研究成果


第 1 到 62 筆結果，共 62 筆。

公開日期標題作者來源出版物scopusWOS全文
12024Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase InhibitionJuang, Yu Pu; Tsai, Ju Ying; Gu, Wan Lan; Hsu, Hui Ching; Lin, Chao Lung; Wu, Chin Chung; PI-HUI LIANG Journal of Medicinal Chemistry
22024Effect of Sulfotyrosine and Negatively Charged Amino Acid of Leech-Derived Peptides on Binding and Inhibitory Activity Against ThrombinChen, Tzu-Yin; Shyur, Eileen; Ma, Tzu-Hsuan; Wijeyewickrema, Lakshmi; Lin, Sheng-Wei; Kao, Mu-Rong; PI-HUI LIANG ; Shie, Jiun-Jie; Chuang, Er-Yuan; Liou, Jing-Ping; Hsieh, Yves S YChembiochem : a European journal of chemical biology
32023Design, structure-activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin-based sulfamates as steroid sulfatase inhibitorsChiu, Pei-Fang; Lin, I-Chun; Lu, Yeh-Lin; Chang, Chiao-Nien; Chan, Hui-Yu; Lin, Tzung-Shen; Tsai, Keng-Chang; Hsieh, Yves S Y; MEI-JOU CHEN ; Lin, Mei-Hsiang; PI-HUI LIANG Bioorganic chemistry0
42023PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vγ4+ γδT17 Cells in Imiquimod-Induced Skin InflammationYeh, Chen-Yun; Su, Sheng-Han; Tan, Yeh Fong; Tsai, Tsen-Fang; PI-HUI LIANG ; Kelel, Musin; Weng, Hao-Jui; Hsiao, Yu-Ping; Lu, Chun-Hao; Tsai, Ching-Hui; Lee, Chih-Hung; Clausen, Björn E; Liu, Fu-Tong; YUNG-LING LEE The Journal of investigative dermatology3
52023Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal CancerChiu, Pei Fang; Chang, Chun Kai; Huang, Pin Shuo; Lin, You Yu; Lin, Chung Shun; Yang, Hui Yi; LIH-CHING HSU ; LINDA CHIA-HUI YU ; PI-HUI LIANG Journal of Medicinal Chemistry00
62023Toward an Improved Triterpene 3-O-Glucuronidation: The Systematic Determination of the Relative Reactivities of Glucuronyl Donors and AcceptorsLai, Yen-Hsun; Chou, Yu-Ting; Lin, You-Yu; Wang, Yi-Chi; Cao, Jing-Xiu; PI-HUI LIANG The Journal of organic chemistry
72023Isolation of Anti-SARS-CoV-2 Natural Products Extracted from Mentha canadensis and the Semi-synthesis of Antiviral DerivativesChou, Osbert; Juang, Yu-Pu; TAI-LING CHAO ; Tsai, Sheng-Fa; Chiu, Pei-Fang; Chiou, Chun-Tang; Tsai, Keng-Chang; SUI-YUAN CHANG ; PI-HUI LIANG ; Wong, Chi-HueyJournal of natural products30
82023Subunit vaccines with a saponin-based adjuvant boost humoral and cellular immunity to MERS coronavirusChang, Chi-Chieh; Algaissi, Abdullah; Lai, Chia-Chun; Chang, Chun-Kai; JR-SHIUAN LIN ; Wang, Yi-Shiang; Chang, Bo-Hau; Chang, Yu-Chiuan; Chen, Wei-Ting; Fan, Yong-Qing; Peng, Bi-Hung; Chao, Chih-Yu; SHIOU-RU TZENG ; PI-HUI LIANG ; Sung, Wang-Chou; Hu, Alan Yung-Chih; Chang, Shin C; MING-FU CHANG Vaccine1
92023Structures of the xyloglucans in the monocotyledon family Araceae (aroids)Hsiung, Shih-Yi; Li, Jing; Imre, Balazs; Kao, Mu-Rong; Liao, Hsien-Chun; Wang, Damao; Chen, Chih-Hui; PI-HUI LIANG ; Harris, Philip J; Hsieh, Yves S YPlanta1
102022The Design, Structure-Activity, and kinetic studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl sulfamates as Steroid sulfatase inhibitorsChang, Chiao-Nien; Lin, I-Chun; Lin, Tzung-Sheng; Chiu, Pei-Fang; Lu, Yeh-Lin; Narwane, Manmath; Liu, I-Chen; Hng, Yue; Tsai, Keng-Chang; Lin, Mei-Hsiang; S Y Hsieh, Yves; MEI-JOU CHEN ; PI-HUI LIANG Bioorganic chemistry21
