研究成果


第 1 到 43 筆結果，共 43 筆。

公開日期標題作者來源出版物scopusWOS全文
12023CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resectionJaiswal, Rishi Kumar; Lei, Kai-Hang; Chastain, Megan; Wang, Yuan; Shiva, Olga; Li, Shan; You, Zhongsheng; HUNG-YUAN CHI ; Chai, WeihangNature communications0
22023RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleasesGuh, Chia-Lun; Lei, Kai-Hang; Chen, Yi-An; Jiang, Yi-Zhen; Chang, Hao-Yen; Liaw, Hungjiun; HUNG-WEN LI ; Yen, Hsin-Yung; HUNG-YUAN CHI Nucleic acids research00
32023An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real timeLee, Chih-Ying; WEN-FANG CHENG ; PO-HAN LIN ; YU-LI CHEN ; Huang, Shih-Han; Lei, Kai-Hang; Chang, Ko-Yu; Ko, Min-Yu; HUNG-YUAN CHI Cell reports. Medicine00
42023A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombinationLuo, Shih-Chi; Yeh, Min-Chi; Lien, Yu-Hsiang; Yeh, Hsin-Yi; Siao, Huei-Lun; Tu, I-Ping; HUNG-YUAN CHI ; Ho, Meng-ChiaoNature communications00
52022Comparison of ATP-binding pockets and discovery of homologous recombination inhibitorsBlay, Vincent; Gailiunaite, Saule; Lee, Chih-Ying; Chang, Hao-Yen; Hupp, Ted; Houston, Douglas R; HUNG-YUAN CHI Bioorganic & medicinal chemistry00
62021Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulationWEI-TING CHEN; Tseng, Huan Yi; Jiang, Chung Lin; Lee, Chih Ying; Chi, Peter ; Chen, Liuh Yow; KAI-YIN LO ; Wang, I. ChingJournal of Biomedical Science44
72021Caenorhabditis elegans DSB-3 reveals conservation and divergence among protein complexes promoting meiotic double-strand breaksHinman, Albert W.; Yeh, Hsin Yi; Roelens, Baptiste; Yamaya, Kei; Woglar, Alexander; Bourbon, Henri Marc G.; Chi, Peter ; Villeneuve, Anne M.Proceedings of the National Academy of Sciences of the United States of America1612
82021Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequencesLi, Wan Chen; Lee, Chia Yi; Lan, Wei Hsuan; Woo, Tai Ting; Liu, Hou Cheng; Yeh, Hsin Yi; Chang, Hao Yen; Chuang, Yu Chien; Chen, Chiung Ya; Chuang, Chi Ning; Chen, Chia Ling; Hsueh, Yi Ping; HUNG-WEN LI ; Chi, Peter ; Wang, Ting FangProceedings of the National Academy of Sciences of the United States of America99
92021Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNALyu, X.; Lei, K.H.; Biak Sang, P.; Shiva, O.; Chastain, M.; Chi, P. ; Chai, W.The EMBO Journal1518
102021Crosstalk between CST and RPA regulates RAD51 activity during replication stressLei K.-H; Yang H.-L; Chang H.-Y; Yeh H.-Y; Nguyen D.D; Lee T.-Y; Lyu X; Chastain M; Chai W; Li H.-W; Chi P. ; HUNG-WEN LI Nature Communications75
112021Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structuresHUNG-WEN LI ; HUNG-YUAN CHI Nature Communications1213
122020Microcephaly family protein MCPH1 stabilizes RAD51 filamentsChang, H.-Y.; Lee, C.-Y.; Lu, C.-H.; Lee, W.; Yang, H.-L.; Yeh, H.-Y.; Li, H.-W.; HUNG-YUAN CHI ; HUNG-WEN LI Nucleic acids research65
132020Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinaseLan, Wei-Hsuan; Lin, Sheng-Yao; Kao, Chih-Yuan; Chang, Wen-Hsuan; Yeh, Hsin-Yi; Chang, Hao-Yen; Chi, Peter; Stathes Paganis ; HUNG-YUAN CHI ; HUNG-WEN LI Proceedings of the National Academy of Sciences1514
142019Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processesKlein, Hannah L.; Ang, Kenny K. H.; Arkin, Michelle R.; Beckwitt, Emily C.; Chang, Yi-Hsuan; Fan, Jun; Kwon, Youngho; Morten, Michael J.; Mukherjee, Sucheta; Pambos, Oliver J.; Sayyed, Hafez El; Thrall, Elizabeth S.; Vieira-Da-Rocha, João P.; Wang, Quan; Wang, Shuang; Yeh, Hsin-Yi; Biteen, Julie S.; HUNG-YUAN CHI ; Heyer, Wolf-Dietrich; Kapanidis, Achillefs N.; Loparo, Joseph J.; Strick, Terence R.; Sung, Patrick; Van Houten, Bennett; Niu, Hengyao; Rothenberg, EliMicrobial Cell98
