研究成果


第 1 到 42 筆結果，共 42 筆。

公開日期標題作者來源出版物scopusWOS全文
12024Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteriaChen, Ling-Han; Lin, Man-Yi; Lin, Hsueh-Chun; Yang, Fan-Wei; Liao, Hsiao-Wei; Shiau, Chung-Wai; HAO-CHIEH CHIU ; Su, Jung-ChenRSC medicinal chemistry
22023Performance assessment of the Bruker Biotyper MALDI-TOF MS for the identification of difficult-to-identify viridans group streptococciWan, Tsai-Wen; Lee, Tai-Fen; Chen, Xiang-Jun; Hunag, Yun-Tsung; LEE-JENE TENG ; PO-REN HSUEH ; HAO-CHIEH CHIU Journal of clinical microbiology
32023Repurposing the tyrosine kinase inhibitor nilotinib for use against intracellular multidrug-resistant Salmonella TyphimuriumChou, Shih-Hsiu; Wan, Tsai-Wen; Shiau, Chung-Wai; Chen, Ling-Han; Lin, Hsueh-Chun; HAO-CHIEH CHIU Journal of microbiology, immunology, and infection00
42022Rapid Bactericidal Activity of SC5005 Combined with Docosahexaenoic Acid against Multidrug-Resistant Staphylococcus aureus Persisters and BiofilmsYeo, Hui-Hui; Shiau, Chung-Wei; Jao, Yu-Hsuan; Wan, Tsai-Wen; HAO-CHIEH CHIU Antimicrobial agents and chemotherapy00
52022Molecular epidemiology of bacteraemic vancomycin-resistant Enterococcus faecium isolates and in vitro activities of SC5005 and other comparators against these isolates collected from a medical centre in northern Taiwan, 2019-2020Wan, Tsai-Wen; Yeo, Hui-Hui; Lee, Tai-Fen; YU-TSUNG HUANG ; PO-REN HSUEH ; HAO-CHIEH CHIU The Journal of antimicrobial chemotherapy22
62022Discovery of antipsychotic loxapine derivatives against intracellular multidrug-resistant bacteriaLin, Hsueh-Chun; Wu, Yi-Lun; Hsu, Cheng-Yun; Lin, Man-Yi; Chen, Ling-Han; Shiau, Chung-Wai; HAO-CHIEH CHIU RSC Medicinal Chemistry2
72021Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretomeWu, Zhao-Yi; Campeau, Anaamika; Liu, Chao-Hsien; Gonzalez, David J; Yamaguchi, Masaya; Kawabata, Shigetada; Lu, Chieh-Hsien; Lai, Chian-Yu; HAO-CHIEH CHIU ; YUNG-CHI CHANG Virulence43
82021SC5005 dissipates the membrane potential to kill Staphylococcus aureus persisters without detectable resistanceLu, Chieh-Hsien; Shiau, Chung-Wai; YUNG-CHI CHANG ; HSIU-NI KUNG ; JUI-CHING WU ; Lim, Chui-Hian; Yeo, Hui-Hui; Chang, Han-Chu; Chien, Han-Sheng; Huang, Sheng-Hsuan; Hung, Wei-Kang; Wei, Jun-Rong; HAO-CHIEH CHIU The Journal of antimicrobial chemotherapy88
92021Potentially conjugative plasmids harboring Tn6636, a multidrug-resistant and composite mobile element, in Staphylococcus aureusWan, Tsai-Wen; Liu, Yu-Jung; YUN-TUNG WANG ; Lin, Yu-Tzu; Hsu, Jia-Chuan; JUI-CHANG TSAI ; HAO-CHIEH CHIU ; PO-REN HSUEH ; Hung, Wei-Chun; LEE-JENE TENG Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi55
102021A Novel Dibenzoxazepine Attenuates Intracellular Salmonella Typhimurium Oxidative Stress ResistanceHsu, Cheng-Yun; Wu, Yi-Lun; Lin, Hsueh-Chun; Lin, Man-Yi; Chou, Shih-Hsiu; Shiau, Chung-Wai; HAO-CHIEH CHIU Microbiology spectrum22
112020A celecoxib derivative eradicates antibiotic-resistant staphylococcus aureus and biofilms by targeting yidc2 translocaseSHIOU-RU TZENG ; Huang Y.-W.; Zhang Y.-Q.; Yang C.-Y.; Chien H.-S.; Chen Y.-R.; SUNG-LIANG YU ; Chen C.S.; HAO-CHIEH CHIU International Journal of Molecular Sciences55
