研究成果



第 1 到 48 筆結果,共 48 筆。

公開日期標題作者來源出版物scopusWOS全文
12023One-pot tandem reduction and site-selective halogenation of nitroarenesDhandabani, Ganesh Kumar; Chang, Li-Te; Hsieh, Hao-Yu; Shih, Chia-Ling; LING-WEI HSIN Organic & biomolecular chemistry
22023Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activitiesChu, Jung-Chun; Tseng, Hui-Ju; Lee, Sung-Bau; Hsu, Kai-Cheng; LING-WEI HSIN ; Liang, Ru-Hao; Lin, Tony Eight; Gao, Nain-Chu; Chen, Liang-Chieh; Lu, Wan-Hsun; Wang, Andrew H-J; Huang, Wei-JanJournal of enzyme inhibition and medicinal chemistry
320225-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndromeChang, Wen-Ying; Yang, Yi-Ting; She, Meng-Ping; CHIA-HUNG TU ; Lee, Tsung-Chun; Wu, Ming-Shiang; CHIN-HUNG SUN ; LING-WEI HSIN ; LINDA CHIA-HUI YU Laboratory investigation; a journal of technical methods and pathology76
42021Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavityPeng, Cheng; Li, Yu-Hsuan; CHAO-WU YU ; Cheng, Ze-Hua; Liu, Jia-Rong; Hsu, Jui-Ling; LING-WEI HSIN ; Huang, Chen-Tsung; HSUEH-FEN JUAN ; JI-WANG CHERN ; YI-SHENG CHENG Bioorganic Chemistry32
52021Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitorsHsu K.-C.; Chu J.-C.; Tseng H.-J.; Liu C.-I.; Wang H.-C.; Lin T.E.; Lee H.-S.; LING-WEI HSIN ; Wang A.H.-J.; Lin C.-H.; Huang W.-J.European Journal of Medicinal Chemistry76
62020Synthesis and analysis of 4-(3-fluoropropyl)-glutamic acid stereoisomers to determine the stereochemical purity of (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) for clinical useShih, Kai-Ting; Huang, Ya-Yao; Yang, Chia-Ying; MEI-FANG CHENG ; YU-WEN TIEN ; Shiue, Chyng-Yann; RUOH-FANG YEN ; LING-WEI HSIN PloS one44
72020Synthesis and evaluation of 2-(2′-((dimethylamino)methyl)-4′-(2-fluoroethoxy-substituted)phenylthio)benzenamine derivatives as potential positron emission tomography imaging agents for serotonin transportersHuang Y.-Y.; Chang L.-T.; Shen H.-Y.; Chen Y.-H.; KAI-YUAN TZEN ; Shiue C.-Y.; LING-WEI HSIN Bioorganic Chemistry00
82019High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastomaLiu, J.-R.; CHAO-WU YU ; Hung, P.-Y.; LING-WEI HSIN ; JE-RUEI LIU Biochemical Pharmacology5748
92019A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemiaLee S.-Y.; LING-WEI HSIN ; MING-JAI SU ; ChangChien C.-C.; Ku H.-C.Pharmacological Reports44
102019Prospective comparison of (4S)-4-(3- 18 F-fluoropropyl)-l-glutamate versus 18 F-fluorodeoxyglucose PET/CT for detecting metastases from pancreatic ductal adenocarcinoma: a proof-of-concept studyMEI-FANG CHENG ; Huang Y.-Y.; Ho B.-Y.; TING-CHUN KUO ; LING-WEI HSIN ; Shiue C.-Y.; Kuo H.-C.; YUNG-MING JENG ; RUOH-FANG YEN ; YU-WEN TIEN European Journal of Nuclear Medicine and Molecular Imaging1511
112019An one-pot two-step automated synthesis of [18F]T807 injection, its biodistribution in mice and monkeys, and a preliminary study in humansHuang Y.-Y.; MING-JANG CHIU et al. ; RUOH-FANG YEN ; Tsai C.-L.; Hsieh H.-Y.; Chiu C.-H.; Wu C.-H.; LING-WEI HSIN ; KAI-YUAN TZEN ; Cheng C.-Y.; Ma K.-H.; Shiue C.-Y.PLoS ONE23
122017Targeting breast cancer stem cells by novel HDAC3-selective inhibitorsHsieh H.-Y.; Chuang H.-C.; Shen F.-H.; Detroja K.; LING-WEI HSIN ; Chen C.-S.European Journal of Medicinal Chemistry5451
132017Identification of Buctopamine and Mebuctopamine, a β2 Receptor Agonist and Its Metabolite, in Swine Hair and Feed AdditivesChen Y.-H.; Yang C.-Y.; Cheng C.W.; Lin Y.-Y.; Kuo S.L.; LING-WEI HSIN Journal of Agricultural and Food Chemistry23
142017Fast and Facile Synthesis of 4-Nitrophenyl 2-Azidoethylcarbamate Derivatives from N-Fmoc-Protected α-Amino Acids as Activated Building Blocks for Urea Moiety-Containing Compound LibraryChen Y.-Y.; Chang L.-T.; Chen H.-W.; Yang C.-Y.; LING-WEI HSIN ACS Combinatorial Science77
