The Relationship Betweem Follistatin and Low-Grade Chronic Inflammation in Women with Polycystic Ovary Syndrome

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Project title/計畫英文名

Project Number/計畫編號

NSC98-2314-B002-105-MY3

Translated Name/計畫中文名

卵泡抑制素與低度發炎反應在多囊性卵巢症候群婦女之相關性研究

Project Principal Investigator/計畫主持人

MEI-JOU CHEN

Funding Organization

National Science and Technology Council

Website

link

Start date/計畫起

01-08-2010

Expected Completion/計畫迄

12-07-2011

摘要：卵泡抑制素(follistatin) 除了在卵巢濾泡外，身體其他組織也都會分泌，被認為與造成多囊性卵巢症候群的婦女其卵巢濾泡停止生長的原因有關。也曾經被認為是多囊性卵巢症候群的婦女的指標基因。多囊性卵巢症候群的婦女其體內卵泡抑制素的含量較正常婦女為高，但是原因不明。近來發現卵泡抑制素與抗發炎反應有關，而多囊性卵巢症候群剛好是個有高慢性低度發炎反應與肥胖盛行率的疾病，可是關於卵泡抑制素、低度發炎反應與肥胖在多囊性卵巢症候群的婦女之間表現的研究闕如，因此ㄧ般所知不多。為了要進ㄧ歩了解肥胖、胰島素抗性、高雄性素血症(hyperandrogenemia)和慢性低度發炎反應(chronic low-grade inflammation)對於卵泡抑制素(follistatin)產生的影響為直接或間接的刺激或抑制。我們設計ㄧ個三年期的研究計畫，計劃去找出卵泡抑制素與低度發炎反應之相關性，並希望藉由體外細胞實驗，了解卵泡抑制素與低度發炎細胞激素在多囊性卵巢症候群所造成不排卵的致病機轉上所扮演的角色。並探討一般常見對於多囊性卵巢症候群的治療包括減重、避孕藥與胰島素敏感劑等，可否對於卵泡抑制素與低度發炎反應的產生造成影響。
Abstract: Follistatin is not only secreted from ovarian follicle, but also secreted from various tissuessuch as endothelial cell, liver cells and muscle cells etc, and has various important physiologicand developmental roles. Follistatin can act as an important regulator of folliculardevelopment and cellular function due to its ability to bind and neutralize activins and bonemorphogenetic proteins (BMPs). Overexpression of follistatin gene in transgenic miceresulted in infertility and arrest of ovarian folliculogenesis at early stage as seen in womenwith polycystic ovary syndrome (PCOS). Follistatin has been published to be a candidategene for women with PCOS by linkage analysis. Serum circulating follistatin levels wasreported to be higher in women with PCOS than those without PCOS. However, the roles ofhigh extragonadol origin follistatin secretion play in women with PCOS remain unknown. Ithas been reported that the serum follistatin levels may increase following bacterial compoundinduced inflammatory reactions. Women with PCOS were reported to have high prevalence oflow-grade inflammation comparing with those women without PCOS. But most of the studiesattribute this phenomenon to the high prevalence of obesity in women with PCOS. Studiesregarding to follistatin, hsCRP and obesity in women with PCOS are not yet available.Besides, how the low-grade inflammatory status of women with PCOS affects the ovulatoryfunction is also unknown. Therefore, we design this 3-year study including prospectivestudies with intervention and in-vitro studies to investigate the possible role of follistatin andlow-grade inflammatory cytokines plays in the pathogenesis of polycystic ovary syndrome.

Keyword(s)

多囊性卵巢症候群
卵泡抑制素
肥胖
胰島素抗性
高雄性素血症
慢性低度發炎反應
Polycystic ovary syndrome
follistatin
obesity
insulin resistance
inflammation
testosterone

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The Relationship Betweem Follistatin and Low-Grade Chronic Inflammation in Women with Polycystic Ovary Syndrome

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