https://scholars.lib.ntu.edu.tw/handle/123456789/111318
標題: | INCREASED LYMPHOCYTE SISTER CHROMATID EXCHANGE FREQUENCY IN WORKERS WITH EXPOSURE TO LOW LEVEL OF ETHYLENE DICHLORIDE | 作者: | CHENG, TSUN-JEN | 關鍵字: | sister chromatid exchange;smoking;vinyl chloride;ethylene dichloride | 公開日期: | 2000 | 卷: | 470 | 期: | 2 | 起(迄)頁: | 109-114 | 來源出版物: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 摘要: | The genotoxicity of low-level exposure to ethylene dichloride (EDC) and vinyl chloride monomer (VCM) in humans is not clear. We used lymphocyte sister chromatid exchange ( SCE) frequency as a parameter to investigate the genotoxicity of low level EDC and VCM in VCM-manufacturing workers. The SCE frequency was determined for 51 male workers with exposure to VCM and/or EDC and for 20 male workers devoid of such exposure. Epidemiological data were obtained by questionnaire, and included history of smoking, drinking, and any medication taken, as well as a detailed occupational history. Personal- and area-sampling and analysis were conducted in order to calculate the time- weighted average (TWA) contaminant-exposure level corresponding to different job categories. Moderate EDC exposure around 1 ppm corresponded to a significantly greater SCE frequency than was the case for the low EDC exposure group (p<0.01). However, VCM exposure of similar level was not associated with increased SCE. We conclude that EDC may cause genotoxicity at a relatively low level of exposure. (C) 2000 Elsevier Science B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/83465 |
顯示於: | 環境與職業健康科學研究所 |
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