| 公開日期 | 標題 | 作者 | 來源出版物 | scopus | WOS | 全文 |
1 | 2024 | Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway | Hsu, Jui-Ling; Leu, Wohn-Jenn; LIH-CHING HSU ; Hsieh, Chia-Hsun; JIH-HWA GUH | Oncology letters | | | |
2 | 2024 | Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism | Du, Chi-Min; Leu, Wohn-Jenn; Jiang, Yi-Huei; Chan, She-Hung; Chen, Ih-Sheng; Chang, Hsun-Shuo; LIH-CHING HSU ; Hsu, Jui-Ling; JIH-HWA GUH | Naunyn-Schmiedeberg's archives of pharmacology | | | |
3 | 2024 | A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer | Ye, Pei-Chen; Leu, Wohn-Jenn; Yeh, Tsung-Yu; Hsu, Yu-Tung; Lin, Yi-Chin; Wei, Zi-Yuan; Chen, Yi-Chin; Chiang, Yi-Chang; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; JI-WANG CHERN ; CHAO-WU YU ; JIH-HWA GUH | The Prostate | | | |
4 | 2024 | Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3–c]quinolin-12(12H)-one as potential breast cancer drugs | Sumitra, Maryam Rachmawati; Chen, Lung Ching; Tsai, Wei Chen; Ansar, Muhamad; Lawal, Bashir; Mokgautsi, Ntlotlang; JIH-HWA GUH ; Wu, Alexander T.H.; Huang, Hsu Shan | Arabian Journal of Chemistry | | | |
5 | 2023 | Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancer | Chiang, Yi-Chang; Leu, Wohn-Jenn; Chen, Yi-Chin; Ye, Pei-Chen; Hsu, Yu-Tung; Hsiao, Yu-Chi; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; Huang, Hsu-Shan; JIH-HWA GUH | The Prostate | | | |
6 | 2023 | Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells | Hsu, Ya-Fen; FAN-LU KUNG ; Huang, Tzu-En; Deng, Yi-Ning; JIH-HWA GUH ; Marchetti, Paolo; Marchesi, Elena; Perrone, Daniela; Navacchia, Maria Luisa; LIH-CHING HSU | Molecules (Basel, Switzerland) | 3 | 3 | |
7 | 2022 | Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays | Hung, Hsueh-Chih; Li, Li-Cheng; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU | Molecules (Basel, Switzerland) | 3 | 1 | |
8 | 2022 | The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling Pathways | Weng, Hao-Cheng; Sung, Chieh-Ju; Hsu, Jui-Ling; Leu, Wohn-Jenn; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU | Frontiers in pharmacology | 9 | 6 | |
9 | 2021 | Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect | Leu, Wohn-Jenn; Chang, Hsun-Shuo; Chen, Ih-Sheng; JIH-HWA GUH ; Chan, She-Hung | International journal of molecular sciences | 5 | 5 | |
10 | 2021 | Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer | Hsu, Jui-Ling; Leu, Wohn-Jenn; Zhong, Nan-Shan; JIH-HWA GUH | Molecules (Basel, Switzerland) | 5 | 3 | |
11 | 2021 | Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitors | Kao, Ting-Yu; Wu, Hwa-Wei; SHOEI-SHENG LEE ; PI-HUI LIANG ; JIH-HWA GUH ; LIH-CHING HSU | Journal of food and drug analysis | 3 | 2 | |
12 | 2020 | Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism Studies | Leu W.-J.; Chu J.-C.; Hsu J.-L.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Huang W.-J.; JIH-HWA GUH | Molecules (Basel, Switzerland) | 8 | 8 | |
13 | 2020 | Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins | Juang Y.-P.; Lin Y.-Y.; Chan S.-H.; Chang C.-K.; Shie J.-J.; Hsieh Y.S.Y.; JIH-HWA GUH ; PI-HUI LIANG | Bioorganic Chemistry | 9 | 8 | |
14 | 2020 | Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma Cells | Huang T.-E.; Deng Y.-N.; Hsu J.-L.; Leu W.-J.; Marchesi E.; Capobianco M.L.; Marchetti P.; Navacchia M.L.; JIH-HWA GUH ; Perrone D.; LIH-CHING HSU | Frontiers in Pharmacology | 19 | 18 | |
15 | 2020 | Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling | Hsu J.-L.; Leu W.-J.; LIH-CHING HSU ; Ho C.-H.; SHIH-PING LIU ; JIH-HWA GUH | Frontiers in Oncology | 11 | 9 | |
16 | 2020 | Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancers | Chang Y.-C.; Tseng Y.-L.; Leu W.-J.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH | International Journal of Molecular Sciences | 1 | 1 | |
17 | 2020 | Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer | Wang Y.; Zhang L.; Wei Y.; Huang W.; Li L.; Wu A.-A.; Dastur A.; Greninger P.; Bray W.M.; Zhang C.-S.; Li M.; Lian W.; Hu Z.; Wang X.; Liu G.; Yao L.; JIH-HWA GUH ; Chen L.; Wang H.-R.; Zhou D.; Lin S.-C.; Xu Q.; Shen Y.; Zhang J.; Jurica M.S.; Benes C.H.; Deng X. | Cell Chemical Biology | 15 | 13 | |
18 | 2020 | Ascleposide, a natural cardenolide, induces anticancer signaling in human castration-resistant prostatic cancer through Na+/K+-ATPase internalization and tubulin acetylation | Leu W.-J.; Wang C.-T.; Hsu J.-L.; Chen I.-S.; Chang H.-S.; JIH-HWA GUH | Prostate | 9 | 8 | |
19 | 2020 | The (+)-brevipolide H displays anticancer activity against human castration-resistant prostate cancer: The role of oxidative stress and Akt/mTOR/p70S6K dependent pathways in G1 checkpoint arrest and apoptosis | Sheng Y.-H.; Leu W.-J.; Chen C.-N.; Hsu J.-L.; Liu Y.-T.; LIH-CHING HSU ; Hou D.-R.; JIH-HWA GUH | Molecules | 4 | 4 | |
20 | 2020 | Mechanistic study of triazole based aminodiol derivatives in leukemic cells—crosstalk between mitochondrial stress-involved apoptosis and autophagy | Chan S.-H.; Leu W.-J.; Swain S.P.; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH | International Journal of Molecular Sciences | 1 | 2 | |