152016A Novel potential positron emission tomography imaging agent for vesicular monoamine transporter type 2Huang Z.-R.; Tsai C.-L.; Huang Y.-Y.; Shiue C.-Y.; KAI-YUAN TZEN ; RUOH-FANG YEN ; LING-WEI HSIN PLoS ONE53
162016Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brainFreyberg Z.; Sonders M.S.; Aguilar J.I.; Hiranita T.; Karam C.S.; Flores J.; Pizzo A.B.; Zhang Y.; Farino Z.J.; Chen A.; Martin C.A.; Kopajtic T.A.; Fei H.; Hu G.; Lin Y.-Y.; Mosharov E.V.; McCabe B.D.; Freyberg R.; Wimalasena K.; LING-WEI HSIN ; Sames D.; Krantz D.E.; Katz J.L.; Sulzer D.; Javitch J.A.Nature Communications8679
172015Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancersHsieh M.-H.; Tsai C.-H.; Hung J.-J.; TSAI-KUN LI ; SHU-CHUN TENG ; Chang L.-T.; LING-WEI HSIN ; Teng S.-C.Cellular and Molecular Life Sciences89
182015Activation of serotonin 5-HT7 receptor induces coronary flow increase in isolated rat heartChang Chien C.-C.; LING-WEI HSIN ; MING-JAI SU European Journal of Pharmacology1210
192013Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's diseaseCHAO-WU YU ; Chang P.-T.; LING-WEI HSIN ; Chern J.-W.Journal of Medicinal Chemistry8982
202012Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profilesLee C.-H.; Hsieh M.-Y.; LING-WEI HSIN ; Chen H.-C.; Lo S.-C.; Fan J.-R.; Chen W.-R.; Chen H.-W.; NEI-LI CHAN ; TSAI-KUN LI Biochemical Pharmacology1212
212010Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7, 7a-octahydro-1H-benzofuro[3,2-e]isoquinolinesLING-WEI HSIN ; Chang L.-T.; Rothman R.B.; Dersch C.M.; Fishback J.A.; Matsumoto R.R.Journal of Medicinal Chemistry1211
222010Improved enamine-type addition of dehydroaporphine using microwave irradiationHuang W.-J.; Huang C.-C.; LING-WEI HSIN ; Tsai Y.-M.; Lin C.-T.; Lin J.-H.; SHOEI-SHENG LEE Tetrahedron Letters22
232010Identification of a novel almost neutral μ-opioid receptor antagonist in CHO cells expressing the cloned human μ-opioid receptorSally E.J.; Xu H.; Dersch C.M.; LING-WEI HSIN ; Chang L.-T.; Prisinzano T.E.; Simpson D.S.; Giuvelis D.; Rice K.C.; Jacobson A.E.; Cheng K.; Bilsky E.J.; Rothman R.B.Synapse22
242008WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancersHsiao C.-J.; TSAI-KUN LI ; Chan Y.-L.; LING-WEI HSIN ; Liao C.-H.; Lee C.-H.; Lyu P.-C.; JIH-HWA GUH Biochemical Pharmacology3532
252008Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transportersLING-WEI HSIN ; Chang L.-T.; Rothman R.B.; Dersch C.M.; Jacobson A.E.; Rice K.C.Journal of Medicinal Chemistry1110
262008A practical asymmetric synthesis of the ACNO fragment of morphine alkaloidsLING-WEI HSIN ; Chang L.-T.; Liou H.-L.Synlett76
272008Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugatesLING-WEI HSIN ; Wang H.-P.; Kao P.-H.; Lee O.; Chen W.-R.; Chen H.-W.; JIH-HWA GUH ; Chan Y.-L.; His C.-P.; Yang M.-S.; TSAI-KUN LI ; Lee C.-H.Bioorganic and Medicinal Chemistry4541
282005Stereoselective synthesis of morphine fragments trans- and cis-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolinesLING-WEI HSIN ; Chang L.-T.; Chen C.-W.; Hsu C.-H.; Chen H.-W.Tetrahedron1514
292005Asymmetric total synthesis of (-)-octahydro-1H-benzofuro[3,2-e] isoquinoline, a partial structure of morphineLING-WEI HSIN ; Chen C.-W.; Chang L.-T.Journal of the Chinese Chemical Society33
302005The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in ratsJutkiewicz E.M.; Wood S.K.; Houshyar H.; LING-WEI HSIN ; Rice K.C.; Woods J.H.Psychopharmacology7367
312004Intramolecular Heck cyclization to the galanthamine-type alkaloids: Total synthesis of (±)-lycoraminePI-HUI LIANG ; Liu, Jing Ping; LING-WEI HSIN ; Cheng, Chen YuTetrahedron
