https://scholars.lib.ntu.edu.tw/handle/123456789/111898
標題: | Simultaneous Analysis of Chlorpyrifos and Cypermethrin in Cord Blood Plasma by Online Solid-Phase Extraction Coupled with Liquid Chromatography -Heated Electrospray Ionization Tandem Mass Spectrometry | 作者: | HSIEH, CHIA-JUNG CHIANG, SU-YIN LIN, MING-HUAN CHEN, PAU-CHUNG �d�O�� |
關鍵字: | Pesticide;Chlorpyrifos;Cypermethrin;Organophosphate;Pyrethroid;Cord blood;Online SPE;LC/MS/MS | 公開日期: | 2011 | 卷: | v.879 | 期: | n.21 | 起(迄)頁: | 1961-1966 | 來源出版物: | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 摘要: | Chlorpyrifos and cypermethrin are the most used insecticides in Taiwan. Exposure to both pesticides has been associated with reproductive and developmental health effects in humans and animals. This study describes an online solid-phase extraction coupled with liquid chromatography-heated electrospray ionization tandem mass spectrometry (online SPE -LC/HESI/MS/ MS) method to analyze chlorpyrifos and cypermethrin in cord blood of pregnant women. Calibration curves showed good linearity (r(2) > 0.998) for both pesticides within the range of 0.1-100 ppb. Limits of detection ( LODs) were 0.01 and 0.05 ppb and recoveries in cord blood were 97.2 +/- 4. 8% and 93.5 +/- 9.5% for chlorpyrifos and cypermethrin respectively. After analysis of 396 samples, the mean concentrations of chlorpyrifos and cypermethrin were 0.38 and 1.08 ppb respectively. These results demonstrate that LC/HESI/MS/MS is effective for the simultaneous analysis of chlorpyrifos and cypermethrin in cord blood with excellent sensitivity and specificity and may also be effective for high throughput assay in future epidemiology studies. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/240401 |
顯示於: | 環境與職業健康科學研究所 |
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