152018Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociationC. H. Lu; H. Y. Yeh; G. C. Su; K. Ito; Y. Kurokawa; H. Iwasaki; P. Chi ; HUNG-WEN LI Proceedings of the National Academy of Sciences of the United States of America2318
162017Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegansYeh, H.-Y.; Lin, S.-W.; Wu, Y.-C. ; NEI-LI CHAN ; P. Chi Scientific Reports44
172017Mobilizing transit-amplifying cell-derived ectopic progenitors prevents hair loss from chemotherapy or radiation therapyHuang W.-Y.; SHIH-FAN LAI ; HSIEN-YI CHIU ; Chang M.; Plikus M.V.; CHIH-CHIEH CHAN ; YOU-TZUNG CHEN ; PO-NIEN TSAO ; TSUNG-LIN YANG ; Lee, Hsuan-Shu ; Chi P. ; SUNG-JAN LIN Cancer Research3025
182016Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombinationG. C. Su; H. Y. Yeh; S. W. Lin; C. I. Chung; Y. S. Huang; Y. C. Liu; P. C. Lyu; P. Chi Nucleic Acids Research119
192016Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancerA. Chao; T. C. Chang; N. Lapke; S. M. Jung; P. Chi ; C. H. Chen; L. Y. Yang; C. T. Lin; H. J. Huang; H. H. Chou; J. D. Liou; S. J. Chen; T. H. Wang; C. H. LaiOncotarget3939
202015Functional relationship of ATP hydrolysis, presynaptic filament stability, and homologous DNA pairing activity of the human meiotic recombinase DMC1Chang, Hao-Yen; Liao, Chia-Yu; Su, Guan-Chin; Lin, Sheng-Wei; Wang, Hong-Wei; HUNG-YUAN CHI Journal of Biological Chemistry1311
212014Purification of recombinant nacre-associated mineralization protein AP7 fused with maltose-binding proteinHuang, Y.-C.; Chang, H.-H.; Mou, Y.; Chi, P.; Chan, J.C.C. ; HUNG-YUAN CHI Protein Expression and Purification22
222014Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complexSu, G.-C.; Chung, C.-I.; Liao, C.-Y.; Lin, S.-W.; Tsai, C.-T.; Huang, T.; Li, H.-W.; Chi, P.; HUNG-WEN LI ; HUNG-YUAN CHI Nucleic Acids Research2322
232014Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairingZhao, Weixing; Saro, Dorina; Hammel, Michal; Kwon, Youngho; Xu, Yuanyuan; Rambo, Robert P.; Williams, Gareth J.; HUNG-YUAN CHI ; Lu, Lucy; Pezza, Roberto J.; Camerini-Otero, R. Daniel; Tainer, John A.; Wang, Hong-Wei; Sung, PatrickNucleic Acids Research4242
242013Functional attributes of the Saccharomyces cerevisiae meiotic recombinase Dmc1Busygina, Valeria; Gaines, William A.; Xu, Yuanyuan; Kwon, Youngho; Williams, Gareth J.; Lin, Sheng-Wei; Chang, Hao-Yen; HUNG-YUAN CHI ; Wang, Hong-Wei; Sung, PatrickDNA Repair1716
252013Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migrationWilson, Marenda A.; Kwon, Youngho; Xu, Yuanyuan; Chung, Woo-Hyun; HUNG-YUAN CHI ; Niu, Hengyao; Mayle, Ryan; Chen, Xuefeng; Malkova, Anna; Sung, Patrick; Ira, GrzegorzNature239224
262012Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint ResponseChen, Chia-Hsin; Chu, Po-Chen; Lee, Liekyeow; Lien, Huang-Wei; Lin, Tse-Ling; Fan, Chi-Chen; Chi, Peter ; Huang, Chang-Jen; Chang, Mau-Sun ; Schmidt, Edward E.PLoS ONE1817
272012Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complexTsai, Shang-Pu; Su, Guan-Chin; Lin, Sheng-Wei; Chung, Chan-I.; Xue, Xiaoyu; Dunlop, Myun Hwa; Akamatsu, Yufuko; Jasin, Maria; Sung, Patrick; HUNG-YUAN CHI Nucleic Acids Research2928
282011Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factorsHUNG-YUAN CHI ; Kwon, Young Ho; Visnapuu, Mari-Liis; Lam, Isabel; Santa Maria, Sergio R.; Zheng, Xiuzhong; Epshtein, Anastasiya; Greene, Eric C.; Sung, Patrick; Klein, Hannah L.Nucleic Acids Research1312