322004Synthesis of 3-[4-acyl-2-(1-methoxy-1-methylethyl)morpholin-3-yl]- benzonitriles as novel potassium channel openersLin M.-S.; LING-WEI HSIN ; Cheng C.-Y.Journal of the Chinese Chemical Society02
332003Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agentsLING-WEI HSIN ; Prisinzano T.; Wilkerson C.R.; Dersch C.M.; Horel R.; Jacobson A.E.; Rothman R.B.; Rice K.C.Bioorganic and Medicinal Chemistry Letters1614
342003Synthesis of galanthamine analogs as acetylcholinesterase inhibitors via intramolecular heck cvclizationPI-HUI LIANG ; LING-WEI HSIN ; Pong S.-L.; Hsu C.-H.; Cheng C.-Y.Journal of the Chinese Chemical Society1212
352003A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleatePrisinzano T.; LING-WEI HSIN ; Folk J.E.; Flippen-Anderson J.L.; George C.; Jacobson A.E.; Rice K.C.Tetrahedron Asymmetry1211
362002Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: Chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenylpropyl)piperazineLING-WEI HSIN ; Dersch C.M.; Baumann M.H.; Stafford D.; Glowa J.R.; Rothman R.B.; Jacobson A.E.; Rice K.C.Journal of Medicinal Chemistry6764
372002Synthesis of 1,4-dihydro-2-phenyl-4,4-bis(4-pyridinylmethyl)-2H-isoquinolin-3-one and related compounds as acetylcholine release enhancersLin M.-S.; LING-WEI HSIN ; Tsai H.-B.; Tsai M.-C.; Cheng C.-Y.Chinese Pharmaceutical Journal2
382002CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonistsLING-WEI HSIN ; Tian X.; Webster E.L.; Coop A.; Caldwell T.M.; Jacobson A.E.; Chrousos G.P.; Gold P.W.; Habib K.E.; Ayala A.; Eckelman W.C.; Contoreggi C.; Rice K.C.Bioorganic and Medicinal Chemistry36
392002N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openersPI-HUI LIANG ; LING-WEI HSIN ; Cheng, Chen-YuBioorganic and Medicinal Chemistry32
402001The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type 1Tian X.; LING-WEI HSIN ; Webster E.L.; Contoreggi C.; Chrousos G.P.; Gold P.W.; Habib K.; Ayala A.; Eckelman W.C.; Jacobson A.E.; Rice K.C.Bioorganic and Medicinal Chemistry Letters2018
412000Synthesis of [3H](4-fluorobutyl)propyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine: A potent radioligand for corticotropin-releasing hormone type 1 receptorLING-WEI HSIN ; Webster E.L.; Chrousos G.P.; Gold P.W.; Eckelman W.C.; Contoreggi C.; Rice K.C.Journal of Labelled Compounds and Radiopharmaceuticals12
422000Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptorLING-WEI HSIN ; Webster E.L.; Chrousos G.P.; Gold P.W.; Eckelman W.C.; Contoreggi C.; Rice K.C.Bioorganic and Medicinal Chemistry Letters2221
431999Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1- [2- [bis (4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agentsLewis D.B.; Matecka D.; Zhang Y.; LING-WEI HSIN ; Dersch C.M.; Stafford D.; Glowa J.R.; Rothman R.B.; Rice K.C.Journal of Medicinal Chemistry5854
441996Synthesis of 1,4-bis [(17-normorphinyl)methyl]cubane, a morphine dimer linked by cubaneCheng C.-Y.; LING-WEI HSIN ; Tao P.-L.Chinese Pharmaceutical Journal0
451996N-Cubylmethyl substituted morphinoids as novel narcotic antagonistsCheng C.-Y.; LING-WEI HSIN ; Lin Y.-P.; Tao P.-L.; Jong T.-T.Bioorganic and Medicinal Chemistry2625
461996Novel radical synthesis of morphine fragments spiro[benzofuran-3(2H),4'-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinolineCheng C.-Y.; LING-WEI HSIN ; Liou J.-P.Tetrahedron2421
471994Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-olsCheng C.-Y.; LING-WEI HSIN ; Tsai M.-C.; Schmidt W.K.; Smith C.; Tam S.W.Journal of Medicinal Chemistry1312
481992Selective Reversible and Irreversible Ligands for the k Opioid ReceptorCheng C.-Y.; Shou-Chien W.; LING-WEI HSIN ; Tam S.W.Journal of Medicinal Chemistry2220