研究成果


第 1 到 65 筆結果，共 65 筆。

公開日期標題作者來源出版物scopusWOS全文
12024Inhibition of resurgent Na+ currents by rufinamideChen, Jian-Lin; CHUNG-CHIN KUO Neuropharmacology
22024Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesisYang, Ya-Chin; Wang, Guan-Hsun; Chou, Ping; Hsueh, Shu-Wei; Lai, Yi-Chen; CHUNG-CHIN KUO Proceedings of the National Academy of Sciences of the United States of America
32022The genesis and functional consequences of cortico-subthalamic beta augmentation and excessive subthalamic burst discharges after dopaminergic deprivationLai, Hsing-Jung; Deng, Chuan-Rou; Wang, Ren-Wei; Lee, Lan-Hsin Nancy; CHUNG-CHIN KUO Experimental neurology10
42022Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activitiesLee, Lan-Hsin Nancy; Huang, Chen-Syuan; Wang, Ren-Wei; Lai, Hsing-Jung; Chung, Chih-Ching; Yang, Ya-Chin; CHUNG-CHIN KUO NPJ Parkinson's disease11
52022Selective stabilization of the intermediate inactivated Na+ channel by the new-generation anticonvulsant rufinamideLin Y.-C.; Lai Y.-C.; Lin T.-H.; Yang Y.-C.; CHUNG-CHIN KUO Biochemical Pharmacology11
62021How Can an Na+ Channel Inhibitor Ameliorate Seizures in Lennox–Gastaut Syndrome?Lin Y.-C.; Lai Y.-C.; Chou P.; Hsueh S.-W.; Lin T.-H.; Huang C.-S.; Wang R.-W.; Yang Y.-C.; CHUNG-CHIN KUO Annals of Neurology53
72021An electrophysiological perspective on Parkinson’s disease: symptomatic pathogenesis and therapeutic approachesLee L.-H.N.; Huang C.-S.; Chuang H.-H.; Lai H.-J.; Yang C.-K.; Yang Y.-C.; CHUNG-CHIN KUO Journal of Biomedical Science117
82021Anticonvulsant vs. Proconvulsant Effect of in situ Deep Brain Stimulation at the Epileptogenic FocusChou P.; CHUNG-CHIN KUO Frontiers in Systems Neuroscience01
92021Glutamate transmission rather than cellular pacemaking propels excitatory-inhibitory resonance for ictogenesis in amygdalaWang G.-H.; Chou P.; Hsueh S.-W.; Yang Y.-C.; CHUNG-CHIN KUO Neurobiology of Disease65
102020Author Correction: Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders (Scientific Reports, (2020), 10, 1, (8278), 10.1038/s41598-020-65211-w)CHUN-HWEI TAI ; MING-KAI PAN ; SHENG-HONG TSENG ; Wang T.-R.; Chung-Chin Kuo Scientific Reports00
112020Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disordersCHUN-HWEI TAI ; MING-KAI PAN ; SHENG-HONG TSENG ; Wang T.-R.; Chung-Chin Kuo Scientific Reports77
122020Delta-Frequency Augmentation and Synchronization in Seizure Discharges and Telencephalic TransmissionChou P.; Wang G.-H.; Hsueh S.-W.; Yang Y.-C.; CHUNG-CHIN KUO iScience98
132020Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gateChen Y.-S.; Tu Y.-C.; Lai Y.-C.; Liu E.; Yang Y.-C.; Chung-Chin Kuo Journal of Neurochemistry31
142020Inhibition of neuronal Na+ currents by lacosamide: Differential binding affinity and kinetics to different inactivated statesPeng Y.-S.; Wu H.-T.; Lai Y.-C.; Chen J.-L.; Yang Y.-C.; CHUNG-CHIN KUO Neuropharmacology75
152019Anomalous enhancement of resurgent Na+ currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgiaHuang C.-W.; Lai H.-J.; Huang P.-Y.; MING-JEN LEE ; Chung-Chin Kuo Scientific Reports413
162019Temperature dependence of the biophysical mechanisms underlying the inhibition and enhancement effect of amiodarone on hERG channelssLo Y.-C.; Chung-Chin Kuo Molecular Pharmacology33
172016A synergistic blocking effect of Mg2+ and spermine on the inward rectifier K+ (Kir2.1) channel poreHuang C.-W.; Chung-Chin Kuo Scientific Reports65
182016Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor controlMING-KAI PAN ; Kuo, S.-H.; CHUN-HWEI TAI ; Liou, J.-Y.; Pei, J.-C.; Chang, C.-Y.; Wang, Y.-M.; Liu, W.-C.; Wang, T.-R.; WEN-SUNG LAI ; CHUNG-CHIN KUO Journal of Clinical Investigation3028
