Results 1-79 of 79 (Search time: 0.024 seconds).

Issue DateTitleAuthor(s)TypescopusWOSFulltext/Archive link
12020MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trialSarker, Debashis; Plummer, Ruth; Meyer, Tim; Sodergren, Mikael; Basu, Bristi; Chee, Cheng Ean; KAI-WEN HUANG ; Palmer, Daniel H; Ma, Yuk Ting; Evans, T R Jeffry; Spalding, Duncan Rc; Pai, Madhava; Sharma, Rohini; Pinato, David J; Spicer, James; Hunter, Sarah; Kwatra, Vineet; Nicholls, Joanna P; Collin, David; Nutbrown, Robert; Glenny, Helen; Fairbairn, Sonia; Reebye, Vikash; Voutila, Jon; Dorman, Stephanie; Andrikakou, Pinelopi; Lloyd, Peter; Felstead, Steve; Vasara, Jenni; Habib, Robert; Wood, Chris; Sætrom, Pål; Huber, Hans E; Blakey, David C; Rossi, John J; Habib, Nagyjournal article
22020Prognostic factor analysis of irreversible electroporation for locally advanced pancreatic cancer – A multi-institutional clinical study in AsiaYang P.-C.; KAI-WEN HUANG ; Pua U.; Kim M.-D.; Li S.-P.; Li X.-Y.; Liang P.-C.journal article
32020Immunological basis of genesis of hepatocellular carcinoma: Unique challenges and potential opportunities through immunomodulationJayant K.; Habib N.; KAI-WEN HUANG ; Podda M.; Warwick J.; Arasaradnam R.Review
42020Recent advances: The imbalance of immune cells and cytokines in the pathogenesis of hepatocellular carcinomaJayant K.; Habib N.; KAI-WEN HUANG ; Warwick J.; Arasaradnam R.Review
52020Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic ProfileKAI-WEN HUANG ; Reebye V.; Czysz K.; Ciriello S.; Dorman S.; Reccia I.; Lai H.-S.; Peng L.; Kostomitsopoulos N.; Nicholls J.; Habib R.S.; Tomalia D.A.; S?trom P.; Wilkes E.; Cutillas P.; Rossi J.J.; Habib N.A.journal article
62020Improved quantitative assessment of HBV-associated liver fibrosis using second-harmonic generation microscopy with feature selectionHsiao C.-Y.; Teng X.; Su T.-H.; Lee P.-H.; Kao J.-H.; KAI-WEN HUANG journal article
72019Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized MiceZhou J.; Li H.; Xia X.; Herrera A.; Pollock N.; Reebye V.; Sodergren M.H.; Dorman S.; Littman B.H.; Doogan D.; KAI-WEN HUANG ; Habib R.; Blakey D.; Habib N.A.; Rossi J.J.journal article
82019A prospective, multi-institution assessment of irreversible electroporation for treatment of locally advanced pancreatic adenocarcinoma: initial outcomes from the AHPBA pancreatic registryHolland M.M.; Bhutiani N.; Kruse E.J.; Weiss M.J.; Christein J.D.; White R.R.; KAI-WEN HUANG ; Martin R.C.G.; IIjournal article
92019Graptopetalum paraguayense inhibits liver fibrosis by blocking TGF-β signaling in vivo and in vitroHsu W.-H.; Liao S.-C.; Chyan Y.-J.; KAI-WEN HUANG ; Hsu S.-L.; Chen Y.-C.; Siu M.-L.; Chang C.-C.; Chung Y.-S.; Huang C.-Y.F.journal article
102019Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDACYoon S.; KAI-WEN HUANG ; Andrikakou P.; Vasconcelos D.; Swiderski P.; Reebye V.; Sodergren M.; Habib N.; Rossi J.J.journal article
