Po-Huang; Wang, Lily Hui-Ching; Pan, Max Yu-Chen; SUI-YUAN CHANG ; TAI-LING CHAO ; Ieong, Si-Man; Fang, Jun-Tung; Huang, Hsuan-Cheng; HSUEH-FEN JUAN | Pharmaceutics | 5 | 4 | |
2006 | An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin | Lee, Yuan-Yu; Hu, Hsiao-Tin; Liang, Po-Huang; Chak, Kin-Fu | Biochemical and Biophysical Research Communications | | | |
2005 | Homodimeric Hexaprenyl Pyrophosphate Synthase from the Thermoacidophilic Crenarchaeon Sulfolobus solfataricus Displays Asymmetric Subunit Structures | Sun, Han-Yu; Ko, Tzu-Ping; Kuo, Chih-Jung; Guo, Rey-Ting; Chou, Chia-Cheng; Liang, Po-Huang; Wang, Andrew H.-J. | Journal of Bacteriology | 28 | 26 | |
2008 | Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation | Chen, Cammy K.-M.; Hudock, Michael P.; Zhang, Yonghui; Guo, Rey-Ting; Cao, Rong; No, Joo Hwan; Liang, Po-Huang; Ko, Tzu-Ping; Chang, Tao-Hsin; Chang, Shiou-chi; Song, Yongcheng; Axelson, Jordan; Kumar, Anup; Wang, Andrew H.-J.; Oldfield, Eric | Journal of Medicinal Chemistry | 65 | 67 | |
2002 | Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis | Pan, Jian-Jung; Kuo, Tun-Hsun; Chen, Yi-Kai; Yang, Lee-Wei; Liang, Po-Huang | Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | | | |
2021 | Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2 | Kuo, Chih-Jung; TAI-LING CHAO ; Kao, Han-Chieh; Tsai, Ya-Min; Liu, Yi-Kai; Wang, Lily Hui-Ching; Hsieh, Ming-Chang; SUI-YUAN CHANG ; Liang, Po-Huang | Antimicrobial agents and chemotherapy | 27 | 22 | |
2006 | Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping | Kuo, Tun-Hsun; Chuang, Shiao-Cheng; Chang, Sing-Yang; Liang, Po-Huang | Biochemical Journal | | | |
2001 | Mechanism of Product Chain Length Determination and the Role of a Flexible Loop in Escherichia coli Undecaprenyl-pyrophosphate Synthase Catalysis | Ko, Tzu-Ping; Chen, Yi-Kai; Robinson, Howard; Tsai, Pei-Chun; Gao, Yi-Gui; Chen, Annie P.-C.; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | | | |
2005 | Mechanism of the Maturation Process of SARS-CoV 3CL Protease | Hsu, Min-Feng; Kuo, Chih-Jung; Chang, Kai-Ti; Chang, Hui-Chuan; Chou, Chia-Cheng; Ko, Tzu-Ping; Shr, Hui-Lin; Chang, Gu-Gang; Wang, Andrew H.-J.; Liang, Po-Huang | Journal of Biological Chemistry | 215 | 196 | |
2004 | A Molecular Ruler for Chain Elongation Catalyzed by Octaprenyl Pyrophosphate Synthase and Its Structure-Based Engineering To Produce Unprecedented Long Chain trans-Prenyl Products | Guo, Rey-Ting; Kuo, Chih-Jung; Ko, Tzu-Ping; Chou, Chia-Cheng; Liang, Po-Huang; Wang, Andrew H.-J. | Biochemistry | | | |