21 | 2019 | Phosphodiesterase type 5 (PDE5) inhibitors sensitize topoisomerase II inhibitors in killing prostate cancer through PDE5-independent impairment of HR and NHEJ DNA repair systems | Chang J.-F.; Hsu J.-L.; Sheng Y.-H.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Chan M.-L.; LIH-CHING HSU ; SHIH-PING LIU ; JIH-HWA GUH | Frontiers in Oncology | 11 | 13 | |
22 | 2019 | Extract from plectranthus amboinicus inhibit maturation and release of interleukin 1β through inhibition of NF-κB nuclear translocation and NLRP3 inflammasome activation | Leu W.-J.; Chen J.-C.; JIH-HWA GUH | Frontiers in Pharmacology | 28 | 29 | |
23 | 2019 | Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents | Chen T.-C.; JIH-HWA GUH ; Hsu H.-W.; Chen C.-L.; Lee C.-C.; Wu C.-L.; Lee Y.-R.; JING-JER LIN ; Yu D.-S.; Huang H.-S. | Arabian Journal of Chemistry | 8 | 7 | |
24 | 2019 | Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents | Chen T.-C.; Yu D.-S.; Chen S.-J.; Chen C.-L.; Lee C.-C.; Hsieh Y.-Y.; Chang L.-C.; JIH-HWA GUH ; JING-JER LIN ; Huang H.-S. | Arabian Journal of Chemistry | 11 | 11 | |
25 | 2019 | The combination of MK-2206 and WZB117 exerts a synergistic cytotoxic effect against breast cancer cells | Li Y.-L.; Weng H.-C.; Hsu J.-L.; SHU-WHA LIN ; JIH-HWA GUH ; LIH-CHING HSU | Frontiers in Pharmacology | 24 | 22 | |
26 | 2019 | Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer Activity | Marchesi E.; Chinaglia N.; Capobianco M.L.; Marchetti P.; Huang T.-E.; Weng H.-C.; JIH-HWA GUH ; LIH-CHING HSU ; Perrone D.; Navacchia M.L. | ChemMedChem | 17 | 17 | |
27 | 2018 | Retraction of "Development of Novel Adenosine Monophosphate-Activated Protein Kinase Activators" | JIH-HWA GUH ; Chang, Wei-Ling; Yang, Jian; Lee, Su-Lin; Wei, Shuo; Wang, Dasheng; Kulp, Samuel K; Chen, Ching-Shih | Journal of medicinal chemistry | | | |
28 | 2018 | An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia | Chan S.-H.; PI-HUI LIANG ; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 11 | 11 | |
29 | 2018 | Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamine | Lin, You-Yu; Chan, She-Hung; Juang, Yu-Pu; Hsiao, Hsin-Min; JIH-HWA GUH ; PI-HUI LIANG | European Journal of Medicinal Chemistry | 17 | 16 | |
30 | 2018 | Synthesis, characterization and cancer cell growth inhibition activity of ruthenium(II) complexes bearing bidentate pyrrole-imine ligands | Chen G.-H.; Leu W.-J.; JIH-HWA GUH ; Lin C.-H.; Huang J.-H. | Journal of Organometallic Chemistry | 7 | 5 | |
31 | 2018 | Ruthenium (II) complexes containing dehydroacetic acid and its imine derivative ligands. Synthesis, characterization and cancer cell growth anti-proliferation activity (GI50) study | Chen K.-H.; Lin T.-H.; Hsu T.-E.; Li Y.-J.; Chen G.-H.; Leu W.-J.; JIH-HWA GUH ; Lin C.-H.; Huang J.-H. | Journal of Organometallic Chemistry | 8 | 6 | |
32 | 2018 | Para-toluenesulfonamide induces anti-tumor activity through Akt-dependent and -independent mTOR/p70S6K pathway: Roles of lipid raft and cholesterol contents | Hsu J.-L.; Leu W.-J.; LIH-CHING HSU ; SHIH-PING LIU ; Zhong N.-S.; JIH-HWA GUH | Frontiers in Pharmacology | 10 | 19 | |
33 | 2018 | Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities | Chao S.-W.; Chen L.-C.; Yu C.-C.; Liu C.-Y.; Lin T.E.; JIH-HWA GUH ; Wang C.-Y.; Chen C.-Y.; Hsu K.-C.; Huang W.-J. | European Journal of Medicinal Chemistry | 20 | 17 | |
34 | 2017 | Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways | Chan M.-L.; Yu C.-C.; Hsu J.-L.; Leu W.-J.; Chan S.-H.; LIH-CHING HSU ; SHIH-PING LIU ; Ivantcova P.M.; Dogan ?.; Br?se S.; Kudryavtsev K.V.; JIH-HWA GUH | Oncotarget | 8 | 8 | |
35 | 2016 | Synthesis and characterization of ruthenium compounds incorporating keto-amine ligands. The applications of catalytic transfer hydrogenation and cancer cell inhibition | Lin T.-H.; Das K.; Datta A.; Leu W.-J.; Hsiao H.-C.; Lin C.-H.; JIH-HWA GUH ; Huang J.-H. | Journal of Organometallic Chemistry | 8 | 8 | |
36 | 2016 | Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: The role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways | Leu W.-J.; Swain S.P.; Chan S.-H.; Hsu J.-L.; SHIH-PING LIU ; Chan M.-L.; Yu C.-C.; LIH-CHING HSU ; Chou Y.-L.; Chang W.-L.; Hou D.-R.; JIH-HWA GUH | Oncotarget | 14 | 14 | |
37 | 2016 | ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5 | Sun H.-L.; Cui R.; Zhou J.; Teng K.-Y.; Hsiao Y.-H.; Nakanishi K.; Fassan M.; Luo Z.; Shi G.; Tili E.; Kutay H.; Lovat F.; Vicentini C.; Huang H.-L.; Wang S.-W.; Kim T.; Zanesi N.; Jeon Y.-J.; Lee T.J.; JIH-HWA GUH ; Hung M.-C.; Ghoshal K.; Teng C.-M.; Peng Y.; Croce C.M. | Cancer Cell | 114 | 102 | |
38 | 2016 | Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth | Lai W.-T.; Cheng K.-L.; Baruchello R.; Rondanin R.; Marchetti P.; Simoni D.; Lee R.M.; JIH-HWA GUH ; LIH-CHING HSU | Biochemical Pharmacology | 7 | 7 | |
39 | 2015 | Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult | Chan M.-L.; Liang J.-W.; LIH-CHING HSU ; Chang W.-L.; SHOEI-SHENG LEE ; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 39 | 33 | |