122019Loxapine, an antipsychotic drug, suppresses intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophagesYang C.-Y.; Hsu C.-Y.; Fang C.-S.; Shiau C.-W.; Chen C.S.; HAO-CHIEH CHIU Journal of Microbiology, Immunology and Infection1110
132018A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coliKuo, C.-J.; Wang, S.-T.; Lin, C.-M.; HAO-CHIEH CHIU ; Huang, C.-R.; Lee, D.-Y.; Chang, G.-D.; Chou, T.-C.; Chen, J.-W.; GEEN-DONG CHANG Cell Death and Disease1917
142018Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureusSu, J.-C.; Huang, Y.-T.; Chen, C.-S.; HAO-CHIEH CHIU ; Shiau, C.-W.Molecules89
152017Rapid Sputum Multiplex Detection of the M. tuberculosis Complex (MTBC) and Resistance Mutations for Eight Antibiotics by Nucleotide MALDI-TOF MSKANG-YI SU ; BO-SHIUN YAN ; HAO-CHIEH CHIU ; CHONG-JEN YU ; Chang S.-Y.; Jou R.; Liu J.-L.; PO-REN HSUEH ; SUNG-LIANG YU Scientific Reports1610
162017Effects of toluidine blue O (TBO)-photodynamic inactivation on community-associated methicillin-resistant Staphylococcus aureus isolatesTseng S.-P.; Hung W.-C.; Chen H.-J.; Lin Y.-T.; Jiang H.-S.; HAO-CHIEH CHIU ; PO-REN HSUEH ; LEE-JENE TENG ; JUI-CHANG TSAI Journal of Microbiology, Immunology and Infection2521
172016Substituted malonamides and their use as antibacterial drugsHAO-CHIEH CHIU ; Chung-Wai ShiauUS patent: US10800732
182016Substituted malonamides and their use as antibacterial drugsHAO-CHIEH CHIU ; Chung-Wai ShiauEU patent: EP3331852
192016Mutation of the enterohemorrhagic escherichia coli core LPS biosynthesis enzyme RfaD confers hypersusceptibility to host intestinal innate immunity in vivoKuo C.-J.; Chen J.-W.; HAO-CHIEH CHIU ; Teng C.-H.; Hsu T.-I.; Lu P.-J.; Syu W.-J.; Wang S.T.; Chou T.-C.; Chen C.-S.Frontiers in Cellular and Infection Microbiology1518
202016Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasisSu J.-C.; Mar A.-C.; Wu S.-H.; Tai W.-T.; Chu P.-Y.; Wu C.-Y.; Tseng L.-M.; Lee T.-C.; Chen K.-F.; Liu C.-Y.; HAO-CHIEH CHIU ; Shiau C.-W.Scientific Reports4434
212016In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSAChang H.-C.; YU-TSUNG HUANG ; Chen C.-S.; Chen Y.-W.; Su J.-C.; LEE-JENE TENG ; Shiau C.-W.; HAO-CHIEH CHIU Journal of Antimicrobial Chemotherapy2422
222016Substituted malonamides and their use as antibacterial drugsHAO-CHIEH CHIU ; Chung-Wai Shiau中國專利: CN108026027
232016經取代的丙二醯胺化合物及其作爲抗菌藥物的用途HAO-CHIEH CHIU ; Chung-Wai Shiau中華民國專利: I675817
242015A novel fusidic acid resistance determinant, fusF, in Staphylococcus cohniiChen H.-J.; Hung W.-C.; Lin Y.-T.; JUI-CHANG TSAI ; HAO-CHIEH CHIU ; PO-REN HSUEH ; LEE-JENE TENG Journal of Antimicrobial Chemotherapy2020
252014Sensitization of intracellular Salmonella enterica serovar Typhimurium to aminoglycosides in vitro and in vivo by a host-targeted antimicrobial agentLo, Jung-Hsin; Kulp, Samuel K; Chen, Ching-Shih; HAO-CHIEH CHIU Antimicrobial agents and chemotherapy2221
262014Compositions and methods for sensitizing intracellular bacteria to aminoglycosidesHAO-CHIEH CHIU ; Samuel K. Kulp; Ching-Shih ChenUS provisional patent: 61/993819
