研究成果


第 1 到 48 筆結果，共 48 筆。

公開日期標題作者來源出版物scopusWOS全文
12022Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthaseTang, Haoyu; Wu, Min-Hao; Lin, Hsiao-Yu; Han, Meng-Ru; Tu, Yueh-Hua; Yang, Zhi-Jie; Chien, Tun-Cheng; NEI-LI CHAN ; Chang, Wei-ChenProceedings of the National Academy of Sciences of the United States of America105
22022Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 HelicaseYu, Chun-Chiao; Lin, Pei-Chen; Chiang, Cho-Han; Jen, Shu-Tang; Lai, Yen-Ling; Hsu, Shih-Chin; Lo, Lee-Chiang; JING-JER LIN ; NEI-LI CHAN ; MING-JIUN YU Journal of virology22
32021Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for QuinolonesTang, Haoyu; Tang, Yijie; Kurnikov, Igor V.; Liao, Hsuan Jen; NEI-LI CHAN ; Kurnikova, Maria G.; Guo, Yisong; Chang, Wei ChenACS Catalysis98
42020Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen BondingHsieh, Chao-Ming; Chen, Chun-Yi; JI-WANG CHERN ; NEI-LI CHAN Journal of medicinal chemistry96
52020Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl IntermediateLi, Jikun; Liao, Hsuan-Jen; Tang, Yijie; Huang, Jhih-Liang; Cha, Lide; Lin, Te-Sheng; Lee, Justin L; Kurnikov, Igor V; Kurnikova, Maria G; Chang, Wei-Chen; NEI-LI CHAN ; Guo, YisongJournal of the American Chemical Society4037
62019Hypoxia-induced Slug SUMOylation enhances lung cancer metastasisHung P.-F.; Hong, T.-M.; Chang C.-C.; Hung C.-L.; Hsu Y.-L.; YIH-LEONG CHANG ; CHEN-TU WU ; Chang G.-C.; NEI-LI CHAN ; SUNG-LIANG YU ; PAN-CHYR YANG ; SZU-HUA PAN Journal of Experimental and Clinical Cancer Research2019
72018Structural insights into the gating of DNA passage by the topoisomerase II DNA-gateChen S.-F.; Huang N.-L.; Lin J.-H.; Wu C.-C.; Wang Y.-R.; Yu Y.-J.; Gilson M.K.; NEI-LI CHAN Nature Communications3736
82018Topoisomerases as anticancer targetsDelgado J.L.; Hsieh C.-M.; NEI-LI CHAN ; Hiasa H.Biochemical Journal264252
92018Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism ElucidationLiao H.-J.; Li J.; Huang J.-L.; Davidson M.; Kurnikov I.; Lin T.-S.; Lee J.L.; Kurnikova M.; Guo Y.; NEI-LI CHAN ; Chang W.-C.Angewandte Chemie - International Edition3834
102017Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegansYeh, H.-Y.; Lin, S.-W.; Wu, Y.-C. ; NEI-LI CHAN ; P. Chi Scientific Reports44
112017Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistryWang Y.-R.; Chen S.-F.; Wu C.-C.; Liao Y.-W.; Lin T.-S.; Liu K.-T.; Chen Y.-S.; TSAI-KUN LI ; Chien T.-C.; NEI-LI CHAN Nucleic Acids Research6060
122016Strong inhibition of betanodavirus replication by ribavirin targeting RNA-dependent RNA polymeraseHuang Y.-C.; Lin T.-S.; Peng C.; NEI-LI CHAN ; YU-SAN HAN Journal of Fish Diseases1211
132016SMYD3-mediated H2A.Z.1 methylation promotes cell cycle and cancer proliferationTsai C.-H.; Chen Y.-J.; Hung J.-J.; SHIOU-RU TZENG ; Chen W.-Y.; WEN-HUNG KUO ; Lin M.-C.; NEI-LI CHAN ; Chen Y.-J.; Cheng W.-C.; SHU-CHUN TENG ; Wu K.-J.Cancer Research4241
142016Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase ActivityLee Y.-R.; Lin T.-S.; Lai S.-J.; Liu M.-S.; Lai M.-C.; NEI-LI CHAN Scientific Reports33
152016Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced DegradationChen, Yi-Hsuan; Hsu, Hua-Yi; Yeh, Ming-Tyng; Chen, Chen-Cheng; Huang, Chang-Yu; Chung, Ying-Hsuan; ZEE-FEN CHANG ; WEI-CHEN KUO; NEI-LI CHAN ; Weng, Jui-Hsia; Chung, Bon-Chu; Chen, Y.-J.; Jian, Cheng-Bang; Shen, Ching-Chieh; Tai, H.-C. ; Sheu, Sheh-Yi; Fang, J.-M. Journal of Medicinal Chemistry1312