40 | 2015 | Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - A crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation | Chang W.-L.; LIH-CHING HSU ; Leu W.-J.; Chen C.-S.; JIH-HWA GUH | Oncotarget | 39 | 35 | |
41 | 2015 | Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c[[1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents | Lee Y.-R.; Chen T.-C.; Lee C.-C.; Chen C.-L.; Ahmed Ali A.A.; Tikhomirov A.; JIH-HWA GUH ; Yu D.-S.; Huang H.-S. | European Journal of Medicinal Chemistry | 25 | 23 | |
42 | 2015 | Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors | Chang Y.-H.; Leu W.-J.; Datta A.; Hsiao H.-C.; Lin C.-H.; JIH-HWA GUH ; Huang J.-H. | Dalton Transactions | 17 | 16 | |
43 | 2015 | Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells - A critical role of Cdk1 in mitotic entry | Chang W.-L.; Yu C.-C.; Chen C.-S.; JIH-HWA GUH | Biochemical Pharmacology | 19 | 19 | |
44 | 2015 | Menthols as Chiral Auxiliaries for Asymmetric Cycloadditive Oligomerization: Syntheses and Studies of β-Proline Hexamers | Kudryavtsev K.V.; Ivantcova P.M.; Muhle-Goll C.; Churakov A.V.; Sokolov M.N.; Dyuba A.V.; Arutyunyan A.M.; Howard J.A.K.; Yu C.-C.; JIH-HWA GUH ; Zefirov N.S.; Br?se S. | Organic Letters | 14 | 15 | |
45 | 2015 | Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma | Hsu J.-L.; Liu F.-L.; LIH-CHING HSU ; Chang H.-S.; Leu W.-J.; Yu C.-C.; Chang W.-L.; Chen I.-S.; FAN-LU KUNG ; JIH-HWA GUH | Oncotarget | 6 | 5 | |
46 | 2015 | Structural studies and anticancer activity of a novel class of β-peptides | Kudryavtsev K.V.; Yu C.-C.; Ivantcova P.M.; Polshakov V.I.; Churakov A.V.; Br?se S.; Zefirov N.S.; JIH-HWA GUH | Chemistry - An Asian Journal | 15 | 14 | |
47 | 2015 | Cytotoxic protobassic acid glycosides from Planchonella obovata leaf | Chen H.-Y.; JIH-HWA GUH ; Chan S.-H.; SHOEI-SHENG LEE | Phytochemistry Letters | 7 | 7 | |
48 | 2015 | Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway | Ho C.-H.; Hsu J.-L.; SHIH-PING LIU ; LIH-CHING HSU ; Chang W.-L.; Chao C.C.-K.; JIH-HWA GUH | Prostate | 14 | 14 | |
49 | 2015 | KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora a activity | Yu C.-C.; SHIH-PING LIU ; Hsu J.-L.; Hsu J.T.A.; Kudryavtsev K.; JIH-HWA GUH | Journal of Biomedical Science | 1 | 1 | |
50 | 2014 | Synthesis and anti-cancer activity of a glycosyl library of \varvec{N} N -acetylglucosamine-bearing oleanolic acid | Zeng, Yi-Bing; Hsiao, Hsin-Min; Chan, She-Hung; Wang, Ying-Hsin; Lin, You-Yu; Kuo, Yu-Hsuan; JIH-HWA GUH ; PI-HUI LIANG | Molecular Diversity | 14 | | |
51 | 2014 | A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides | Mulani S.K.; JIH-HWA GUH ; Mong K.-K.T. | Organic and Biomolecular Chemistry | 36 | 34 | |
52 | 2014 | The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells | Lin Y.-H.; Chen B.Y.-H.; Lai W.-T.; Wu S.-F.; JIH-HWA GUH ; ANN-LII CHENG ; LIH-CHING HSU | Naunyn-Schmiedeberg's Archives of Pharmacology | 34 | 32 | |
53 | 2014 | Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer | Hsu J.-L.; Lee Y.-J.; Leu W.-J.; Dong Y.-S.; Pan S.-L.; Uang B.-J.; JIH-HWA GUH | Journal of Urology | 12 | 11 | |
54 | 2014 | Ring fusion strategy for the synthesis of anthra[2,3-d ]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents | Chen C.-L.; Liu F.-L.; Lee C.-C.; Chen T.-C.; Chang W.-W.; JIH-HWA GUH ; Ahmed Ali A.A.; Chang D.-M.; Huang H.-S. | European Journal of Medicinal Chemistry | 20 | 17 | |
55 | 2014 | Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle | Leu W.-J.; Chang H.-S.; Chan S.-H.; Hsu J.-L.; Yu C.-C.; LIH-CHING HSU ; Chen I.-S.; JIH-HWA GUH | PLoS ONE | 26 | 24 | |
56 | 2014 | A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase i | Yu C.-C.; Pan S.-L.; Chao S.-W.; SHIH-PING LIU ; Hsu J.-L.; Yang Y.-C.; TSAI-KUN LI ; Huang W.-J.; JIH-HWA GUH | Biochemical Pharmacology | 29 | 28 | |
57 | 2014 | Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation | Liu F.-L.; Hsu J.-L.; Lee Y.-J.; Dong Y.-S.; FAN-LU KUNG ; Chen C.-S.; JIH-HWA GUH | European Journal of Pharmacology | 4 | 3 | |
58 | 2014 | Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption | Che-Jen Hsiao; George Hsiao; Wei-Lin Chen; Shih-Wei Wang; Chun-Ping Chiang; Liu L.-Y.; JIH-HWA GUH ; Tzong-Huei Lee ; Chi-Li Chung | Journal of Natural Products | 46 | 43 | |
59 | 2014 | A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway | Hsu J.-L.; SHIH-PING LIU ; Lee C.-C.; LIH-CHING HSU ; Ho Y.-F.; Huang H.-S.; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 13 | 12 | |
60 | 2014 | Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation | Wang W.-T.; Chen Y.-H.; Hsu J.-L.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Ho Y.-F.; LIH-CHING HSU ; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 27 | 25 | |
61 | 2013 | Total synthesis of 14,21-diepi-squamocin-K | Liu C.-W.; Yeh T.-C.; Chen C.-H.; Yu C.-C.; Chen C.-S.; Hou D.-R.; JIH-HWA GUH | Tetrahedron | 6 | 5 | |