292010Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiaeNiu, Hengyao; Chung, Woo-Hyun; Zhu, Zhu; Kwon, Youngho; Zhao, Weixing; HUNG-YUAN CHI ; Prakash, Rohit; Seong, Changhyun; Liu, Dongqing; Lu, Lucy; Ira, Grzegorz; Sung, PatrickNature298285
302009Structural transitions within human Rad51 nucleoprotein filamentsRobertson, Ragan B.; Moses, Dana N.; Kwon, YoungHo; Chan, Pamela; HUNG-YUAN CHI ; Klein, Hannah; Sung, Patrick; Greene, Eric C.Proceedings of the National Academy of Sciences of the United States of America3835
312009Functional interactions of meiotic recombination factors Rdh54 and Dmc1HUNG-YUAN CHI ; Kwon, Youngho; Moses, Dana N.; Seong, Changhyun; Sehorn, Michael G.; Singh, Akhilesh K.; Tsubouchi, Hideo; Greene, Eric C.; Klein, Hannah L.; Sung, PatrickDNA Repair2726
322009Visualizing the Disassembly of S. cerevisiae Rad51 Nucleoprotein FilamentsRobertson, Ragan B.; Moses, Dana N.; Kwon, YoungHo; Chan, Pamela; Zhao, Weixing; HUNG-YUAN CHI ; Klein, Hannah; Sung, Patrick; Greene, Eric C.Journal of Molecular Biology1817
332008Molecular Anatomy of the Recombination Mediator Function of Saccharomyces cerevisiae Rad52Seong, Changhyun; Sehorn, Michael G.; Plate, Iben; Shi, Idina; Song, Binwei; HUNG-YUAN CHI ; Mortensen, Uffe; Sung, Patrick; Krejci, LumirJournal of Biological Chemistry4744
342008ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54Kwon, YoungHo; Seong, Changhyun; HUNG-YUAN CHI ; Greene, Eric C.; Klein, Hannah; Sung, PatrickJournal of Biological Chemistry3130
352007Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodelingYoungHo Kwon; HUNG-YUAN CHI ; Dong Hyun Roh; Hannah Klein; Patrick SungDNA Repair2019
362007Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinaseHUNG-YUAN CHI ; Joseph San Filippo; Michael G. Sehorn; Galina V. Petukhova; Patrick SungGenes and Development8984
372007A DNA-translocating Snf2 Molecular Motor: Saccharomyces cerevisiae Rdh54 Displays Processive Translocation and Extrudes DNA LoopsTekkatte Krishnamurthy Prasad; Ragan B. Robertson; Mari-Liis Visnapuu; HUNG-YUAN CHI ; Patrick Sung; Eric C. GreeneJournal of Molecular Biology6261
382007RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filamentsYiduo Hu; Steven Raynard; Michael G. Sehorn; Xincheng Lu; Wendy Bussen; Lu Zheng; Jeremy M. Stark; Ellen L. Barnes; HUNG-YUAN CHI ; Pavel Janscak; Maria Jasin; Hannes Vogel; Patrick Sung; Guangbin LuoGenes and Development261261
392006Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptideFilippo, Joseph San; HUNG-YUAN CHI ; Sehorn, Michael G.; Etchin, Julia; Krejci, Lumir; Sung, PatrickJournal of Biological Chemistry10497
402006Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase functionHUNG-YUAN CHI ; Van Komen, Stephen; Sehorn, Michael G.; Sigurdsson, Stefan; Sung, PatrickDNA Repair139134
412006Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNAHUNG-YUAN CHI ; Kwon, Youngho; Seong, Changhyun; Epshtein, Anastasiya; Lam, Isabel; Sung, Patrick; Klein, Hannah L.Journal of Biological Chemistry6256
422004Multiple interactions with the rad51 recombinase govern the homologous recombination function of Rad54Markus Raschle; Stephen Van Komen; HUNG-YUAN CHI ; Tom Ellenberger; Patrick SungJournal of Biological Chemistry5758
431998Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 proteinWei, J.C.; Lin-Shiau, S.-Y.; Boone, C.W.; Kelloff, G.J.; Lin, J.-K.; SHIN-LIAN DOONG ; HUNG-YUAN CHI Carcinogenesis2424