https://scholars.lib.ntu.edu.tw/handle/123456789/111268
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 職業醫學與工業衛生研究所;Institute of Occupational Medicine and Industrial Hygiene | en |
dc.contributor.author | WONG, RUEY-HONG | en |
dc.contributor.author | YEH, CHING-YING | en |
dc.contributor.author | HSUEH, YU-MEI | en |
dc.contributor.author | WANG, JUNG-DER | en |
dc.contributor.author | LEI, YU-CHEN | en |
dc.contributor.author | CHENG, TSUN-JEN | en |
dc.creator | WONG, RUEY-HONG;YEH, CHING-YING;HSUEH, YU-MEI;WANG, JUNG-DER;LEI, YU-CHEN;CHENG, TSUN-JEN | en |
dc.creator | 翁瑞宏;葉錦瑩;薛玉梅;王榮德;雷侑蓁;鄭尊仁 | zh-tw |
dc.date | 2003 | en |
dc.date.accessioned | 2008-07-10T03:24:58Z | - |
dc.date.accessioned | 2018-06-29T17:27:19Z | - |
dc.date.available | 2008-07-10T03:24:58Z | - |
dc.date.available | 2018-06-29T17:27:19Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/80263 | - |
dc.description.abstract | Urinary 8-hydroxydeoxyguanosine (8-OHdG) DNA adduct has been used as a biomarker in epidemiological studies. However , the determinants for urinary 8-OHdG have not been clearly identified. We tested urinary 8-OHdG levels in 205 male workers who had been exposed to vinyl chloride monomer (VCM) . Epidemiological information was obtained by an interviewer -administered questionnaire. Hepatitis B surface antigen ( HBsAg) and anti-hepatitis C antibody (anti-HCV) were also determined by immunoassay. Plasma antioxidants including Vitamins A and E, alpha- and beta-carotenes were assayed by high performance liquid chromatography. Median of urinary 8- OHdG level was 9.8 ng/mg creatinine (range, 1.4- 60.1). Multiple linear regression analysis showed that alcohol drinkers had higher urinary 8-OHdG than those who did not, but there was no dose-response between the amount of alcohol consumption and urinary 8-OHdG. Workers with positive HBsAg , anti-HCV and elevated plasma Vitamin A level were independently associated with higher levels of urinary 8- OHdG, whereas age, smoking, body mass index, plasma alpha- and beta-carotenes, Vitamin E levels, or VCM exposure did not show such an association. The results suggest that active inflammation of hepatitis B and C, alcohol consumption and higher Vitamin A level can induce oxidative stress. Thus, we conclude that potential determinants need to be considered in epidemiological studies when urinary 8- OHdG is used as a biomarker. (C) 2002 Elsevier Science B.V. All rights reserved. | en |
dc.format | application/ | en |
dc.language | en-us | en |
dc.language | en-US | en |
dc.language.iso | en_US | - |
dc.relation | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS v.535 n.2 pp.181-186 | en |
dc.relation.ispartof | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | - |
dc.subject | OXIDATIVE DNA-DAMAGE | en |
dc.subject | VINYL-CHLORIDE | en |
dc.subject | BETA-CAROTENE | en |
dc.subject | HEPATOCYTES | en |
dc.subject | RETINOL | en |
dc.subject | SMOKING | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | ASSOCIATION OF HEPATITIS VIRUS INFECTION, ALCOHOL CONSUMPTION AND PLASMA VITAMIN A LEVELS WITH URINARY 8-HYDROXYDEOXYGUANOSINE IN CHEMICAL WORKERS | en |
dc.type | journal article | en |
dc.relation.pages | 181-186 | - |
dc.relation.journalvolume | v.535 | - |
dc.relation.journalissue | n.2 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/80263/1/36.pdf | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | open | - |
顯示於: | 環境與職業健康科學研究所 |
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