DC Field | Value | Language |
dc.contributor.author | 黃耀輝 | zh-TW |
dc.date | 2001-07-31 | zh_TW |
dc.date.accessioned | 2006-07-25T07:55:07Z | en |
dc.date.accessioned | 2018-06-29T17:20:55Z | - |
dc.date.available | 2006-07-25T07:55:07Z | en |
dc.date.available | 2018-06-29T17:20:55Z | - |
dc.date.issued | 2001-07-31 | - |
dc.identifier | 892314B002375 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/4942 | - |
dc.description.abstract | 半導體晶圓製造過程中,維修工程師
在拆卸機台進行保修作業時有可能暴露到
危害物質,特別是作業環境中的砷或砷化
物。本研究以高效能液相層析儀結合原子
吸收光譜儀進行維修工程師的尿中砷代謝
物種分析,以瞭解其維修作業中可能的砷
暴露。共有30 名來自六家不同晶圓廠的維
修工程師被列為暴露組,另每家晶圓廠兩
名工業衛生師共12 人組成對照組。於機台
維修當週,針對暴露組與對照組的研究對
象連續七天採集每日早起第一泡尿液樣
本。尿中三價砷、五價砷、單甲基砷酸、
二甲基砷酸及總無機砷代謝物平均濃度分
別為1.7±1.4 ug/L, 1.4±1.1 ug/L, 6.2±6.7
ug/L, 20.2±14.1 ug/L, 29.5±17.2 ug/L 。單甲
基砷酸及其佔尿中總無機砷代謝濃度百分
比在對照組、無保養作業的維修工程師及
有保樣作業的維修工程師之間分別呈現遞
增趨勢(p<0.005 及 p<0.0005)。本研究也指
出低濃度砷暴露情況下,尿中總無機砷代
謝濃度可能會受食物中砷醣的干擾而誤導
無機砷暴露量的測量。然而在此情況下,
以尿中砷物種分析觀察單甲基砷酸比例的
變化是一項適當有用的指標,足以確定暴
露的存在。 | zh_TW |
dc.description.abstract | For the wafer fabrication in
semiconductor industry, the maintenance
engineers are potentially exposed to hazards
during their work of disassembling machine
compartments for clean-up. One special
concern is arsenic or arsenic compounds in
working environment. The present study
analyzed speciated urinary inorganic arsenic
metabolites of the maintenance engineers
with HPLC-HG-AAS to study the potential
arsenic exposure during their maintenance
work. Totally, from 6 wafer fabrication
facilities, 30 maintenance engineers were
recruited as exposed group, so were the
another 12 office-based industrial hygienists
serving as control group. First morning
voided urine samples of each study subject
were collected for 7 consecutive days.
Results show the levels of total urinary
inorganic arsenic metabolites for exposed
group were 1.7±1.4 ug/L, 1.4±1.1 ug/L,
6.2±6.7 ug/L, 20.2±14.1 ug/L, 29.5±17.2
ug/L for As 3+ , As 5+ , monomethylarsonic acid,
dimethylarsinic acid and total inorganic
arsenic, respectively. Both concentration of
monomethylarsonic acid and its proportion
among various urinary inorganic arsenic
metabolites showed significantly ascending
trend among control group, engineers without
preventative maintenance work prior to their
urine sampling, and those with such work
prior to sampling (p<0.005, and p<0.0005,
respectively). It was aslo suggested that, at
low level occupational arsenic exposure, the
concentration of total urinary inorganic
arsenic metabolites might be misleading due
to the confounding effect of arsenosuger
coming from seafood. Nevertheless,
speciation of urinary arsenic species is good
and appropriate in such case to use the
proportion change of monomethylarsonic
acid as an indicator for the verification of arsenic exposure. | en |
dc.format | application/pdf | en |
dc.format.extent | 135410 bytes | en |
dc.format.mimetype | application/pdf | en |
dc.language | zh-TW | - |
dc.language.iso | zh_TW | zh_TW |
dc.publisher | 臺北市:國立臺灣大學公共衛生學院職業醫學與工業衛生研究所 | zh_TW |
dc.rights | 國立臺灣大學公共衛生學院職業醫學與工業衛生研究所 | zh_TW |
dc.subject | 砷 | zh_TW |
dc.subject | 尿 | zh_TW |
dc.subject | 物種分離 | zh_TW |
dc.subject | 離子植入 | zh_TW |
dc.subject | 保養維修 | zh_TW |
dc.subject | Arsenic | en |
dc.subject | Urine | en |
dc.subject | Speciation | en |
dc.subject | Ion
Implanter | en |
dc.subject | Preventative Maintenance | en |
dc.title | 晶圓廠離子植入機台維修人員尿中砷物種分析 | zh_TW |
dc.title.alternative | Speciation of Urinary Arsenic of the Ion Implanter
Maintenance Engineers in the Semiconductor
Fabircation Facility | en |
dc.type | report | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/4942/1/892314B002375.pdf | - |
dc.coverage | 計畫年度:89
第二期;起迄日期:2000-08-01/2001-07-31 | zh_TW |
item.openairetype | report | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_93fc | - |
item.fulltext | with fulltext | - |
item.languageiso639-1 | zh_TW | - |
item.grantfulltext | open | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0003-1817-8969 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
Appears in Collections: | 環境與職業健康科學研究所
|