112022Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) DruceLi, Jing; Hsiung, Shih-Yi; Kao, Mu-Rong; Xing, Xiaohui; Chang, Shu-Chieh; Wang, Damao; Hsieh, Pei-Yun; PI-HUI LIANG ; Zhu, Zaibiao; Cheng, Ting-Jen Rachel; Shie, Jiun-Jie; Liou, Jing-Ping; Abbott, D Wade; Kwon, Sung Won; Hsieh, Yves S YCarbohydrate research3
122022Novel Two-Step Process in Cellulose Depolymerization: Hematite-Mediated Photocatalysis by Lytic Polysaccharide Monooxygenase and Fenton ReactionWang, Damao; Kao, Mu-Rong; Li, Jing; Sun, Peicheng; Meng, Qijun; Vyas, Anisha; PI-HUI LIANG ; Wang, Yane-Shih; Hsieh, Yves S YJournal of agricultural and food chemistry4
132022Design and Synthesis of 1-O- and 6'-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 InhibitorsTseng, Kuei-Yao; Tzeng, Zheng-Hao; Cheng, Ting-Jen Rachel; PI-HUI LIANG ; Hung, Shang-ChengFrontiers in chemistry
142022Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2Juang, Yu-Pu; Chou, Yu-Ting; Lin, Ru-Xian; Ma, Hsiu-Hua; TAI-LING CHAO ; Jan, Jia-Tsrong; SUI-YUAN CHANG ; PI-HUI LIANG European journal of medicinal chemistry9
152021Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitorsKao, Ting-Yu; Wu, Hwa-Wei; SHOEI-SHENG LEE ; PI-HUI LIANG ; JIH-HWA GUH ; LIH-CHING HSU Journal of food and drug analysis32
162021Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-FluorouracilChang, Chun-Kai; Chiu, Pei-Fang; Yang, Hui-Yi; Juang, Yu-Pu; Lai, Yen-Hsun; Lin, Tzung-Sheng; LIH-CHING HSU ; LINDA CHIA-HUI YU ; PI-HUI LIANG Journal of Medicinal Chemistry16
172021Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infectionJan, Jia Tsrong; Cheng, Ting Jen Rachel; Juang, Yu Pu; Ma, Hsiu Hua; Wu, Ying Ta; Yang, Wen Bin; Cheng, Cheng Wei; Chen, Xiaorui; Chou, Ting Hung; Shie, Jiun Jie; Cheng, Wei Chieh; Chein, Rong Jie; Mao, Shi Shan; PI-HUI LIANG ; Ma, Che; Hung, Shang Cheng; Wong, Chi HueyProceedings of the National Academy of Sciences of the United States of America122111
182021Structures, Biosynthesis, and Physiological Functions of (1,3;1,4)-β-d-GlucansShu-Chieh Chang; Rebecka Karmakar Saldivar; PI-HUI LIANG ; Yves S. Y. HsiehCells1111
192021Production of Structurally Defined Chito-Oligosaccharides with a Single N-Acetylation at Their Reducing End Using a Newly Discovered Chitinase from Paenibacillus pabuliJing Li; Damao Wang; Shu-Chieh Chang; PI-HUI LIANG ; Vaibhav Srivastava; Shih-Yun Guu; Jiun-Jie Shie; Kay-Hooi Khoo; Vincent Bulone; Yves S. Y. HsiehJournal of Agricultural and Food Chemistry53
202021FUT8 Remodeling of EGFR Regulates Epidermal Keratinocyte Proliferation during Psoriasis DevelopmentMusin Kelel; Ruey-Bing Yang; TSEN-FANG TSAI ; PI-HUI LIANG ; Wu F.-Y.; Yu-Tien Huang; Ming-Fong Yang; Yu-Ping Hsiao; LI-FANG WANG ; Chen-Fen Tu; Fu-Tong Liu; Yungling L. LeeJournal of Investigative Dermatology74
