https://scholars.lib.ntu.edu.tw/handle/123456789/111190
標題: | 1.先生的飲酒行為是產後婦女生活品質的危險因子.應用極致液相層析/串聯式質譜儀分析人體血漿中之全氟碳化合物 – 初步研究 1.Husbands’ drinking behavior as a risk factor of wives’ health-related quality of life in the postpartum period.Determination of perfluorinated compounds in human plasma using ultra performance liquid chromatography–tandem mass spectrometry – preliminary study |
作者: | 吳禮堯 Wu, Li-Yao |
關鍵字: | 健康相關的生活品質;先生的飲酒行為;產後婦女;全氟碳化合物;極致液相層析/質譜/質譜儀;全氟辛烷磺酸;全氟辛酸;血漿;health-related quality of life;husbands’ drinking behavior;postpartum women;Perfluorinated compounds;PFOS;PFOA;UPLC/MS/MS;Plasma | 公開日期: | 2009 | 摘要: | 1. ABTRACTurpose: The objective of this study is to investigate the association between husbands’ alcohol drinking and wives’ HRQOL in the postpartum period.ethods: We used multistage stratified systematic sampling to recruit 24,200 pairs, postpartum women and newborns, from the Taiwan national birth register in 2005. A structured questionnaire was successfully administered to 87.8% of the sampled population. Subjects undertook a home interview 6 months after their deliveries between June 2005 and July 2006. The Medical Outcomes Study 36-item Short-Form (SF-36) was used to measure the quality of life of the women with their husbands’ alcohol drinking behavior.esults: After controlling for the potential confounders, there were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning along with the increase in frequency of husbands’ alcohol drinking. There were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning and role-physical along with the increase in frequency of husbands’ alcohol drinking either in primiparous or multiparous womenonclusions: Our study adds evidence supporting the adverse effect of husbands’ alcohol drinking on women’s health as measured by the SF-36 HRQOL. . ABTRACTurpose: The aim of this study was to develop a sensitive, convenient and accurate method by using UPLC-MS/MS for a broad range of PFCs for studies involving large sample series. ethods: We analyze the perfluorinated compounds by using ultra performance liquid chromatography-tandem mass spectrometry with protein precipitation and matrix-matched calibration method. And seven samples of plasma from TBPS were analyzed to investigate the applicability of this validated method.esults: Perfluorinated compounds were detected in all seven plasma samples. The average concentration of PFOS and PFOA were 31.25 ng/mL and 3.52 ng/mL. Moreover, UPLC provides significantly reduced analysis time and improved chromatographic behavior for PFCs compared with traditional LC.onclusions: The low sample volume needed, the limited time consuming and the broad range of analytes which are included, make this method advantageous for large-scale epidemiological studies. Besides, this sample preparation technique and matrix-matched calibration method can easily be set up on standard LC-MS/MSnstruments and is thus available to a wide range of laboratories. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/182405 |
顯示於: | 環境與職業健康科學研究所 |
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ntu-98-R96841010-1.pdf | 23.32 kB | Adobe PDF | 檢視/開啟 |
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