62 | 2013 | Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy | Wang Y.-H.; Yeh H.-W.; Wang H.-W.; Yu C.-C.; JIH-HWA GUH ; Liu D.-Z.; PI-HUI LIANG | Carbohydrate Research | 13 | 13 | |
63 | 2013 | Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades | Chan S.-H.; Leu W.-J.; LIH-CHING HSU ; Chang H.-S.; Hwang T.-L.; Chen I.-S.; Chen C.-S.; JIH-HWA GUH | Biochemical Pharmacology | 17 | 15 | |
64 | 2013 | Erratum: Anti-angiogenic effects and mechanism of prazosin (The Prostate (2011) 71 (976-984)) | Liao C.-H.; JIH-HWA GUH ; SHIH-CHIEH CHUEH ; HONG-JENG YU | Prostate | 0 | 0 | |
65 | 2013 | 2-(1H-Imidazol-1-yl)-4-[3-(trifluoromethyl)phenyl]-1,3-thiazole | Kudryavtsev K.V.; Churakov A.V.; JIH-HWA GUH | Acta Crystallographica Section E: Structure Reports Online | 1 | 0 | |
66 | 2013 | A novel hydroxysuberamide derivative potentiates MG132-mediated anticancer activity against human hormone refractory prostate cancers - The role of histone deacetylase and endoplasmic reticulum stress | Chen Y.-C.; Huang W.-J.; Hsu J.-L.; Yu C.-C.; Wang W.-T.; JIH-HWA GUH | Prostate | 6 | 6 | |
67 | 2013 | Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation | Yu C.-C.; Wu P.-J.; Hsu J.-L.; Ho Y.-F.; LIH-CHING HSU ; Chang Y.-J.; Chang H.-S.; Chen I.-S.; JIH-HWA GUH | Prostate | 25 | 22 | |
68 | 2013 | Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology | Chen C.-L.; Chang D.-M.; Chen T.-C.; Lee C.-C.; Hsieh H.-H.; Huang F.-C.; Huang K.-F.; JIH-HWA GUH ; JING-JER LIN ; Huang H.-S. | European Journal of Medicinal Chemistry | 35 | 34 | |
69 | 2013 | Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase i inhibitory properties | Lee C.-C.; Chang D.-M.; Huang K.-F.; Chen C.-L.; Chen T.-C.; Lo Y.; JIH-HWA GUH ; Huang H.-S. | Bioorganic and Medicinal Chemistry | 20 | 18 | |
70 | 2012 | Bioactive diterpenes from Callicarpa longissima | Liu Y.-W.; Cheng Y.-B.; Liaw C.-C.; Chen C.-H.; JIH-HWA GUH ; Hwang T.-L.; Tsai J.-S.; WON-BO WANG ; Shen Y.-C. | Journal of Natural Products | 34 | 31 | |
71 | 2012 | Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair | Hsu J.-L.; Leong P.-K.; Ho Y.-F.; LIH-CHING HSU ; Lu P.-H.; Chen C.-S.; JIH-HWA GUH | Cancer Letters | 23 | 17 | |
72 | 2012 | Pycnidione, a fungus-derived agent, induces cell cycle arrest and apoptosis in A549 human lung cancer cells | Che-Jen Hsiao; Shih-Hsin Hsiao; Wei-Lin Chen; JIH-HWA GUH ; George Hsiao; Yen-Ju Chan; Tzong-Huei Lee ; Chi-Li Chung | Chemico-Biological Interactions | 35 | 27 | |
73 | 2012 | Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives | Lee C.-C.; Huang K.-F.; Lin P.-Y.; Huang F.-C.; Chen C.-L.; Chen T.-C.; JIH-HWA GUH ; JING-JER LIN ; Huang H.-S. | European Journal of Medicinal Chemistry | 27 | 23 | |
74 | 2012 | Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines | Chen C.-H.; Liao C.-H.; Chang Y.-L.; JIH-HWA GUH ; Pan S.-L.; Teng C.-M. | Cancer Letters | 54 | 49 | |
75 | 2012 | Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis | Chen C.-N.; Hsiao C.-J.; SHOEI-SHENG LEE ; JIH-HWA GUH ; Chiang P.-C.; Huang C.-C.; Huang W.-J. | Natural Product Research | 26 | 22 | |
76 | 2012 | Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells | Yu C.-C.; Chiang P.-C.; Lu P.-H.; Kuo M.-T.; Wen W.-C.; Chen P.; JIH-HWA GUH | Journal of Nutritional Biochemistry | 67 | 61 | |
77 | 2012 | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway | Hsu J.-L.; Ho Y.-F.; TSAI-KUN LI ; Chen C.-S.; LIH-CHING HSU ; JIH-HWA GUH | Biochemical Pharmacology | 18 | 16 | |
78 | 2011 | Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer | Thangaraj S.; Tsao W.-S.; Luo Y.-W.; Lee Y.-J.; Chang C.-F.; Lin C.-C.; Uang B.-J.; Yu C.-C.; JIH-HWA GUH ; Teng C.-M. | Tetrahedron | 19 | 17 | |
79 | 2011 | Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors | Huang W.-J.; CHING-CHOW CHEN ; Chao S.-W.; Yu C.-C.; Yang C.-Y.; JIH-HWA GUH ; Lin Y.-C.; Kuo C.-I.; Yang P.; Chang C.-I. | European Journal of Medicinal Chemistry | 37 | 35 | |
80 | 2011 | ICAM-1 and AMPK regulate cell detachment and apoptosis by N-methyl-N'-nitro-N-nitrosoguanidine, a widely spread environmental chemical, in human hormone-refractory prostate cancers | Chen Y.-C.; Lu P.-H.; Hsu J.-L.; Yu C.-C.; JIH-HWA GUH | Toxicology and Applied Pharmacology | 8 | 8 | |
81 | 2011 | Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator | Lee K.-H.; Hsu E.-C.; JIH-HWA GUH ; Yang H.-C.; Wang D.; Kulp S.K.; Shapiro C.L.; Chen C.-S. | Journal of Biological Chemistry | 89 | 90 | |
82 | 2011 | WJ9708012 exerts anticancer activity through PKC-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells | Kuo T.-C.; Huang W.-J.; JIH-HWA GUH | Acta Pharmacologica Sinica | 8 | 7 | |
83 | 2011 | Anti-angiogenic effects and mechanism of prazosin | Liao C.-H.; JIH-HWA GUH ; SHIH-CHIEH CHUEH ; HONG-JENG YU | Prostate | 25 | 27 | |
84 | 2011 | Paclitaxel induces apoptosis through activation of nuclear protein kinase C-δ and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer | Lu P.-H.; Yu C.-C.; Chiang P.-C.; Chen Y.-C.; Ho Y.-F.; FAN-LU KUNG ; JIH-HWA GUH | Journal of Urology | 16 | 14 | |
