研究成果


第 1 到 44 筆結果，共 44 筆。

公開日期標題作者來源出版物scopusWOS全文
12023Prediction of clinically significant prostate cancer through urine metabolomic signatures: A large-scale validated studyHSIANG-PO HUANG ; CHUNG-HSIN CHEN ; Chang, Kai-Hsiung; MING-SHYUE LEE ; Lee, Cheng-Fan; Chao, Yen-Hsiang; Lu, Shih-Yu; Wu, Tzu-Fan; Liang, Sung-Tzu; Lin, Chih-Yu; Lin, Yuan Chi; SHIH-PING LIU ; YU-CHUAN LU ; CHIA-TUNG SHUN ; Huang, William J; Lin, Tzu-Ping; Ku, Ming-Hsuan; Chung, Hsiao-Jen; Chang, Yen-Hwa; Liao, Chun-Hou; Yu, Chih-Chin; Chung, Shiu-Dong; Tsai, Yao-Chou; Wu, Chia-Chang; Chen, Kuan-Chou; Ho, Chen-Hsun; Hsiao, Pei-Wen; YEONG-SHIAU PU Journal of Translational Medicine1
22023Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell GrowthCho, Chao-Cheng; Lin, Chun-Jung; Huang, Hsun-Ho; Yang, Wei-Zen; Fei, Cheng-Yin; Lin, Hsin-Ying; MING-SHYUE LEE ; Yuan, Hanna SACS chemical biology00
32022Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasisLin, Hsin-Ying; Chun-Jung Ko ; Lo, Tzu-Yu; Wu, Shang-Ru; Lan, Shao-Wei; Huang, Chen-An; Lin, Yi-Chin; Lin, Hsin-Hsien; Tu, Hsin-Fang; Lee, Cheng-Fan; Hsiao, Pei-Wen; HSIANG-PO HUANG ; MEI-JOU CHEN ; Chang, Kai-Hsiung; MING-SHYUE LEE Oncogene54
42021Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CADTu, Hsin-Fang; Chun-Jung Ko ; Lee, Ching-Tai; Lee, Cheng-Fan; Lan, Shao-Wei; Lin, Hsin-Hsien; Lin, Hsin-Ying; CHIA-CHI KU ; Lee, Der-Yen; I-CHUN CHEN ; YA-HUI CHUANG ; Del Caño-Ochoa, Francisco; Ramón-Maiques, Santiago; CHAO-CHI HO ; MING-SHYUE LEE ; GEEN-DONG CHANG Cancer research1414
52020Author Correction: The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer CellsWu, Shang-Ru; Teng, Chen-Hsin; Tu, Ya-Ting; Ko, Chun-Jung; Cheng, Tai-Shan; Lan, Shao-Wei; Lin, Hsin-Ying; Lin, Hsin-Hsien; Tu, Hsin-Fang; Hsiao, Pei-Wen; HSIANG-PO HUANG; CHUNG-HSIN CHEN ; MING-SHYUE LEE Scientific reports00
62020Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasisChun-Jung Ko ; Hsu, Ting-Wei; Wu, Shang-Ru; Lan, Shao-Wei; Hsiao, Ting-Feng; Lin, Hsin-Ying; Lin, Hsin-Hsien; Tu, Hsin-Fang; Lee, Cheng-Fan; Huang, Cheng-Chung; Chen, Mei-Ju May; Hsiao, Pei-Wen; HSIANG-PO HUANG ; MING-SHYUE LEE Oncogene2825
72019HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasisWu S.-R.; Lin C.-H.; Shih H.-P.; Chun-Jung Ko ; Lin H.-Y.; Lan S.-W.; Lin H.-H.; Tu H.-F.; CHAO-CHI HO ; HSIANG-PO HUANG ; MING-SHYUE LEE British Journal of Cancer89
82019Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptaseLee, Cheng-Fan; Dang, Andrew; Hernandez, Elizabeth; Pong, Rey-Chen; Chen, Benjamin; Sonavane, Rajni; Raj, Ganesh; Kapur, Payal; Lin, Hsin-Ying; Wu, Shang-Ru; Chun-Jung Ko ; Lo, U-Ging; HSIN-YU LEE ; Hsieh, Jer-Tsong; MING-SHYUE LEE Oncogene2729
92018Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductaseYu C.-H.; Chou C.-C.; Tu H.-F.; Huang W.-C.; Ho Y.-Y.; Khoo K.-H.; MING-SHYUE LEE ; GEEN-DONG CHANG Oncotarget110