162015Structural basis of antizyme-mediated regulation of polyamine homeostasisWu H.-Y.; Chen S.-F.; Hsieh J.-Y.; Chou F.; Wang Y.-H.; Lin W.-T.; Lee P.-Y.; Yu Y.-J.; Lin L.-Y.; Lin T.-S.; Lin C.-L.; Liu G.-Y.; SHIOU-RU TZENG ; Hung H.-C.; NEI-LI CHAN Proceedings of the National Academy of Sciences of the United States of America5553
172015Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopyMartinez-Farina C.F.; McCormick N.; Robertson A.W.; Clement H.; Jee A.; Ampaw A.; NEI-LI CHAN ; Syvitski R.T.; Jakeman D.L.Organic and Biomolecular Chemistry1410
182015Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerRChang C.-C.; Lin L.-Y.; Zou X.-W.; Huang C.-C.; NEI-LI CHAN Nucleic Acids Research5351
192014Structural characteristics of the nonallosteric human cytosolic malic enzymeHsieh J.-Y.; Li S.-Y.; Chen M.-C.; Yang P.-C.; Chen H.-Y.; NEI-LI CHAN ; Liu J.-H.; Hung H.-C.Biochimica et Biophysica Acta - Proteins and Proteomics1616
202013New insights into DNA-binding by type IIA topoisomerasesChang C.-C.; Wang Y.-R.; Chen S.-F.; Wu C.-C.; NEI-LI CHAN Current Opinion in Structural Biology2118
212013New mechanistic and functional insights into DNA topoisomerasesChen S.H.; NEI-LI CHAN ; Hsieh T.-S.Annual Review of Biochemistry256248
222013DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lambliaLin B.-C.; Su L.-H.; Weng S.-C.; Pan Y.-J.; NEI-LI CHAN ; TSAI-KUN LI ; Wang H.-C.; CHIN-HUNG SUN PLoS Neglected Tropical Diseases119
232013On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugsWu C.-C.; Li Y.-C.; Wang Y.-R.; TSAI-KUN LI ; NEI-LI CHAN Nucleic Acids Research137134
242012Expression, purification, crystallization and preliminary X-ray analysis of the RecQ helicase catalytic core from Deinococcus radioduransChen S.-C.; Huang C.-H.; Yang C.-S.; Chang C.-H.; Kuan S.-M.; NEI-LI CHAN ; Chen Y.Acta Crystallographica Section F: Structural Biology and Crystallization Communications11
252012Expression, purification, crystallization and preliminary X-ray analysis of ribitol-5-phosphate cytidylyltransferase from Bacillus subtilisChen S.-C.; Yang C.S.; Lin C.-T.; NEI-LI CHAN ; Chang M.-C.; Chen Y.Acta Crystallographica Section F: Structural Biology and Crystallization Communications11
262012Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profilesLee C.-H.; Hsieh M.-Y.; LING-WEI HSIN ; Chen H.-C.; Lo S.-C.; Fan J.-R.; Chen W.-R.; Chen H.-W.; NEI-LI CHAN ; TSAI-KUN LI Biochemical Pharmacology1212
272011The many blades of the β-propeller proteins: Conserved but versatileChen C.K.-M.; NEI-LI CHAN ; Wang A.H.-J.Trends in Biochemical Sciences130127
282011Structural basis of type II topoisomerase inhibition by the anticancer drug etoposideWu C.-C.; TSAI-KUN LI ; Farh L.; Lin L.-Y.; Lin T.-S.; Yu Y.-J.; Yen T.-J.; Chiang C.-W.; NEI-LI CHAN Science388380
292010In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformationPan R.-Y.; Hung T.-M.; Kou Y.-H.; NEI-LI CHAN ; MING-FU CHANG ; SHIN CHANG FEBS Letters65
302010Twisting of the DNA-binding surface by a β-strand-bearing proline modulates DNA gyrase activityHsieh T.-J.; Yen T.-J.; Lin T.-S.; Chang H.-T.; Huang S.-Y.; Hsu C.-H.; Farh L.; NEI-LI CHAN Nucleic Acids Research2623