85 | 2011 | Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer | Hsu J.-L.; Pan S.-L.; Ho Y.-F.; Hwang T.-L.; FAN-LU KUNG ; JIH-HWA GUH | Journal of Urology | 49 | 46 | |
86 | 2011 | A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways | Kuo T.-C.; Chiang P.-C.; Yu C.-C.; Nakagawa-Goto K.; Bastow K.F.; Lee K.-H.; JIH-HWA GUH | Biochemical Pharmacology | 18 | 15 | |
87 | 2010 | Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: The roles of NF-κB and crosstalk between the extrinsic and intrinsic apoptotic pathways | Huang C.-H.; JIH-HWA GUH ; Chen G.S.; Lu P.-H.; Chern J.-W. | Naunyn-Schmiedeberg's Archives of Pharmacology | 7 | 7 | |
88 | 2010 | Moscatilin repressed lipopolysaccharide-induced hif-1α accumulation and NF-κB activation in murine raw264.7 cells | Liu Y.-N.; Pan S.-L.; Peng C.-Y.; Huang D.-Y.; JIH-HWA GUH ; Chen C.-C.; Shen C.-C.; Teng C.-M. | Shock | 28 | 26 | |
89 | 2010 | Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways | Sun Y.-W.; Huang W.-J.; Hsiao C.-J.; Chen Y.-C.; Lu P.-H.; JIH-HWA GUH | Prostate | 14 | 12 | |
90 | 2010 | Cryptocaryone, a Natural Dihydrochalcone, Induces Apoptosis in Human Androgen Independent Prostate Cancer Cells by Death Receptor Clustering in Lipid Raft and Nonraft Compartments | Chen Y.-C.; FAN-LU KUNG ; Tsai I.-L.; Chou T.-H.; Chen I.-S.; JIH-HWA GUH | Journal of Urology | 29 | 31 | |
91 | 2010 | Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo | Tsai A.-C.; Pan S.-L.; Liao C.-H.; JIH-HWA GUH ; Wang S.-W.; Sun H.-L.; Liu Y.-N.; Chen C.-C.; Shen C.-C.; Chang Y.-L.; Teng C.-M. | Cancer Letters | 59 | 48 | |
92 | 2010 | Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways | Chiang P.-C.; Lin S.-C.; Pan S.-L.; CHING-HUA KUO ; Tsai I.-L.; Kuo M.-T.; Wen W.-C.; Chen P.; JIH-HWA GUH | Biochemical Pharmacology | 114 | 106 | |
93 | 2010 | The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo | Peng C.-Y.; Pan S.-L.; Pai H.-C.; Tsai A.-C.; JIH-HWA GUH ; Chang Y.-L.; Kuo S.-C.; Lee F.-Y.; Teng C.-M. | Shock | 5 | 5 | |
94 | 2010 | 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase | Chang W.-L.; Chang C.-S.; Chiang P.-C.; Ho Y.-F.; Liu J.-F.; Chang K.-W.; JIH-HWA GUH | British Journal of Pharmacology | 30 | 25 | |
95 | 2009 | abeo-taxane diterpenoids from the Taiwanese yew Taxus sumatrana | Wang S.-S.; Abd El-Razek M.H.; Chen Y.-G.; Chien C.-T.; JIH-HWA GUH ; Kuo Y.-H.; Shen Y.-C. | Chemistry and Biodiversity | 2 | 1 | |
96 | 2009 | Combined treatment with denbinobin and fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma Bxpc-3 Cells | CHIA-RON YANG ; JIH-HWA GUH ; Teng C.M.; Chen C.C.; Chen P.H. | British Journal of Pharmacology | 16 | 14 | |
97 | 2009 | Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: Role of cell-cycle arrest and GRP78 | Hsu J.-L.; Chiang P.-C.; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 34 | 30 | |
98 | 2009 | Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1α accumulation in RAW264.7 | Liu Y.-N.; Pan S.-L.; Liao C.-H.; Huang D.-Y.; JIH-HWA GUH ; Peng C.-Y.; Chang Y.-L.; Teng C.-M. | Shock | 67 | 58 | |
99 | 2008 | Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates | LING-WEI HSIN ; Wang H.-P.; Kao P.-H.; Lee O.; Chen W.-R.; Chen H.-W.; JIH-HWA GUH ; Chan Y.-L.; His C.-P.; Yang M.-S.; TSAI-KUN LI ; Lee C.-H. | Bioorganic and Medicinal Chemistry | 45 | 41 | |
100 | 2008 | Elucidation of susceptible factors to endoplasmic reticulum stress-mediated anticancer activity in human hepatocellular carcinoma | Chiang P.-C.; Hsu J.-L.; Yeh T.-C.; Pan S.-L.; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 8 | 6 | |
101 | 2008 | WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers | Hsiao C.-J.; TSAI-KUN LI ; Chan Y.-L.; LING-WEI HSIN ; Liao C.-H.; Lee C.-H.; Lyu P.-C.; JIH-HWA GUH | Biochemical Pharmacology | 35 | 32 | |
102 | 2008 | Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells | Chen T.-H.; Pan S.-L.; JIH-HWA GUH ; Chen C.-C.; Huang Y.-T.; Pai H.-C.; Teng C.-M. | Naunyn-Schmiedeberg's Archives of Pharmacology | 21 | 16 | |
103 | 2008 | New bioactive clerodane diterpenoids from the roots of Casearia membranacea | Chen C.-Y.; Cheng Y.-B.; Chen S.-Y.; Chien C.-T.; Kuo Y.-H.; JIH-HWA GUH ; Khalil A.T.; Shen Y.-C. | Chemistry and Biodiversity | 26 | 27 | |
104 | 2008 | Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-κB activity in vascular smooth-muscle cells | Peng C.-Y.; Pan S.-L.; Huang Y.-W.; JIH-HWA GUH ; Chang Y.-L.; Teng C.-M. | Naunyn-Schmiedeberg's Archives of Pharmacology | 42 | 39 | |
105 | 2008 | The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion | Pan S.L.; Tao K.Y.; JIH-HWA GUH ; Sun H.L.; Huang D.Y.; Chang Y.L.; Teng C.M. | Shock | 18 | 16 | |
106 | 2008 | Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress | Hsiao C.-J.; Ho Y.-F.; Hsu J.T.-A.; Chang W.-L.; Chen Y.-C.; Shen Y.-C.; Lyu P.-C.; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 9 | 9 | |
107 | 2008 | Moscatilin induces apoptosis in human colorectal cancer cells: A crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage | Chen T.-H.; Pan S.-L.; JIH-HWA GUH ; Liao C.-H.; Huang D.-Y.; Chen C.-C.; Teng C.-M. | Clinical Cancer Research | 51 | 41 | |