102017The role and mechanism of epithelial-to-mesenchymal transition in prostate cancer progressionLo U.-G.; Lee C.-F.; MING-SHYUE LEE ; Hsieh J.-T.International Journal of Molecular Sciences8682
112017The Kunitz Domain i of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer CellsWu S.-R.; Teng C.-H.; Tu Y.-T.; Chun-Jung Ko ; Cheng T.-S.; Lan S.-W.; Lin H.-Y.; Lin H.-H.; Tu H.-F.; Hsiao P.-W.; HSIANG-PO HUANG ; CHUNG-HSIN CHEN ; MING-SHYUE LEE Scientific Reports1512
122017Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasisChun-Jung Ko ; Lan S.-W.; YU-CHUAN LU ; Cheng T.-S.; Lai P.-F.; Tsai C.-H.; Hsu T.-W.; Lin H.-Y.; Shyu H.-Y.; Wu S.-R.; Lin H.-H.; Hsiao P.-W.; CHUNG-HSIN CHEN ; HSIANG-PO HUANG ; MING-SHYUE LEE Oncogene3832
132016Ketamine Increases Permeability and Alters Epithelial Phenotype of Renal Distal Tubular Cells via a GSK-3β-Dependent MechanismShyu H.-Y.; Chun-Jung Ko ; Luo Y.-C.; Lin H.-Y.; Wu S.-R.; Lan S.-W.; Cheng T.-S.; Hu S.-H.; MING-SHYUE LEE Journal of Cellular Biochemistry1110
142016Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled mannerSu H.C.; Liang Y.A.; Lai Y.-J.J.; Chiu Y.-L.; Barndt R.B.; Shiao F.; Chang H.-H.D.; Lu D.D.; Huang N.; Tseng C.-C.; Wang J.-K.; MING-SHYUE LEE ; Johnson M.D.; Huang S.-M.; Lin C.-Y.PLoS ONE1110
152015N-glycan branching affects the subcellular distribution of and inhibition of matriptase by HAI-2/placental bikuninLai Y.-J.J.; Chang H.-H.D.; Lai H.; Xu Y.; Shiao F.; Huang N.; Li L.; MING-SHYUE LEE ; Johnson M.D.; Wang J.-K.; Lin C.-Y.PLoS ONE2117
162015Androgen-induced TMPRSS2 activates matriptase and promotes extracellular matrix degradation, prostate cancer cell invasion, tumor growth, and metastasisChun-Jung Ko ; Huang C.-C.; Lin H.-Y.; Juan C.-P.; Lan S.-W.; Shyu H.-Y.; Wu S.-R.; Hsiao P.-W.; HSIANG-PO HUANG ; CHIA-TUNG SHUN ; MING-SHYUE LEE Cancer Research108100
172015BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stabilityKuo P.-C.; Huang C.-W.; Lee C.-I.; Chang H.-W.; Hsieh S.-W.; Chung Y.-P.; MING-SHYUE LEE ; CHIUN-SHENG HUANG ; Tsao L.-P.; Tsao Y.-P.; SHOW-LI CHEN British Journal of Cancer1411
182014HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptaseTsai C.-H.; Teng C.-H.; Tu Y.-T.; Cheng T.-S.; Wu S.-R.; Chun-Jung Ko ; Shyu H.-Y.; Lan S.-W.; HSIANG-PO HUANG ; Tzeng S.-F.; Johnson M.D.; Lin C.-Y.; Hsiao P.-W.; MING-SHYUE LEE Oncogene4642
192013Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasisCheng T.-S.; Chen W.-C.; Lin Y.-Y.; Tsai C.-H.; Liao C.-I.; Shyu H.-Y.; Chun-Jung Ko ; Tzeng S.-F.; Huang C.-Y.; PAN-CHYR YANG ; Hsiao P.-W.; MING-SHYUE LEE Cancer Prevention Research4142
