https://scholars.lib.ntu.edu.tw/handle/123456789/111268
標題: | ASSOCIATION OF HEPATITIS VIRUS INFECTION, ALCOHOL CONSUMPTION AND PLASMA VITAMIN A LEVELS WITH URINARY 8-HYDROXYDEOXYGUANOSINE IN CHEMICAL WORKERS | 作者: | WONG, RUEY-HONG YEH, CHING-YING HSUEH, YU-MEI WANG, JUNG-DER LEI, YU-CHEN CHENG, TSUN-JEN |
關鍵字: | OXIDATIVE DNA-DAMAGE;VINYL-CHLORIDE;BETA-CAROTENE;HEPATOCYTES;RETINOL;SMOKING | 公開日期: | 2003 | 卷: | v.535 | 期: | n.2 | 起(迄)頁: | 181-186 | 來源出版物: | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 摘要: | Urinary 8-hydroxydeoxyguanosine (8-OHdG) DNA adduct has been used as a biomarker in epidemiological studies. However , the determinants for urinary 8-OHdG have not been clearly identified. We tested urinary 8-OHdG levels in 205 male workers who had been exposed to vinyl chloride monomer (VCM) . Epidemiological information was obtained by an interviewer -administered questionnaire. Hepatitis B surface antigen ( HBsAg) and anti-hepatitis C antibody (anti-HCV) were also determined by immunoassay. Plasma antioxidants including Vitamins A and E, alpha- and beta-carotenes were assayed by high performance liquid chromatography. Median of urinary 8- OHdG level was 9.8 ng/mg creatinine (range, 1.4- 60.1). Multiple linear regression analysis showed that alcohol drinkers had higher urinary 8-OHdG than those who did not, but there was no dose-response between the amount of alcohol consumption and urinary 8-OHdG. Workers with positive HBsAg , anti-HCV and elevated plasma Vitamin A level were independently associated with higher levels of urinary 8- OHdG, whereas age, smoking, body mass index, plasma alpha- and beta-carotenes, Vitamin E levels, or VCM exposure did not show such an association. The results suggest that active inflammation of hepatitis B and C, alcohol consumption and higher Vitamin A level can induce oxidative stress. Thus, we conclude that potential determinants need to be considered in epidemiological studies when urinary 8- OHdG is used as a biomarker. (C) 2002 Elsevier Science B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/80263 |
顯示於: | 環境與職業健康科學研究所 |
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