112019Mechanisms involved in the activation of C/EBPα by small activating RNA in hepatocellular carcinomaZhao X.; Reebye V.; Hitchen P.; Fan J.; Jiang H.; S?trom P.; Rossi J.; Habib N.A.; KAI-WEN HUANG journal article
122018Magnetic tools for medical diagnosisChieh J.-J.; Liao S.-H.; Wang L.-M.; KAI-WEN HUANG ; Yang H.-C.; Horng chapter
132018Gene activation of CEBPA using saRNA: Preclinical studies of the first in human saRNA drug candidate for liver cancerReebye V.; KAI-WEN HUANG ; Lin V.; Jarvis S.; Cutilas P.; Dorman S.; Ciriello S.; Andrikakou P.; Voutila J.; Saetrom P.; Mintz P.J.; Reccia I.; Rossi J.J.; Huber H.; Habib R.; Kostomitsopoulos N.; Blakey D.C.; Habib N.A.journal article
142018Acoustic radiation force impulse US imaging: Liver stiffness in patients with chronic hepatitis B with and without antiviral therapySu T.-H.; Liao C.-H.; Liu C.-H.; KAI-WEN HUANG ; Tseng T.-C.; Yang H.-C.; Liu C.-J.; Chen P.-J.; Chen D.-S.; Kao J.-H.journal article
152018Comparison of Radiofrequency Ablation and Transarterial Chemoembolization for Hepatocellular Carcinoma in the Caudate LobeLee B.-C.; Liu K.-L.; Wu C.-H.; KAI-WEN HUANG ; Ho C.-M.; Hu R.-H.; Ho M.-C.; Wu Y.-M.; Lee P.-H.; Liang P.-C.journal article
162018The efficacy of combination of induction chemotherapy and irreversible electroporation ablation for patients with locally advanced pancreatic adenocarcinomaKAI-WEN HUANG ; Yang P.-C.; Pua U.; Kim M.-D.; Li S.-P.; Qiu Y.-D.; Song T.-Q.; Liang P.-C.journal article
172018A novel photodynamic therapy-based drug delivery system layered on a stent for treating cholangiocarcinomaLiang P.-C.; KAI-WEN HUANG ; Tung C.-C.; Chang M.-C.; Chang F.-Y.; Wong J.-M.; Chang Y.-T.journal article
182018A systematic review and meta-analysis comparing liver resection with the Rf-based device habib?-4X with the clamp-crush techniqueJayant K.; Sodergren M.H.; Reccia I.; Kusano T.; Zacharoulis D.; Spalding D.; Pai M.; Jiao L.R.; KAI-WEN HUANG Review
192018Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic ReductionWei P.-L.; Lee L.-T.; Tseng L.-M.; KAI-WEN HUANG journal article
202017Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosisSu T.-H.; Shiau C.-W.; Jao P.; Yang N.-J.; Tai W.-T.; Liu C.-J.; Tseng T.-C.; Yang H.-C.; Liu C.-H.; KAI-WEN HUANG ; Hu T.-C.; Huang Y.-J.; Wu Y.-M.; Chen L.-J.; Chen P.-J.; Chen D.-S.; Chen K.-F.; Kao J.-H.journal article
212017Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell GrowthYoon S.; KAI-WEN HUANG ; Reebye V.; Spalding D.; Przytycka T.M.; Wang Y.; Swiderski P.; Li L.; Armstrong B.; Reccia I.; Zacharoulis D.; Dimas K.; Kusano T.; Shively J.; Habib N.; Rossi J.J.journal article
222017Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic NanoparticlesKAI-WEN HUANG ; Chieh J.-J.; Yeh C.-K.; Liao S.-H.; Lee Y.-Y.; Hsiao P.-Y.; Wei W.-C.; Yang H.-C.; Horng H.-E.journal article
232017Characterizations of anti-alpha-fetoprotein- conjugated magnetic nanoparticles associated with alpha-fetoprotein for biomedical applicationsLiao S.-H.; Huang H.-S.; Chieh J.-J.; Su Y.-K.; Tong Y.-F.; KAI-WEN HUANG journal article