202013Lysophosphatidic acid induces reactive oxygen species generation by activating protein kinase C in PC-3 human prostate cancer cellsLin C.-C.; Lin C.-E.; Lin Y.-C.; Ju T.-K.; Huang Y.-L.; MING-SHYUE LEE ; J. H. Chen ; Lee H.Biochemical and Biophysical Research Communications2928
212012Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cellsDeng Y.-T.; Chang T.-W.; MING-SHYUE LEE ; Lin J.-K.Journal of Agricultural and Food Chemistry8672
222012Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiationHSIANG-PO HUANG ; MEI-HWEI CHANG ; Chen Y.-T.; HONG-YUAN HSU ; Chiang C.-L.; Cheng T.-S.; YAO-MING WU ; MU-ZON WU ; Hsu Y.-C.; Shen C.-C.; Lee C.-N.; YA-HUI CHUANG ; Hong C.-L.; YUNG-MING JENG ; Chen P.-H.; HUEY-LING CHEN ; MING-SHYUE LEE Hepatology1010
232011Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cellsChou F.-P.; Xu H.; MING-SHYUE LEE ; Chen Y.-W.; Richards O.X.D.; Swanson R.; Olson S.T.; Johnson M.D.; Lin C.-Y.American Journal of Physiology - Cell Physiology77
242010TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cellsChen Y.-W.; MING-SHYUE LEE ; Lucht A.; Chou F.-P.; Huang W.; Havighurst T.C.; Kim K.; Wang J.-K.; Antalis T.M.; Johnson M.D.; Lin C.-Y.American Journal of Pathology115105
252010Matriptase is involved in ErbB-2-induced prostate cancer cell invasionWu S.-R.; Cheng T.-S.; Chen W.-C.; Shyu H.-Y.; Chun-Jung Ko ; HSIANG-PO HUANG ; Teng C.-H.; Lin C.-H.; Johnson M.D.; Lin C.-Y.; MING-SHYUE LEE American Journal of Pathology3431
262009Revisiting histidine-dependent acid phosphatases: a distinct group of tyrosine phosphatasesVeeramani S.; MING-SHYUE LEE ; Lin M.-F.Trends in Biochemical Sciences1816
272009Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibitionWang J.-K.; MING-SHYUE LEE ; Tseng I.-C.; Chou F.-P.; Chen Y.-W.; Fulton A.; Lee H.-S.; Chen G.-J.; Johnson M.D.; Lin C.-Y.American Journal of Physiology - Cell Physiology6060
282008Purification from human milk of matriptase complexes with secreted serpins: Mechanism for inhibition of matriptase other than HAI-1Tseng I.-C.; Chou F.-P.; SHENG-FANG SU ; Oberst M.; Madayiputhiya N.; MING-SHYUE LEE ; Wang J.-K.; Sloane D.E.; Johnson M.; Lin C.-Y.American Journal of Physiology - Cell Physiology3936
292007Autoactivation of matriptase in vitro: Requirement for biomembrane and LDL receptor domainMING-SHYUE LEE ; Tseng I.-C.; Wang Y.; Kiyomiya K.-I.; Johnson M.D.; Dickson R.B.; Lin C.-Y.American Journal of Physiology - Cell Physiology7368
302006Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cellsKiyomiya K.-I.; MING-SHYUE LEE ; Tseng I.-C.; Zuo H.; Barndt R.J.; Johnson M.D.; Dickson R.B.; Lin C.-Y.American Journal of Physiology - Cell Physiology5351
312005HAI-1 regulates activation and expression of matriptase, a membrane-bound serine proteaseOberst M.D.; Chen L.-Y.L.; Kiyomiya K.-I.; Williams C.A.; MING-SHYUE LEE ; Johnson M.D.; Dickson R.B.; Lin C.-Y.American Journal of Physiology - Cell Physiology127118