212020Further Insights on Structural Modifications of Muramyl Dipeptides to Study the Human NOD2 Stimulating ActivityCheng, Wei-Chieh; You, Ting-Yun; Teo, Zhen-Zhuo; Sayyad, Ashik A; Maharana, Jitendra; Guo, Chih-Wei; PI-HUI LIANG ; Lin, Chung-Shun; Meng, Fan-ChunChemistry, an Asian journal1110
222020Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponinsJuang Y.-P.; Lin Y.-Y.; Chan S.-H.; Chang C.-K.; Shie J.-J.; Hsieh Y.S.Y.; JIH-HWA GUH ; PI-HUI LIANG Bioorganic Chemistry98
232020Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfateTzung-Sheng Lin; Chang-Hsun Hsieh; Chin Kuo; Juang Y.-P.; Yves S.Y. Hsieh; HONGSEN CHIANG ; Shang-Cheng Hung; CHING-CHUAN JIANG ; PI-HUI LIANG Carbohydrate Polymers1716
242020Design and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitorsHng, Yue; Lin, Mei-Hsiang; Lin, Tzung-Sheng; Liu, I-Chen; Lin, I-Chun; Lu, Yeh-Lin; Chang, Chiao-Nien; Chiu, Pei-Fang; Tsai, Keng-Chang; MEI-JOU CHEN ; PI-HUI LIANG Bioorganic chemistry1112
252020Biological and Pharmacological Effects of Synthetic SaponinsYu-Pu Juang; PI-HUI LIANG Molecules5343
262019Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marcLiang, Pi-Hui; Wang, Damao; Xing, Xiaohui; Cheng, Ting-Jen Rachel; PI-HUI LIANG ; Bulone, Vincent; Park, Jeong Hill; Hsieh, Yves S YInternational journal of biological macromolecules2424
272019Glucose Metabolites Exert Opposing Roles in Tumor ChemoresistanceHuang, Chung-Yen; Huang, Ching-Ying; Pai, Yu-Chen; BEEN-REN LIN ; TSUNG-CHUN LEE ; PI-HUI LIANG ; LINDA CHIA-HUI YU Frontiers in Oncology1413
282018Traversal of the Blood-Brain Barrier by Cleavable l-Lysine Conjugates of ApigeninWong, Tsung-Yun; Tsai, Ming-Shian; Hsu, Lih-Ching; Lin, Shu-Wha; PI-HUI LIANG Journal of agricultural and food chemistry6
292018An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemiaChan S.-H.; PI-HUI LIANG ; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology1111
3020182- O- N-Benzylcarbamoyl as a Protecting Group To Promote β-Selective Glycosylation and Its Applications in the Stereoselective Synthesis of OligosaccharidesLu, Yin-Jen; Lai, Yen-Hsun; Lin, You-Yu; Wang, Yi-Chi; PI-HUI LIANG The Journal of organic chemistry45
312018Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamineLin, You-Yu; Chan, She-Hung; Juang, Yu-Pu; Hsiao, Hsin-Min; JIH-HWA GUH ; PI-HUI LIANG European Journal of Medicinal Chemistry1716
322018A highly HDAC6-selective inhibitor acts as a fluorescent probeHo, Yi-Hsun; Wang, Kuang-Jui; Hung, Pei-Yun; Cheng, Yi-Sheng ; Liu, Jia-Rong; Fung, Sheang-Tze; PI-HUI LIANG ; JI-WANG CHERN ; CHAO-WU YU Organic and Biomolecular Chemistry19
332018Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assaysCheng H.-W.; Wang H.-W.; Wong T.-Y.; Yeh H.-W.; Chen Y.-C.; Liu D.-Z.; PI-HUI LIANG Bioorganic & Medicinal Chemistry00
342016Structural Insights into the Allosteric Operation of the Lon AAA+ ProteaseLin, Chien-Chu; Su, Shih-Chieh; Su, Ming-Yuan; PI-HUI LIANG ; Feng, Chia-Cheng; Wu, Shih-Hsiung; Chang, Chung-IStructure (London, England : 1993)29