192016Modulation of NMDA channel gating by Ca2+ and Cd2+ binding to the external pore mouthTu Y.-C.; Yang Y.-C.; Chung-Chin Kuo Scientific Reports98
202016The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited ErythromelalgiaHuang C.-W.; Lai H.-J.; Huang P.-Y.; MING-JEN LEE ; Chung-Chin Kuo PLoS Biology106
212015The differential contribution of GluN1 and GluN2 to the gating operation of the NMDA receptor channelTu Y.-C.; Chung-Chin Kuo Pflugers Archiv European Journal of Physiology1010
222015The temporal profiles of changes in nerve excitability indices in familial amyloid polyneuropathyLai H.-J.; Chiang Y.-W.; Yang C.-C.; SUNG-TSANG HSIEH ; CHI-CHAO CHAO ; MING-JEN LEE ; Chung-Chin Kuo PLoS ONE1511
232015Driving force-dependent block by internal Ba2+ on the Kir2.1 channel: Mechanistic insight into inward rectificationHsieh C.-P.; Chung-Chin Kuo ; Huang C.-W.Biophysical Chemistry66
242015Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K+ (Kir2.1) channelHuang C.-W.; Chung-Chin Kuo Pflugers Archiv European Journal of Physiology66
252014The T-type calcium channel as a new therapeutic target for Parkinson's diseaseYang Y.-C.; CHUN-HWEI TAI ; MING-KAI PAN ; Chung-Chin Kuo Pflugers Archiv European Journal of Physiology4038
262014The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channelHuang C.-W.; Chung-Chin Kuo Pflugers Archiv European Journal of Physiology88
272014Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficitsMING-KAI PAN ; CHUN-HWEI TAI ; Liu, W.-C.; Pei, J.-C.; WEN-SUNG LAI ; CHUNG-CHIN KUO Journal of Clinical Investigation2726
282014Gating of the Kir2.1 Channel at the Bundle Crossing Region by Intracellular Spermine and Other CationsHuang C.-W.; Chung-Chin Kuo Journal of Cellular Physiology44
292012Subthalamic discharges as a causal determinant of parkinsonian motor deficitsCHUN-HWEI TAI ; MING-KAI PAN ; Lin J.J.; Huang C.-S.; Yang Y.-C.; Chung-Chin Kuo Annals of Neurology2825
302011Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson diseaseCHUN-HWEI TAI ; Yang Y.-C.; MING-KAI PAN ; Huang C.-S.; Chung-Chin Kuo Journal of Clinical Investigation5958
312011Functional extension of amino acid triads from the fourth transmembrane segment (S4) into its external linker in Shaker K + channelsYang Y.-C.; Lin S.; Chang P.-C.; Lin H.-C.; CHUNG-CHIN KUO Journal of Biological Chemistry55
322010Parkinson's disease and cortico-basal ganglia circuitsMING-KAI PAN ; CHUN-HWEI TAI ; CHUNG-CHIN KUO Acta Neurologica Taiwanica20
332010Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channelsYang Y.-C.; Huang C.-S.; Chung-Chin Kuo Anesthesiology4242
342010Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptorsYang Y.-C.; Lee C.-H.; Chung-Chin Kuo Journal of Physiology1312
352009The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channelYang Y.-C.; Hsieh J.-Y.; Chung-Chin Kuo Journal of General Physiology2623
362008Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptorChang H.-R.; Chung-Chin Kuo Journal of Medicinal Chemistry2113
372008The activation gate and gating mechanism of the NMDA receptorChang H.-R.; Chung-Chin Kuo Journal of Neuroscience8076
382007Characterization of the gating conformational changes in the felbamate binding site in NMDA channelsChang H.-R.; Chung-Chin Kuo Biophysical Journal1010
392007Extracellular proton-modulated pore-blocking effect of the anticonvulsant felbamate on NMDA channelsChang H.-R.; Chung-Chin Kuo Biophysical Journal64
402007A hydrophobic element secures S4 voltage sensor in position in resting Shaker K+ channelsYang Y.-C.; Own C.-J.; Chung-Chin Kuo Journal of Physiology1110
412006Electrophysiology of subthalamic nucleus in normal and Parkinson's diseaseCHUN-HWEI TAI ; CHUNG-CHIN KUO Acta Neurologica Taiwanica30
422005An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+Yang Y.-C.; Chung-Chin Kuo Journal of General Physiology2119