108 | 2008 | YC-1 induces heat shock protein 70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells | Liu Y.-N.; Pan S.-L.; Peng C.-Y.; Huang D.-Y.; JIH-HWA GUH ; Kuo S.-C.; Lee F.-Y.; Teng C.-M. | Shock | 12 | 10 | |
109 | 2008 | CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo | Wang S.-W.; Pan S.-L.; Huang Y.-C.; JIH-HWA GUH ; Chiang P.-C.; Huang D.-Y.; Kuo S.-C.; Lee K.-H.; Teng C.-M. | Molecular Cancer Therapeutics | 65 | 59 | |
110 | 2008 | YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway | Wu S.Y.; Pan S.L.; Chen T.H.; Liao C.H.; Huang D.Y.; JIH-HWA GUH ; Chang Y.L.; Kuo S.C.; Lee F.Y.; Teng C.M. | British Journal of Pharmacology | 25 | 25 | |
111 | 2007 | Four new briarane diterpenoids from the gorgonian coral Junceella fragilis | Shen Y.-C.; Chen Y.-H.; Hwang T.-L.; JIH-HWA GUH ; Khalil A.T. | Helvetica Chimica Acta | 39 | 33 | |
112 | 2007 | Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult | Yeh T.-C.; Chiang P.-C.; TSAI-KUN LI ; Hsu J.-L.; CHUN-JUNG LIN ; Wang S.-W.; Peng C.-Y.; JIH-HWA GUH | Biochemical Pharmacology | 123 | 110 | |
113 | 2007 | CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression | Wang S.-W.; Pan S.-L.; Peng C.-Y.; Huang D.-Y.; Tsai A.-C.; Chang Y.-L.; JIH-HWA GUH ; Kuo S.-C.; Lee K.-H.; Teng C.-M. | Cancer Letters | 24 | 22 | |
114 | 2007 | Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways | Chen Y.-C.; Lu P.-H.; Pan S.-L.; Teng C.-M.; Kuo S.-C.; Lin T.-P.; Ho Y.-F.; Huang Y.-C.; JIH-HWA GUH | Biochemical Pharmacology | 58 | 59 | |
115 | 2007 | Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway | Lu P.-H.; SHIH-CHIEH CHUEH ; FAN-LU KUNG ; Pan S.-L.; Shen Y.-C.; JIH-HWA GUH | European Journal of Pharmacology | 52 | 47 | |
116 | 2007 | Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle | Lin S.-C.; SHIH-CHIEH CHUEH ; Hsiao C.-J.; TSAI-KUN LI ; Chen T.-H.; Liao C.-H.; Lyu P.-C.; JIH-HWA GUH | Neoplasia | 61 | 58 | |
117 | 2007 | YC-1 inhibits HIF-1 expression in prostate cancer cells: Contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia | Sun H.-L.; Liu Y.-N.; Huang Y.-T.; Pan S.-L.; Huang D.-Y.; JIH-HWA GUH ; Lee F.-Y.; Kuo S.-C.; Teng C.-M. | Oncogene | 162 | 158 | |
118 | 2006 | Investigation of anti-tumor mechanisms of K2154: Characterization of tubulin isotypes, mitotic arrest and apoptotic machinery | Lu P.-H.; FAN-LU KUNG ; Kuo S.-C.; SHIH-CHIEH CHUEH ; JIH-HWA GUH | Naunyn-Schmiedeberg's Archives of Pharmacology | 8 | 8 | |
119 | 2006 | YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9 | Liu Y.-N.; Pan S.-L.; Peng C.-Y.; JIH-HWA GUH ; Huang D.-M.; Chang Y.-L.; Lin C.-H.; Pai H.-C.; Kuo S.-C.; Lee F.-Y.; Teng C.-M. | Journal of Pharmacology and Experimental Therapeutics | 39 | 33 | |
120 | 2006 | Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells | Huang Y.-T.; Huang D.-M.; SHIH-CHIEH CHUEH ; Teng C.-M.; JIH-HWA GUH | Cancer Letters | 87 | 79 | |
121 | 2006 | Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells | Chiang P.-C.; FAN-LU KUNG ; Huang D.-M.; TSAI-KUN LI ; Fan J.-R.; Pan S.-L.; Shen Y.-C.; JIH-HWA GUH | European Journal of Pharmacology | 23 | 24 | |
122 | 2005 | YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G 0-G1 in human hepatocellular carcinoma cells | Wang S.-W.; Pan S.-L.; JIH-HWA GUH ; Chen H.-L.; Huang D.-M.; Chang Y.-L.; Kuo S.-C.; Lee F.-Y.; Teng C.-M. | Journal of Pharmacology and Experimental Therapeutics | 47 | 47 | |
123 | 2005 | Three new taxane diterpenoids from Taxus sumatrana | Shen Y.-C.; Cheng K.-C.; Lin Y.-C.; Cheng Y.-B.; Khalil A.T.; JIH-HWA GUH ; Chien C.-T.; Teng C.-M.; Chang Y.-T. | Journal of Natural Products | 19 | 15 | |
124 | 2005 | Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma | Chiang P.-C.; CHUNG-LIANG CHIEN ; Pan S.-L.; WEN-PIN CHEN ; Teng C.-M.; Shen Y.-C.; JIH-HWA GUH | Journal of Hepatology | 44 | 38 | |
125 | 2005 | A potential role of YC-I on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models | Pan S.-L.; JIH-HWA GUH ; Peng C.-Y.; Chang Y.-L.; Cheng F.-C.; Chang J.-H.; Kuo S.-C.; Lee F.-Y.; Teng C.-H. | Thrombosis and Haemostasis | 32 | 31 | |
126 | 2005 | CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line | Huang Y.-T.; Huang D.-M.; JIH-HWA GUH ; Chen I.-L.; Tzeng C.-C.; Teng C.-M. | Journal of Biological Chemistry | 43 | 44 | |
127 | 2005 | Denbinobin-mediated anticancer effect in human K562 leukemia cells: Role in tubulin polymerization and Bcr-Abl activity | Huang Y.-C.; JIH-HWA GUH ; Teng C.-M. | Journal of Biomedical Science | 32 | 27 | |
128 | 2005 | YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells | Huang Y.-T.; Pan S.-L.; JIH-HWA GUH ; Chang Y.-L.; Lee F.-Y.; Kuo S.-C.; Teng C.-M. | Molecular Cancer Therapeutics | 45 | 43 | |
129 | 2005 | Induction of mitotic arrest and apoptosis in human prostate cancer PC-3 cells by evodiamine | Huang D.-M.; JIH-HWA GUH ; Huang Y.-T.; SHIH-CHIEH CHUEH ; Chiang P.-C.; Teng C.-M. | Journal of Urology | 49 | 44 | |