352016Rearrangement reactions in the fluorination of D-glucopyranoside at the C-4 position by DASTLin T.-S.; Tsai W.-T.; PI-HUI LIANG Tetrahedron67
362015Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation ActivityChen, Kuo-Ting; Huang, Duen-Yi; Chiu, Cheng-Hsin; WAN-WAN LIN ; PI-HUI LIANG ; Cheng, Wei-ChiehChemistry - A European Journal18
372015Galactosylated liposome as a dendritic cell-targeted mucosal vaccine for inducing protective anti-tumor immunityJiang, Ping-Lun; Lin, Hung-Jun; Wang, Hsiao-Wen; Tsai, Wen-Yu; Lin, Shen-Fu; Chien, Mei-Yin; PI-HUI LIANG ; YI-YOU HUANG ; Liu, Der-ZenActa Biomaterialia49
382015S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitorsYeh, Hsien-Wei; Lin, Tzung-Sheng; Wang, Hsiao-Wen; Cheng, Hou-Wen; Liu, Der-Zen; PI-HUI LIANG Organic and Biomolecular Chemistry
392014Synthesis and anti-cancer activity of a glycosyl library of \varvec{N} N -acetylglucosamine-bearing oleanolic acidZeng, Yi-Bing; Hsiao, Hsin-Min; Chan, She-Hung; Wang, Ying-Hsin; Lin, You-Yu; Kuo, Yu-Hsuan; JIH-HWA GUH ; PI-HUI LIANG Molecular Diversity14
402013GSTP1 is a hub gene for gene-air pollution interactions on childhood asthmaSu, M.W.; Tsai, C.H.; Tung, K.Y.; Hwang, B.F.; PI-HUI LIANG ; BOR-LUEN CHIANG ; YAO-HSU YANG ; YUNG-LING LEE Allergy: European Journal of Allergy and Clinical Immunology26
412013Synthesis and biological evaluation of novel C-aryl D-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitorsLin, Tzung-Sheng; Liw, Ya-Wen; Song, Jen-Shin; Hsieh, Tsung-Chih; Yeh, Hsien-Wei; LIH-CHING HSU ; CHUN-JUNG LIN ; Wu, Szu-Huei; PI-HUI LIANG Bioorganic and Medicinal Chemistry1311
422013Development of a novel non-radioactive cell-based method for the screening of SGLT1 and SGLT2 inhibitors using 1-NBDGChang, Hung-Chi; Yang, Su-Fu; Huang, Ching-Chun; Lin, Tzung-Sheng; PI-HUI LIANG ; CHUN-JUNG LIN ; LIH-CHING HSU Molecular BioSystems1716
432013CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in LiverYang, Chih Ya; Chen, Jiun Bo; Tsai, Ting Fen; Tsai, Yi Chen; Tsai, Ching Yen; PI-HUI LIANG ; Hsu, Tsui Ling; Wu, Chung Yi; Netea, Mihai G.; Wong, Chi Huey; Hsieh, Shie LiangPLoS ONE71
442013Rapid preparation of mycobacterium N-glycolyl lipid i and lipid II derivatives: A biocatalytic approachChen K.-T. ; Kuan Y.-C.; Fu W.-C.; PI-HUI LIANG ; Cheng T.-J. R.; Wong C.-H.; Cheng W.-C.Chemistry - A European Journal1616
452013Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategyWang Y.-H.; Yeh H.-W.; Wang H.-W.; Yu C.-C.; JIH-HWA GUH ; Liu D.-Z.; PI-HUI LIANG Carbohydrate Research1313
462013Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunizationWang H.-W; Jiang P.-L; Lin S.-F; Lin H.-J; Ou K.-L; Deng W.-P; Lee L.-W; YI-YOU HUANG ; PI-HUI LIANG ; Liu D.-Z.Acta Biomaterialia3634
472012Synthesis and evaluation of acyl-chain- and galactose-6''-modified analogues of α-GalCer for NKT cell activationHsieh, Ming-Han; Hung, Jung-Tung; Liw, Ya-Wen; Lu, Yin-Jen; Wong, Chi-Huey; Yu, Alice L; PI-HUI LIANG Chembiochem : a European journal of chemical biology20