432004Use-Dependent Inhibition of the N-Methyl-D-aspartate Currents by Felbamate: A Gating Modifier with Selective Binding to the Desensitized ChannelsChung-Chin Kuo ; Lin B.-J.; Chang H.-R.; Hsieh C.-P.Molecular Pharmacology3529
442004Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: Gating modification and Na+ flow dependenceChung-Chin Kuo ; Chen Wan Yu; Yang Y.-C.Journal of General Physiology3128
452003The position of the fourth segment of domain 4 determines status of the inactivation gate in Na+ channelsYang Y.-C.; Chung-Chin Kuo Journal of Neuroscience2619
462002Effect of Na+ flow on Cd2+ block of tetrodotoxin-resistant Na+ channelsChung-Chin Kuo ; Lin T.-J.; Hsieh C.-P.Journal of General Physiology1615
472002Inhibition of Na + current by imipramine and related compounds: Different binding kinetics as an inactivation stabilizer and as an open channel blockerYang Y.-C.; Chung-Chin Kuo Molecular Pharmacology5552
482001Recovery from inactivation of T-type Ca2+ channels in rat thalamic neuronsChung-Chin Kuo ; Yang S.Journal of Neuroscience3232
492000Inhibition of Na+ current by diphenhydramine and other diphenyl compounds: Molecular determinants of selective binding to the inactivated channelsChung-Chin Kuo ; Huang R.-C.; Lou B.-S.Molecular Pharmacology8178
502000Facilitation of recovery from inactivation by external NA+ and location of the activation gate in neuronal NA+ channelsChung-Chin Kuo ; Liao S.-Y.Journal of Neuroscience2020
511999Zn2+ modulation of neuronal transient K+ current: Fast and selective binding to the deactivated channelsChung-Chin Kuo ; Chen F.-P.Biophysical Journal1718
521999K + binding sites and interactions between permeating K+ ions at the external pore mouth of an inward rectifier K+ channel (Kir2.1)Shieh R.-C.; Chang J.-C.; Chung-Chin Kuo Journal of Biological Chemistry1716
531998Imipramine inhibition of transient K+ current: An external open channel blocker preventing fast inactivationChung-Chin Kuo Biophysical Journal3031
541998A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channelsChung-Chin Kuo Molecular Pharmacology190163
551997Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neuronesChung-Chin Kuo ; LU LU British Journal of Pharmacology134120
561997Carbamazepine inhibition of neuronal Na+ currents: Quantitative distinction from phenytoin and possible therapeutic implicationsChung-Chin Kuo ; Chen R.-S.; LU LU ; Chen R.-C.Molecular Pharmacology145135
571997Deactivation retards recovery from inactivation in Shaker K+ channelsChung-Chin Kuo Journal of Neuroscience78
581995Postnatal development of cortical acetylcholinesterase-rich neurons in the rat brain: Permanent and transient patternsGeula C.; Mesulam M.-M.; Chung-Chin Kuo ; Tokuno H.Experimental Neurology2929
591994Na+ channels must deactivate to recover from inactivationChung-Chin Kuo ; Bean B.P.Neuron259253
601994Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neuronsChung-Chin Kuo ; Bean B.P.Molecular Pharmacology185176
611993Ion permeation through the L-type Ca2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore.Chung-Chin Kuo ; Hess P.The Journal of Physiology9899
621993Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells.Chung-Chin Kuo ; Hess P.The Journal of Physiology6160
631993G-protein modulation of ion permeation through N-type calcium channelsChung-Chin Kuo ; Bean B.P.Nature6068
641993Characterization of the high-affinity Ca2+ binding sites in the L-type Ca2+ channel pore in rat phaeochromocytoma cells.Chung-Chin Kuo ; Hess P.The Journal of Physiology8983
651992A functional view of the entrances of L-type Ca2+ channels: estimates of the size and surface potential at the pore mouthsChung-Chin Kuo ; Hess P.Neuron3034