312008Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation changeLi Y.-C.; Chiang C.-W.; Yeh H.-C.; Hsu P.-Y.; Whitby F.G.; Wang L.-H.; NEI-LI CHAN Journal of Biological Chemistry4641
322007The crystal structure of XC1258 from Xanthomonas campestris: A putative procaryotic Nit protein with an arsenic adduct in the active siteChin K.-H.; Tsai Y.-D.; NEI-LI CHAN ; Huang K.-F.; Wang A.H.-J.; Chou S.-H.Proteins: Structure, Function and Genetics1111
332007Mutation of a key residue in the type II secretion system ATPase uncouples ATP hydrolysis from protein translocationShiue S.-J.; Chien I.-L.; NEI-LI CHAN ; Leu W.-M.; Hu N.-T.Molecular Microbiology44
342006原核生物IIA型DNA拓撲異構酶辨認受質幾何構形機制之探討NEI-LI CHAN ; Tung-Ju Hsieh; Lynn Farh化學00
352006高效能大分子結晶學相位解析技術之發展現況NEI-LI CHAN ; Chia-Wang Chiang; Yi-Ching Li; Li-Ying Lin; Tung-Ju Hsieh科儀新知00
362006Crystal Structure of the Human Prostacyclin SynthaseChiang C.-W.; Yeh H.-C.; Wang L.-H.; NEI-LI CHAN Journal of Molecular Biology5650
372006XpsE oligomerization triggered by ATP binding, not hydrolysis, leads to its association with XpsLShiue S.-J.; Kao K.-M.; Leu W.-M.; Chen L.-Y.; NEI-LI CHAN ; Hu N.-T.EMBO Journal4444
382006Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundlesLin L.-Y.; Ching C.-L.; Chin K.-H.; Chou S.-H.; NEI-LI CHAN Proteins: Structure, Function and Genetics77
392005Asymmetrical synthesis of L-Homophenylalanine using engineered Escherichia coli aspartate aminotransferaseLo H.-H.; Hsu S.-K.; Lin W.-D.; NEI-LI CHAN ; Hsu W.-H.Biotechnology Progress3027
402005Structure and function of the XpsE N-terminal domain, an essential component of the Xanthomonas campestris type II secretion systemChen Y.; Shiue S.-J.; Huang C.-W.; Chang J.-L.; Chien Y.-L.; Hu N.-T.; NEI-LI CHAN Journal of Biological Chemistry3232
412004蛋白質結構及其生技應用NEI-LI CHAN 生物科技產學論壇00
422004Structure of the topoisomerase IV C-terminal domain: A broken β-propeller implies a role as geometry facilitator in catalysisHsieh T.-J.; Farh L.; Huang W.M.; NEI-LI CHAN Journal of Biological Chemistry4342
432004Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of ParC protein from Bacillus stearothermophilusHsieh T.-J.; NEI-LI CHAN Acta Crystallographica Section D: Biological Crystallography44
442004Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human HemoglobinNEI-LI CHAN ; Kavanaugh J.S.; Rogers P.H.; Arnone A.Biochemistry79
452004Crystallization and preliminary X-ray crystallographic analysis of the N-terminal domain of XpsE protein from Xanthomonas campestris, an essential component of the type II protein-secretion machineryChen Y.; Hu N.-T.; NEI-LI CHAN Acta Crystallographica Section D: Biological Crystallography11
462001Defining polyubiquitin chain topologyNEI-LI CHAN ; Hill C.P.Nature Structural Biology2222
472000Cys-93-ββ-succinimidophenyl polyethylene glycol 2000 hemoglobin A: Intramolecular cross-bridging of hemoglobin outside the central cavityManjula B.N.; Malavallin A.; Smith P.K.; NEI-LI CHAN ; Arnone A.; Friedman J.M.; Acharya A.S.Journal of Biological Chemistry3634
481998Crystal structure of the S-nitroso form of liganded human hemoglobinNEI-LI CHAN ; Rogers P.H.; Arnone A.Biochemistry106107