242017Keratin/chitosan UV-crosslinked composites promote the osteogenic differentiation of human adipose derived stem cellsLin Y.-H.; KAI-WEN HUANG ; Chen S.-Y.; Cheng N.-C.; Yu J.journal article
252017Impact of cavitron ultrasonic surgical aspirator (CUSA) and bipolar radiofrequency device (Habib-4X) based hepatectomy for hepatocellular carcinoma on tumour recurrence and diseasefree survivalKAI-WEN HUANG ; Lee P.-H.; Kusano T.; Reccia I.; Jayant K.; Habib N.journal article
262017Irreversible Electroporation: A Novel Ultrasound-guided Modality for Non-thermal Tumor AblationHsiao C.-Y.; KAI-WEN HUANG Review
272016Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth in VivoYoon S.; KAI-WEN HUANG ; Reebye V.; Mintz P.; Tien Y.-W.; Lai H.-S.; S?trom P.; Reccia I.; Swiderski P.; Armstrong B.; Jozwiak A.; Spalding D.; Jiao L.; Habib N.; Rossi J.J.journal article
282016Local Control by Radiofrequency Thermal Ablation Increased Overall Survival in Patients with Refractory Liver Metastases of Colorectal CancerYang P.-C.; Lin B.-R.; Chen Y.-C.; Lin Y.-L.; Lai H.-S.; KAI-WEN HUANG ; Liang J.-T.journal article
292016Irreversible electroporation in locally advanced pancreatic cancer: A call for standardization of energy deliveryMartin R.C.G.; II, Durham A.N.; Besselink M.G.; Iannitti D.; Weiss M.J.; Wolfgang C.L.; KAI-WEN HUANG journal article
302016Immunomagnetic reduction assay on des-gamma-carboxy prothrombin for screening of hepatocellular carcinomaChieh J.-J.; KAI-WEN HUANG ; Chuang C.P.; Wei W.C.; Dong J.J.; Lee Y.Y.journal article
312016Rapid and quantitative discrimination of tumour cells on tissue slicesKAI-WEN HUANG ; Chieh J.-J.; Liao S.-H.; Wei W.-C.; Hsiao P.-Y.; Yang H.-C.; Horng H.-E.journal article
322015Signal analysis and liver tumor discrimination by using a high-Tc SQUID-based low-field NMR system in hospitalLiao S.-H.; Chieh J.-J.; Chou Y.-T.; Wang M.-W.; Chen H.-H.; KAI-WEN HUANG ; Yang H.-C.; Horng H.-E.journal article
332015Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancerHsu W.-H.; Chang C.-C.; KAI-WEN HUANG ; Chen Y.-C.; Hsu S.-L.; Wu L.-C.; Tsou A.-P.; Lai J.-M.; Huang C.-Y.F.journal article
342015Novel Integration of an Ultrasound Probe and a Rotational-Scanning SQUID Biosusceptometer for Diagnosing Liver TumorsChieh J.J.; Lee Y.Y.; Wei W.C.; Hsiao P.Y.; KAI-WEN HUANG journal article
352015Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinomaLiang P.-C.; Lai H.-S.; Shih T.T.-F.; Wu C.-H.; KAI-WEN HUANG journal article
362015Micromachining NiTi tubes for use in medical devices by using a femtosecond laserHung C.-H.; Chang F.-Y.; Chang T.-L.; Chang Y.-T.; KAI-WEN HUANG ; Liang P.-C.journal article
372015Dual-imaging model of SQUID biosusceptometry for locating tumors targeted using magnetic nanoparticlesChieh J.-J.; KAI-WEN HUANG ; Lee Y.-Y.; Wei W.-C.journal article
382015Sub-tesla-field magnetization of vibrated magnetic nanoreagents for screening tumor markersChieh J.-J.; KAI-WEN HUANG ; Shi J.-C.journal article
