Abstract
摘要：及實原前實原雖念字前接念雖記研釋及字記誌扮及前字原原字、字字觀、及實原前實原雖前項記部部扮及瘤字、念（扮及原記扮藥及萬原萬瘤記念、字及及字扮記記扮及、雖項扮前扮及念、及藥實前扮藥萬前前雖前字誌扮字前研藥前部研項字念、扮研接實項原前字前及實原前實原雖、部念原扮前前雖字誌扮字前研研學字前字前前雖字誌扮字、扮項字前扮字接念前藥、部原前前扮藥字記研字研字前前前雖藥前、念字瘤實扮字字字前接念實復瘤字前前及及機瘤藥前研研部原接實（、雖接念念部原前觀念字前扮及念部誌部雖記研念前接念、扮觀念字原研研字實復瘤及、字扮藥及及部及念扮藥萬部原記前字前雖部原、記字前接念實復瘤前字前及藥部、項扮扮字及實原前實原雖及、扮接實（部原前瘤誌前研念念念雖扮前雖實研前釋前研字部部萬前及實誌釋釋、字實項字前前研念項前觀字、字CD133 研實復瘤接念念部原瘤記念實及實原前實原雖原項實復瘤項扮扮研部藥研扮、念前部項念實研扮藥研釋、扮研扮前項前字部接扮、字扮釋部原字前項藥部前研復項前機瘤藥及字部實部釋前、研扮研念原項字原前字前扮研研念雖接念念部原字及實原前實原雖前字前及藥部記機扮誌前念扮、念扮扮接字及及項字瘤、及、字字誌字記前雖接念念部原前原瘤記、實雖扮瘤字項扮扮研部藥研扮、研念雖接念念部原念及實原前實原雖藥部前研復項前釋前、念及記扮接實實項學藥部前部及、及、復扮及實原前實原雖實項學藥部前機瘤藥、記扮研接實誌雖接念念部原研釋前部及、及、復扮接實雖接念念部原扮字前藥前念雖觀念前雖記萬前、扮部研萬實扮研念原項、記瘤項藥學研實雖記接念念部原前及實、扮念萬前雖記前雖藥前前研字誌前、念前藥雖記前字瘤前項、
Abstract: Colorectal carcinoma is a major cause of cancer related morbidity and mortality.In the western countries, it is the second leading cause of death from cancer. Inthe United States, there are with approximately 140,000 new cases and 50,000deaths per year. The incidence of colorectal cancer has increased in Taiwanrecently, with over 10,000 new cases and 4,000 mortalities per year. Despite theemergence of new biologic agents, availability of several new chemotherapeuticdrugs, and use of various combinations thereof, none of these treatmentmodalities is curative for patients with advanced colorectal cancer. This problemraises questions as to whether current systemic anti-colorectal cancer treatmentsare targeting molecular mechanisms or tumor cell populations that are trulycritical to cancer growth.It is gradually accepted that only a small fraction of cancer cells with theproperty of stem cells, known as cancer-initiating cells (CICs) , are responsiblefor tumor growth and metastasis. However, in colorectal cancers, markers ofcancer-initiating cells and its relationship with clinical outcomes are not clearlyunderstood. Our previous results showed the intensity of CD133, which is aproposed marker of CICs, immunohistochemistry (IHC) staining on the primarycolorectal tumor is associated with patients’ prognosis. But positive staining rateis not high enough. Also the mechanism by which these cells can inducemetastasis or recurrence is not so clear at present. In this project, we will try toinvestigate the role of cancer-initiating cells in colorectal cancer progression andmetastasis and achieve three aims, including 1. establish the connection betweenthe CICs and cancer metastasis or recurrence by IHC staining of candidate CICsurface markers on surgical specimens, especially focusing on peritonealcarcinomatosis in colorectal cancer patients; 2. find the mechanisms ofperitoneal carcinomatosis in terms of cancer-initiating cells and 3. screencandidate compounds and evaluate their therapeutic effects against colorectalcancer carcinomatosis. We hope the results of this project can increase theunderstanding of cancer-initiating cell and find new drugs or treatmentmodalities for cancer treatment, thus help mankind to overcome the deadly threatof cancer.
Keyword(s)
Small cell lung cancer
EGFR mutation
heterogeneity
cell lines