482012Gene-gene and gene-environmental interactions of childhood asthma: A multifactor dimension reduction approachYUNG-LING LEE ; Su, Ming-Wei; Tung, Kuan-Yen; PI-HUI LIANG ; Liang, Pi-Hui ; Tsai, Ching-Hui; Kuo, Nai-Wei; Lee, Yungling Leo; Christensen, Brock C.PLoS ONE4847
492011Total synthesis of polyprenyl N-Glycolyl Lipid II as a mycobacterial transglycosylase substrateMeng F.-C. ; Chen K.-T.; Huang L.-Y.; Shih H.-W.; Chang H.-H.; Nien F.-Y.; PI-HUI LIANG ; Cheng T.-J. R.; Wong C.-H.; Cheng W.-C.Organic Letters2119
502010A green and regioselective acetylation of thioglycoside with ethyl acetatePI-HUI LIANG ; Lu, Yin Jen; Tang, Ting HsuanTetrahedron Letters
512009New development of glycan arraysWu, Chung-Yi; PI-HUI LIANG ; Wong, Chi-HueyOrganic & biomolecular chemistry60
522009A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDPTsou, En Lun; Yeh, Yao Ting; PI-HUI LIANG ; Cheng, Wei ChiehTetrahedron
532008Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine productionPI-HUI LIANG ; Imamura, Masakazu; Li, Xiangming; Wu, Douglass; Fujio, Masakazu; Guy, Richard T; Wu, Bing-Ching; Tsuji, Moriya; Wong, Chi-HueyJournal of the American Chemical Society50
542008Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGNWang, Sheng-Kai; PI-HUI LIANG ; Astronomo, Rena D.; Hsu, Tsui-Ling; Hsieh, Shie-Liang; Burton, Dennis R.; Wong, Chi-HueyProceedings of the National Academy of Sciences of the United States of America
552008Glycan arrays: biological and medical applicationsPI-HUI LIANG ; Wu, Chung-Yi; Greenberg, William A.; Wong, Chi-HueyCurrent Opinion in Chemical Biology
562007Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: Determination of surface and solution dissociation constantsPI-HUI LIANG ; Wang, Sheng-Kai; Wong, Chi-HueyJournal of the American Chemical Society
572007D-fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitolsSugiyama M.; Hong Z.-Y.; PI-HUI LIANG ; Dean Stephen M.; Whalen Lisa J.; Wong C.-H.Journal of the American Chemical Society126113
582006Large-scale synthesis of per-O-acetylated saccharides and their sequential transformation to glycosyl bromides and thioglycosidesLin, Chan Ching; Huang, Li Cheng; PI-HUI LIANG ; Liu, Ching Yang; Lin, Chun ChengJournal of Carbohydrate Chemistry
592006Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritisPI-HUI LIANG ; Cheng W.-C.; Lee Y.-L.; Yu H.-P.; Wu Y.-T.; Lin Y.-L.; Wong C.-H.ChemBioChem115106
602004Intramolecular Heck cyclization to the galanthamine-type alkaloids: Total synthesis of (±)-lycoraminePI-HUI LIANG ; Liu, Jing Ping; LING-WEI HSIN ; Cheng, Chen YuTetrahedron
612003Synthesis of galanthamine analogs as acetylcholinesterase inhibitors via intramolecular heck cvclizationPI-HUI LIANG ; LING-WEI HSIN ; Pong S.-L.; Hsu C.-H.; Cheng C.-Y.Journal of the Chinese Chemical Society1212
622002N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openersPI-HUI LIANG ; LING-WEI HSIN ; Cheng, Chen-YuBioorganic and Medicinal Chemistry32