392015Assaying Carcinoembryonic Antigens by Normalized Saturation MagnetizationKAI-WEN HUANG ; Chieh J.-J.; Shi J.-C.; Chiang M.-H.journal article
402015Hepatoesophageal fistula after radiofrequency ablation for hepatic metastasisYang S.-M.; KAI-WEN HUANG ; Huang P.-M.journal article
412014Erratum: Discriminating hepatocellular carcinoma in rats using a high-Tc SQUID detected nuclear resonance spectrometer in a magnetic shielding boxKAI-WEN HUANG ; Chen H.-H.; Yang H.-C.; Horng H.-E.; Liao S.-H.; Yang S.Y.; Chieh J.-J.; Wang L.-M.erratum
422014Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivoReebye V.; S?trom P.; Mintz P.J.; KAI-WEN HUANG ; Swiderski P.; Peng L.; Liu C.; Liu X.; Lindk?r-Jensen S.; Zacharoulis D.; Kostomitsopoulos N.; Kasahara N.; Nicholls J.P.; Jiao L.R.; Pai M.; Spalding D.R.; Mizandari M.; Chikovani T.; Emara M.M.; Haoudi A.; Tomalia D.A.; Rossi J.J.; Habib N.A.journal article
432014Exploiting human CD34+ stem cell-conditioned medium for tissue repairMintz P.J.; KAI-WEN HUANG ; Reebye V.; Nteliopoulos G.; Lai H.-S.; S?trom P.; Kasahara N.; Jensen S.; Pai M.; Gordon M.Y.A.; Marley S.B.; Behan R.; Spalding D.R.; Haoudi A.; Emara M.M.; Nicholls J.; Rossi J.J.; Habib N.A.journal article
442014Time-evolution contrast of target MRI using high-stability antibody functionalized magnetic nanoparticles: An animal modelKAI-WEN HUANG ; Yang S.Y.; Horng H.E.; Chieh J.J.; Chen H.H.; Wu C.C.; Chen J.H.; Lin I.T.; Yang C.C.; Yang H.C.journal article
452014Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: A feasibility study for clinical useYang C.-C.; Yang S.-Y.; Ho C.-S.; Chang J.-F.; Liu B.-H.; KAI-WEN HUANG journal article
462014The pilot experience upon surgical ablation of large liver tumor by microwave system with tissue permittivity feedback control mechanismLiang P.-C.; Lai H.-S.; Shih T.T.-F.; Wu C.-H.; KAI-WEN HUANG journal article
472014Clinicopathological and prognostic significances of EGFR, KRAS and BRAF mutations in biliary tract carcinomas in TaiwanChang Y.-T.; Chang M.-C.; KAI-WEN HUANG ; Tung C.-C.; Hsu C.; Wong J.-M.journal article
482014Theoretical and Experimental study of a circular imprint process for fabricating polylactide stentsTeng P.-T.; Chang F.-Y.; Lin M.-J.; Chang Y.-T.; Liang P.-C.; KAI-WEN HUANG conference paper
492014Micro cutting of biliary stent with nanosecond fiber laser systemTeng P.-T.; Chang F.-Y.; Chang Y.-T.; Liang P.-C.; KAI-WEN HUANG conference paper
502013A pilot study of hepatic arterial infusion of chemotherapy for patients with advanced hepatocellular carcinoma who have failed anti-angiogenic therapyShao Y.-Y.; Liang P.-C.; Wu Y.-M.; Huang C.-C.; KAI-WEN HUANG ; Cheng J.C.; Hsu C.-H.; Hsu C.; Cheng A.-L.; Lin Z.-Z.journal article
512013Optimization of the detection coil of high-Tc superconducting quantum interference device-based nuclear magnetic resonance for discriminating a minimum amount of liver tumor of rats in microtesla fieldsChen H.-H.; KAI-WEN HUANG ; Yang H.-C.; Horng H.-E.; Liao S.-H.journal article