130 | 2005 | Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo | Liao C.-H.; Pan S.-L.; JIH-HWA GUH ; Chang Y.-L.; Pai H.-C.; Lin C.-H.; Teng C.-M. | Carcinogenesis | 122 | 117 | |
131 | 2005 | Two new sesquiterpene lactones from Ixeris chinensis | Khalil A.T.; Shen Y.-C.; JIH-HWA GUH ; Cheng S.-Y. | Chemical and Pharmaceutical Bulletin | 16 | 14 | |
132 | 2005 | Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia | Huang Y.-C.; JIH-HWA GUH ; Shen Y.-C.; Teng C.-M. | Journal of Biomedical Science | 11 | 10 | |
133 | 2005 | YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models | Pan S.-L.; JIH-HWA GUH ; Peng C.-Y.; Wang S.-W.; Chang Y.-L.; Cheng F.-C.; Chang J.-H.; Kuo S.-C.; Lee F.-Y.; Teng C.-M. | Journal of Pharmacology and Experimental Therapeutics | 55 | 53 | |
134 | 2004 | New pentacyclic polyketide dimeric peroxides from a Taiwanese marine sponge Petrosia elastica | Shen Y.C.; Prakash C.V.S.; JIH-HWA GUH | Tetrahedron Letters | 14 | 12 | |
135 | 2004 | Armepavine oxalate induces cell death on CCRF-CEM leukemia cell line through an apoptotic pathway | Jow G.-M.; Wu Y.-C.; JIH-HWA GUH ; Teng C.-M. | Life Sciences | 13 | 12 | |
136 | 2004 | New Cytotoxic Clerodane Diterpenoids from the Leaves and Twigs of Casearia membranacea | Shen Y.-C.; Wang C.-H.; Cheng Y.-B.; Wang L.-T.; JIH-HWA GUH ; Chien C.-T.; Khalil A.T. | Journal of Natural Products | 49 | 47 | |
137 | 2004 | Modulation of Anti-Adhesion Molecule MUC-1 Is Associated with Arctiin-Induced Growth Inhibition in PC-3 Cells | Huang D.-M.; JIH-HWA GUH ; SHIH-CHIEH CHUEH ; Teng C.-M. | Prostate | 25 | 22 | |
138 | 2004 | Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells | Huang Y.-T.; SHIH-CHIEH CHUEH ; Teng C.-M.; JIH-HWA GUH | Biochemical Pharmacology | 101 | 93 | |
139 | 2004 | Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes | Huang Y.-C.; JIH-HWA GUH ; Teng C.-M. | Life Sciences | 64 | 59 | |
140 | 2004 | Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells | Liao C.-H.; Pan S.-L.; JIH-HWA GUH ; Teng C.-M. | Biochemical Pharmacology | 31 | 27 | |
141 | 2004 | Flavonol glycosides and cytotoxic triterpenoids from Alphitonia philippinensis | Jou S.-J.; Chen C.-H.; JIH-HWA GUH ; Lee C.-N.; SHOEI-SHENG LEE | Journal of the Chinese Chemical Society | 34 | 32 | |
142 | 2004 | Two new cytotoxic clerodane diterpenoids from Casearia membranacea | Shen Y.-C.; Wang L.-T.; Wang C.-H.; Khalil A.T.; JIH-HWA GUH | Chemical and Pharmaceutical Bulletin | 35 | 35 | |
143 | 2004 | Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells | Huang D.-M.; Shen Y.-C.; Wu C.; Huang Y.-T.; FAN-LU KUNG ; Teng C.-M.; JIH-HWA GUH | European Journal of Pharmacology | 48 | 45 | |
144 | 2004 | The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury | Peng C.-Y.; Pan S.-L.; JIH-HWA GUH ; Liu Y.-N.; Chang Y.-L.; Kuo S.-C.; Lee F.-Y.; Teng C.-M. | Thrombosis and Haemostasis | 21 | 21 | |
145 | 2004 | New Prostanoids with Cytotoxic Activity from Taiwanese Octocoral Clavularia viridis | Shen Y.-C.; Cheng Y.-B.; Lin Y.-C.; JIH-HWA GUH ; Teng C.-M.; Ko C.-L. | Journal of Natural Products | 46 | 42 | |
146 | 2004 | YC-1 prevents sodium nitroprusside-mediated apoptosis in vascular smooth muscle cells | Pan S.L.; JIH-HWA GUH ; Chang Y.L.; Kuo S.C.; Lee F.Y.; Teng C.M. | Cardiovascular Research | 36 | 32 | |
147 | 2003 | Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells | Chou J.-Y.; Lai S.-Y.; Pan S.-L.; Jow G.-M.; Chern J.-W.; JIH-HWA GUH | Biochemical Pharmacology | 147 | 123 | |
148 | 2003 | Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats | Pan S.-L.; Huang Y.-W.; JIH-HWA GUH ; Chang Y.-L.; Peng C.-Y.; Teng C.-M. | Biochemical Pharmacology | 67 | 62 | |
149 | 2003 | Potentiation of tumor necrosis factor-α expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway | Hwang T.-L.; Wu C.-C.; JIH-HWA GUH ; Teng C.-M. | Biochemical Pharmacology | 21 | 17 | |
150 | 2003 | Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells | Chou C.C.; Pan S.L.; Teng C.M.; JIH-HWA GUH | European Journal of Pharmaceutical Sciences | 85 | 76 | |
151 | 2003 | A novel secobetulinic acid 3,4-lactone from Viburnum aboricolum | Ku Y.-L.; Rao G.V.; Chen C.-H.; Wu C.; JIH-HWA GUH ; SHOEI-SHENG LEE | Helvetica Chimica Acta | 15 | 12 | |
152 | 2003 | Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells | Pan S.-L.; JIH-HWA GUH ; Huang Y.-W.; Chern J.-W.; Chou J.-Y.; Teng C.-M. | Journal of Urology | 27 | 25 | |
153 | 2002 | Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer | Huang D.-M.; JIH-HWA GUH ; Huang Y.-T.; SHIH-CHIEH CHUEH ; Wang H.-P.; Teng C.-M. | Journal of biomedical science | 12 | 12 | |
154 | 2002 | Characterization of some novel α1-adrenoceptor antagonists in human hyperplastic prostate | SHIH-CHIEH CHUEH ; Chern J.-W.; Choong C.-M.; JIH-HWA GUH ; Teng C.-M. | European Journal of Pharmacology | 6 | 6 | |
155 | 2002 | 1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis | Lien J.-C.; Lee F.-Y.; Huang L.-J.; Pan S.-L.; JIH-HWA GUH ; Teng C.-M.; Kuo S.-C. | Journal of Medicinal Chemistry | 27 | 23 | |
