研究成果


第 1 到 14 筆結果，共 14 筆。

公開日期標題作者來源出版物scopusWOS全文
12024Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancerWang, Kang-Li; Yeh, Tsung-Yu; Hsu, Pei-Chen; Wong, Tzu-Hsuan; Liu, Jia-Rong; JI-WANG CHERN ; Lin, Miao-Hsia; CHAO-WU YU Journal of enzyme inhibition and medicinal chemistry
22024J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and micePan, Zhijian; Shao, Min; Zhao, Chen; Yang, Xuanjun; Li, Haitao; Cui, Guozhen; Liang, Xiaonan; CHAO-WU YU ; Ye, Qingqing; Gao, Cheng; Di, Lijun; JI-WANG CHERN ; Zhou, Hefeng; Lee, Simon Ming-YuenEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
32024A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancerYe, Pei-Chen; Leu, Wohn-Jenn; Yeh, Tsung-Yu; Hsu, Yu-Tung; Lin, Yi-Chin; Wei, Zi-Yuan; Chen, Yi-Chin; Chiang, Yi-Chang; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; JI-WANG CHERN ; CHAO-WU YU ; JIH-HWA GUH The Prostate
42023Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasomePan, Zhijian; CHAO-WU YU ; Zhao, Chen; Shao, Min; Yang, Xuanjun; Liang, Xiaonan; Li, Haitao; Lu, Yucong; Ye, Qingqing; JI-WANG CHERN ; Lu, Jiahong; Zhou, Hefeng; Lee, Simon Ming-YuenToxicology and applied pharmacology
52023Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary FibrosisYu, Wei-Chieh; Yeh, Tsung-Yu; Ye, Chih-Hung; Chong, Patrick Chun Theng; Ho, Yi-Hsun; So, Dorothy Kazuno; Yap, Kah Yi; Peng, Guan-Ru; Shao, Chi-Hsuan; Jagtap, Ajit Dhananjay; JI-WANG CHERN ; CHEN-SI LIN ; Lin, Shau-Ping; SHUEI-LIONG LIN ; SHU-HAN YU ; CHAO-WU YU Journal of medicinal chemistry4
62021Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavityPeng, Cheng; Li, Yu-Hsuan; CHAO-WU YU ; Cheng, Ze-Hua; Liu, Jia-Rong; Hsu, Jui-Ling; LING-WEI HSIN ; Huang, Chen-Tsung; HSUEH-FEN JUAN ; JI-WANG CHERN ; YI-SHENG CHENG Bioorganic Chemistry32
72019High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastomaLiu, J.-R.; CHAO-WU YU ; Hung, P.-Y.; LING-WEI HSIN ; JE-RUEI LIU Biochemical Pharmacology5748
82019Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung CancerCHAO-WU YU ; Hung P.-Y.; Yang H.-T.; Ho Y.-H.; Lai H.-Y.; Cheng Y.-S. ; Chern J.-W.Journal of Medicinal Chemistry3836
92018Novel histone deacetylase inhibitors and embryo aggregation enhance cloned embryo development and ES cell derivation in pigsSiriboon C.; Li T.-S.; CHAO-WU YU ; Chern J.-W.; Ju J.-C.PLoS ONE32
102018A highly HDAC6-selective inhibitor acts as a fluorescent probeHo, Yi-Hsun; Wang, Kuang-Jui; Hung, Pei-Yun; Cheng, Yi-Sheng ; Liu, Jia-Rong; Fung, Sheang-Tze; PI-HUI LIANG ; JI-WANG CHERN ; CHAO-WU YU Organic and Biomolecular Chemistry19
112015A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowthChang P.-T.; Talekar R.S.; FAN-LU KUNG ; Chern T.-R.; Huang C.-W.; Ye Q.-Q.; Yang M.-Y.; CHAO-WU YU ; Lai S.-Y.; Deore R.R.; Lin J.-H.; Chen C.-S.; Chen G.S.; Chern J.-W.Neuropharmacology99
122013Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's diseaseCHAO-WU YU ; Chang P.-T.; LING-WEI HSIN ; Chern J.-W.Journal of Medicinal Chemistry9082
132012Efficient microwave-assisted Pd-catalyzed hydroxylation of aryl chlorides in the presence of carbonateCHAO-WU YU ; Chen G.S.; Huang C.-W.; Chern J.-W.Organic Letters6559
142010Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitorsKhanwelkar, Rahul R.; Chen, Grace Shiahuy; Wang, Hsiao-Chun; Yu, Chao-Wu ; Huang, Chiung-Hua; Lee, On; Chen, Chih-Hung; Hwang, Chrong-Shiong; Ko, Ching-Huai; Chou, Nien-Tzu; Lin, Mai-Wei; Wang, Ling-mei; Chen, Yen-Chun; Hseu, Tzong-Hsiung; Chang, Chia-Ni; Hsu, Hui-Chun; Lin, Hui-Chi; Shih, Ying-Chu; Chou, Shuen-Hsiang; Tseng, Hsiang-Wen; Liu, Chih-Peng; Tu, Chia-Mu; Hu, Tsan-Lin; Tsai, Yuan-Jang; Chern, Ji-WangBIOORGANIC & MEDICINAL CHEMISTRY2728