522013Development for high-accuracy in vitro assay of vascular endothelial growth factor using nanomagnetically labeled immunoassayYang C.C.; KAI-WEN HUANG ; Yang S.Y.; Chen H.H.; Chen T.C.; Ho C.S.; Chang S.F.; Chieh J.J.; Horng H.E.; Hong C.Y.; Yang H.C.journal article
532013Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fieldsYang H.C.; KAI-WEN HUANG ; Liao S.H.; Horng H.E.; Chieh J.J.; Chen H.H.; Chen M.J.; Chen K.L.; Wang L.M.journal article
542013Molecule-assisted nanoparticle clustering effect in immunomagnetic reduction assayYang S.Y.; Chieh J.J.; KAI-WEN HUANG ; Yang C.C.; Chen T.C.; Ho C.S.; Chang S.F.; Chen H.H.; Horng H.E.; Hong C.Y.; Yang H.C.journal article
552013Anti-CEA-functionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivoKAI-WEN HUANG ; Chieh J.-J.; Lin I.-T.; Horng H.-E.; Yang H.-C.; Hong C.-Y.journal article
562013Femtosecond laser nonlinear ablation process of biliary nitinol stent for cholangiocarcinomaHung C.-H.; Chang F.-Y.; Chang T.-L.; Chang Y.-T.; KAI-WEN HUANG ; Liang P.-C.conference paper
572012Feasibility studies for assaying alpha-fetoprotein using antibody-activated magnetic nanoparticlesKAI-WEN HUANG ; Yang S.-Y.; Hong Y.-W.; Chieh J.-J.; Yang C.-C.; Horng H.-E.; Wu C.-C.; Hong C.-Y.; Yang H.-C.journal article
582012Characteristics of magnetic labeling on liver tumors with anti-alpha-fetoprotein-mediated Fe3O4 magnetic nanoparticlesKAI-WEN HUANG ; Chieh J.-J.; Horng H.-E.; Hong C.-Y.; Yang H.-C.journal article
592012Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rateKAI-WEN HUANG ; Chen H.-H.; Yang H.-C.; Horng H.-E.; Liao S.-H.; Chieh J.-J.; Yang Y.journal article
602012Calreticulin promotes tumor lymphocyte infiltration and enhances the antitumor effects of immunotherapy by up-regulating the endothelial expression of adhesion moleculesWang H.-T.; Lee H.-I.; Guo J.-H.; Chen S.-H.; Liao Z.-K.; KAI-WEN HUANG ; Torng P.-L.; Hwang L.-H.journal article
612012Discriminating Hepatocellular Carcinoma in Rats Using a High-Tc SQUID Detected Nuclear Resonance Spectrometer in a Magnetic Shielding BoxKAI-WEN HUANG ; Chen H.-H.; Yang H.-C.; Horng H.-E.; Liao S.-H.; Yang S.Y.; Chieh J.-J.; Wang L.-M.journal article
622012Anti-angiogenic therapy renders large tumors vulnerable to immunotherapy via reducing immunosuppression in the tumor microenvironmentChan S.-F.; Wang H.-T.; KAI-WEN HUANG ; Torng P.-L.; Lee H.-I.; Hwang L.-H.journal article
632012In Vivo Screening of Hepatocellular Carcinoma Using AC Susceptibility of Anti-Alpha Fetoprotein-Activated Magnetic NanoparticlesChieh J.-J.; KAI-WEN HUANG ; Lee Y.-D.; Horng H.-E.; Yang H.-C.; Hong C.-Y.journal article
642011Transient elastography to assess hepatic fibrosis in hemodialysis chronic hepatitis C patientsLiu C.-H.; Liang C.-C.; KAI-WEN HUANG ; Liu C.-J.; Chen S.-I.; Lin J.-W.; Hung P.-H.; Tsai H.-B.; Lai M.-Y.; Chen P.-J.; Chen J.-H.; Chen D.-S.; Kao J.-H.journal article
652011Exploration of the relationship between the tumor burden and the concentration of vascular endothelial growth factor in liver-cancer-bearing animals using immunomagnetic reduction assayKAI-WEN HUANG ; Yang S.Y.; Yu C.Y.; Chieh J.J.; Yang C.-C.; Horng H.-E.; Hong C.-Y.; Yang H.-C.; Wu C.-C.journal article