156 | 2002 | Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde | Pan S.-L.; JIH-HWA GUH ; Huang Y.-W.; Chang Y.-L.; Chang C.-Y.; Huang L.-J.; Kuo S.-C.; Teng C.-M. | Journal of biomedical science | 11 | 9 | |
157 | 2002 | Effect of a potent cyclooxygenase inhibitor, 5-ethyl-4-methoxy-2-phenylquinoline (KTC-5), on human platelets | Liao C.-H.; Chang Y.-L.; JIH-HWA GUH ; Kuo S.-C.; Huang L.-J.; Teng C.-M. | Journal of Pharmacy and Pharmacology | 3 | 3 | |
158 | 2001 | Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: Involvement of IκB-α stabilization | Huang Y.C.; JIH-HWA GUH ; Cheng Z.J.; Chang Y.L.; Hwang T.L.; Liao C.H.; Tzeng C.C.; Teng C.M. | European Journal of Pharmacology | 10 | 8 | |
159 | 2001 | Dual effects of ouabain on the regulation of proliferation and apoptosis in human prostatic smooth muscle cells | SHIH-CHIEH CHUEH ; JIH-HWA GUH ; Chen J.; Lai M.-K.; Teng C.-M. | Journal of Urology | 80 | 78 | |
160 | 2001 | Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells | Huang Y.-C.; JIH-HWA GUH ; Cheng Z.-J.; Chang Y.-L.; Hwang T.-L.; Lin C.-N.; Teng C.-M. | Life Sciences | 39 | 36 | |
161 | 2000 | Effects of ouabain on tension response and [3H]noradrenaline release in human prostate | JIH-HWA GUH ; SHIH-CHIEH CHUEH ; Teng C.-M. | Journal of Urology | 5 | 5 | |
162 | 1999 | Investigation of the effects of some alkaloidal α1-adrenoceptor antagonists on human hyperplastic prostate | JIH-HWA GUH ; Hsieh C.-H.; Teng C.-M. | European Journal of Pharmacology | 14 | 11 | |
163 | 1998 | Retraction: Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells (Biochemical Journal (1995) 306 (787-792)) | Cheng, Zhijiao; JIH-HWA GUH ; Lee, Fangyu; Kuo, Shengchen | Biochemical Journal | | | |
164 | 1998 | Erratum: Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells (Circulation (1996) 94 (547-554)) | Yu S.-M.; Tsai S.-Y.; JIH-HWA GUH ; Ko F.-N.; Teng C.-M.; Ou J.T. | Circulation | 0 | 0 | |
165 | 1998 | Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells. | Cheng Z.J.; JIH-HWA GUH ; Lee F.Y.; Kuo S.C. | The Biochemical journal | 1 | 0 | |
166 | 1998 | Cell proliferation in human prostatic smooth muscle cells involves the modulation of protein kinase C isozymes | JIH-HWA GUH ; SHIH-CHIEH CHUEH ; Hwang T.L.; Chen J.; Teng C.M. | European Journal of Pharmacology | 16 | 16 | |
167 | 1998 | Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor | JIH-HWA GUH ; Hwang T.-L.; Ko F.-N.; SHIH-CHIEH CHUEH ; Lai M.-K.; Teng C.-M. | Molecular Pharmacology | 75 | 68 | |
168 | 1997 | Correction: Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells (Biochemical Journal (1995) 306 (787-792)) | Yu S.M.; Cheng Z.J.; JIH-HWA GUH ; Lee F.Y.; Kuo S.C. | Biochemical Journal | 1 | 0 | |
169 | 1996 | Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells | Yu S.-M.; Tsai S.-Y.; JIH-HWA GUH ; Ko F.-N.; Teng C.-M.; Ou J.T. | Circulation | 87 | 82 | |
170 | 1996 | Ouabain-induced increases in resting tone of human hyperplastic prostate following repeated noradrenaline and electrical field stimulation | JIH-HWA GUH ; Ko F.-N.; SHIH-CHIEH CHUEH ; Lai M.-K.; Teng C.-M. | British Journal of Pharmacology | 8 | 8 | |
171 | 1996 | Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens | JIH-HWA GUH ; Yu S.-M.; Ko F.-N.; Wu T.S.; Teng C.-M. | European Journal of Pharmacology | 61 | 56 | |
172 | 1996 | Inhibition by tamsulosin of tension responses of human hyperplastic prostate to electrical field stimulation | SHIH-CHIEH CHUEH ; JIH-HWA GUH ; Chen J.; Lai M.-K.; Ko F.-N.; Teng C.-M. | European Journal of Pharmacology | 26 | 24 | |
173 | 1995 | CSH72—A Specific Antagonist of Platelet?activating Factor in Rabbit Platelets | JIH-HWA GUH ; KO F.?N.; LEE C.?S.; TENG C.?M. | Pharmacy and Pharmacology Communications | 0 | 0 | |
174 | 1995 | Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells | Yu S.M.; Cheng Z.J.; JIH-HWA GUH ; Lee F.Y.; Kuo S.C. | Biochemical Journal | 24 | 24 | |
175 | 1995 | Antiplatelet Effect of Gingerol Isolated from Zingiber officinale | JIH-HWA GUH ; KO F.?N.; JONG T.?T.; TENG C.?M. | Journal of Pharmacy and Pharmacology | 94 | 65 | |
176 | 1995 | Characterization of α1?adrenoceptor subtypes in tension response of human prostate to electrical field stimulation | JIH-HWA GUH ; SHIH-CHIEH CHUEH ; Ko F.?N.; Teng C.?M. | British Journal of Pharmacology | 43 | 43 | |
177 | 1995 | Pharmacological evaluation of N-methyl-actinodaphnine, a new vascular α-adrenoceptor antagonist, isolated from Illigera luzonensis | JIH-HWA GUH ; Ko F.-N.; Yu S.-M.; Wu Y.-C.; Teng C.-M. | European Journal of Pharmacology | 19 | 16 | |
178 | 1994 | Functional identification of α1-adrenoceptor subtypes in human prostate: comparison with those in rat vas deferens and spleen | Teng C.-M.; JIH-HWA GUH ; Ko F.-N. | European Journal of Pharmacology | 37 | 34 | |
179 | 1994 | (−)‐Discretamine, a selective α1D‐adrenoceptor antagonist, isolated from Fissistigma glaucescens | Ko F.-N.; JIH-HWA GUH ; Yu S.-M.; Hou Y.-S.; Wu Y.-C.; CHE-MING TENG | British Journal of Pharmacology | 79 | 72 | |