322005Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cellsMING-SHYUE LEE ; Kiyomiya K.-I.; Benaud C.; Dickson R.B.; Lin C.-Y.American Journal of Physiology - Cell Physiology6968
332005Expression of p66Shc protein correlates with proliferation of human prostate cancer cellsVeeramani S.; Igawa T.; Yuan T.-C.; Lin F.-F.; MING-SHYUE LEE ; Lin J.S.; Johansson S.L.; Lin M.-F.Oncogene5048
342004Tyrosine-317 of p52Shc mediates androgen-stimulated proliferation signals in human prostate cancer cellsMING-SHYUE LEE ; Igawa T.; Lin M.-F.Oncogene2624
352004p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomasMING-SHYUE LEE ; Igawa T.; Chen S.-J.; Van Bemmel D.; Lin J.S.; Lin F.-F.; Johansson S.L.; Christman J.K.; Lin M.-F.International Journal of Cancer4137
362003ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cellsZelivianski S.; Spellman M.; Kellerman M.; Kakitelashvilli V.; Zhou X.-W.; Lugo E.; MING-SHYUE LEE ; Taylor R.; Davis T.L.; Hauke R.; Lin M.-F.International Journal of Cancer125124
372003ErbB-2 signaling is involved in regulating PSA secretion in androgen-independent human prostate cancer LNCaP C-81 cellsMING-SHYUE LEE ; Igawa T.; Yuan T.-C.; Zhang X.-Q.; Lin F.-F.; Lin M.-F.Oncogene5450
382002Establishment and characterization of androgen-independent human prostate cancer LNCaP cell modelIgawa T.; Lin F.-F.; MING-SHYUE LEE ; Karan D.; Batra S.K.; Lin M.-F.Prostate165157
392001Decreased expression of cellular prostatic acid phosphatase increases tumorigenicity of human prostate cancer cellsLin M.-F.; MING-SHYUE LEE ; Zhou X.-W.; Andressen J.C.; Meng T.-C.; Johansson S.L.; West W.W.; Taylor R.J.; Anderson J.R.; Lin F.-F.Journal of Urology6858
402001Characterization of a Prostate-specific Tyrosine Phosphatase by Mutagenesis and Expression in Human Prostate Cancer CellsZhang X.-Q.; MING-SHYUE LEE ; Zelivianski S.; Lin M.-F.Journal of Biological Chemistry4037
412000Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cellsMeng T.-C.; MING-SHYUE LEE ; Lin M.-F.Oncogene6457
422000Differential responsiveness of prostatic acid phosphatase and prostate-specific antigen mRNA to androgen in prostate cancer cellsLin M.-F.; MING-SHYUE LEE ; Garcia-Arenas R.; Lin F.-F.Cell Biology International2625
431996Genomic structure of carp mitogen-activated protein kinase kinase geneLeu J.-H.; MING-SHYUE LEE ; Chen K.-T.; GEEN-DONG CHANG ; Chou C.-K.; Huang C.-J.Biochimica et Biophysica Acta - Gene Structure and Expression3
441995A Protease Inhibitor of the Serpin Family Is a Major Protein in Carp Perimeningeal Fluid: II. cDNA Cloning, Sequence Analysis, and Escherichia coli ExpressionHuang, Chang-Jen; MING-SHYUE LEE ; Huang, Fore-Lien; Chang, Geen-DongJournal of Neurochemistry1617