662011Gene expression-based chemical genomics identifies potential therapeutic drugs in hepatocellular carcinomaChen M.-H.; Yang W.-L.R.; Lin K.-T.; Liu C.-H.; Liu Y.-W.; KAI-WEN HUANG ; Chang P.M.-H.; Lai J.-M.; Hsu C.-N.; Chao K.-M.; Kao C.-Y.; Huang C.-Y.F.journal article
672011Low-Field nuclear magnetic resonance and magnetic resonance imaging using a high-tc squid for tumor detectionKAI-WEN HUANG ; Liao S.-H.; Yang H.-C.; Chen H.-H.; Horng H.-E.; Chen M.J.; Yang S.-Y.conference paper
682011In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticlesHong C.-Y.; Yang S.-Y.; KAI-WEN HUANG ; Horng H.-E.; Yang H.-C.conference paper
692010Combining antiangiogenic therapy with immunotherapy exerts better therapeutical effects on large tumors in a woodchuck hepatoma modelKAI-WEN HUANG ; Wu H.-L.; Lin H.-L.; Liang P.-C.; Chen P.-J.; Chen S.-H.; Lee H.-I.; Su P.-Y.; Wu W.-H.; Lee P.-H.; Hwang L.-H.; Chen D.-S.journal article
702010Characterization of tumors using high-Tc superconducting quantum interference device-detected nuclear magnetic resonance and imagingLiao S.-H.; KAI-WEN HUANG ; Yang H.-C.; Yen C.-T.; Chen M.J.; Chen H.-H.; Horng H.-E.; Yang S.Y.journal article
712010Surgery for Boerhaave's syndrome with esophageal varices: Report of a caseLi C.-Y.; Huang P.-M.; KAI-WEN HUANG ; Lee Y.-C.journal article
722008Minimizing abdominal wall damage during high-intensity focused ultrasound ablation by inducing artificial ascitesWu C.-C.; Chen W.-S.; Ho M.-C.; KAI-WEN HUANG ; Chen C.-N.; Yen J.-Y.; Lee P.-H.journal article
732008Dual therapeutic effects of interferon-α gene therapy in a rat hepatocellular carcinoma model with liver cirrhosisKAI-WEN HUANG ; Huang Y.-C.; Tai K.-F.; Chen B.-H.; Lee P.-H.; Hwang L.-H.journal article
742007Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumorsChang C.-J.; Chen Y.-H.; KAI-WEN HUANG ; Cheng H.-W.; Chan S.-F.; Tai K.-F.; Hwang L.-H.journal article
752007Enterolith ileus in a patient with jejunal diverticulosis: Sonographic findingsLiu C.-H.; KAI-WEN HUANG ; Mo Y.-H.; Yang P.-M.journal article
762006Jejunojejunal intussusception secondary to a jejunal lipoma in an adult [3]Chiang T.-H.; Chang C.-Y.; KAI-WEN HUANG ; Liou J.-M.; Lin J.-T.; Wang H.-P.letter
772006Gene expression analysis of human hepatocellular carcinoma by using full-length cDNA libraryTsai C.-C.; KAI-WEN HUANG ; Chen H.-F.; Zhan B.-W.; Lai Y.-H.; Lee F.-H.; Lin C.-Y.; Ho Y.-C.; Chao Y.-W.; Su Y.-C.; Jane S.-W.; Chen Y.-C.; Hsu C.-I.; Li P.-H.; Hsu H.-C.; Suzuki Y.; Sugano S.; Lin J.-Y.journal article
782006Comparison of angiogenic factor levels in tumor drainage and peripheral venous blood from colorectal cancer patientsTien Y.-W.; Chang K.-J.; Chiu Y.-F.; KAI-WEN HUANG ; Lee P.-H.journal article
792003Hepatic encephalopathy and cerebral blood flow improved by liver dialysis treatmentKAI-WEN HUANG ; Chao A.; Chou N.-K.; Ko W.-J.journal article