272013Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanismYang, Y.-L.; Huang, P.-H.; HAO-CHIEH CHIU ; Kulp, S.K.; Chen, C.-S.; Kuo, C.-J.; Chen, H.-D.; Chen, C.-S.Biochemical and Biophysical Research Communications1816
282013Vitamin e facilitates the inactivation of the kinase akt by the phosphatase PHLPP1Huang, P.-H.; Chuang, H.-C.; Chou, C.-C.; Wang, H.; Lee, S.-L.; Yang, H.-C.; HAO-CHIEH CHIU ; Kapuriya, N.; Wang, D.; Kulp, S.K.; Chen, C.-S.Science Signaling4543
292013Enterohaemorrhagic Escherichia coli O157: H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway in Caenorhabditis elegansChou, T.-C.; HAO-CHIEH CHIU ; Kuo, C.-J.; Wu, C.-M.; Syu, W.-J.; Chiu, W.-T.; Chen, C.-S.Cellular Microbiology4848
302012Escherichia coli O104:H4Hsiao-Jan Chen; HAO-CHIEH CHIU ; Lee-Jene TengFormosa Journal of Medicine0
312012Tularemia, A Potential Bioterrorism ThreatHAO-CHIEH CHIU ; Bo-Shiun YanFormosa Journal of Medicine0
322012Anti-Francisella agentsHAO-CHIEH CHIU ; Ching-Shih Chen; Samuel Kulp; John S. Gunn; Larry S. SchlesingerUS patent: US8580827
332012Development of novel antibacterial agents against methicillin-resistant Staphylococcus aureusHAO-CHIEH CHIU ; Lee S.-L.; Kapuriya N.; Wang D.; Chen Y.-R.; SUNG-LIANG YU ; Kulp S.K.; LEE-JENE TENG ; Chen C.-S.Bioorganic and Medicinal Chemistry3529
342010Pyrazole derivatives as anti-Francisella agentsHAO-CHIEH CHIU ; Ching-Shih Chen; Samuel Kulp; John S. Gunn; Larry S. SchlesingerEU patent: EP2246332
352009Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agentHAO-CHIEH CHIU ; Soni, S.; Kulp, S.K.; Curry, H.; Wang, D.; Gunn, J.S.; Schlesinger, L.S.; Chen, C.S.Journal of biomedical science5758
362009Eradication of intracellular Salmonella enterica serovar typhimurium with a small-molecule, host cell-directed agentHAO-CHIEH CHIU ; Kulp, S.K.; Soni, S.; Wang, D.; Gunn, J.S.; Schlesinger, L.S.; Chen, C.-S.Antimicrobial Agents and Chemotherapy6668
372009Pharmacological exploitation of an off-target antibacterial effect of the cyclooxygenase-2 inhibitor celecoxib against Francisella tularensisHAO-CHIEH CHIU ; Yang, J.; Soni, S.; Kulp, S.K.; Gunn, J.S.; Schlesinger, L.S.; Chen, C.-S.Antimicrobial Agents and Chemotherapy1919
382008Anti-infective agents against intracellular pathogensHAO-CHIEH CHIU ; Ching-Shih Chen; Dasheng Wang; John S. Gunn; Larry S. SchlesingerUS patent: US8039502
392006Comparison of Tir from enterohemorrahgic and enteropathogenic Escherichia coli strains: Two homologues with distinct intracellular propertiesChuang C.-H.; HAO-CHIEH CHIU ; Hsu S.-C.; Ho J.-Y.; Syu W.-J.Journal of Biomedical Science44
402006Development of small-molecule cyclin D1-ablative agentsHuang J.-W.; Shiau C.-W.; Yang J.; Wang D.-S.; HAO-CHIEH CHIU ; Chen C.-Y.; Chen C.-S.Journal of Medicinal Chemistry5248
412005Functional analysis of EspB from enterohaemorrhagic Escherichia coliHAO-CHIEH CHIU ; Syu W.-J.Microbiology1415
422003Type III secretion of EspB in enterohemorrhagic Escherichia coli O157:H7HAO-CHIEH CHIU ; Lin W.-S.; Syu W.-J.Archives of Microbiology1717