https://scholars.lib.ntu.edu.tw/handle/123456789/111845
標題: | Reduced Expression of C/Ebp Alpha Protein in Hepatocellular Carcinoma Is Associated with Advanced Tumor Stage and Shortened Patient Survival | 作者: | TSENG, HSI-HUANG HWANG, YAW-HUEI |
關鍵字: | CCAAT/enhancer binding protein alpha;Immunohistochemistry;Hepatocellular carcinoma;Survival | 公開日期: | 2009 | 卷: | v.135 | 期: | n.2 | 起(迄)頁: | 241-247 | 來源出版物: | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 摘要: | CCAAT/enhancer binding protein alpha (C/EBP alpha) is a transcription factor and a tumor suppressor. We aimed to assess its protein expression and prognostic value in human hepatocellular carcinoma (HCC). We conducted a retrospective cohort study on 50 HCC patients and performed immunohistochemistry against C/EBP alpha on tumors and adjacent nontumor specimens. Relationships of C/EBP alpha expression with clinical parameters and patient survival were analyzed. C/EBP alpha expression was not influenced by chronic alcohol exposure, viral hepatitis, or cirrhosis, but was reduced in 60% of HCC. Reduction of C/EBP alpha was associated with advanced tumor stage (P = 0.001). Patients with markedly reduced C/ EBP alpha expression had a significantly shorter survival with a hazard ratio of 5.45 ( 95% confidence interval, 1.93-15.40; P = 0.001). C/EBP alpha may be a potential prognostic marker or therapeutic target in HCC regardless of different etiology. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/235890 |
顯示於: | 環境與職業健康科學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。