https://scholars.lib.ntu.edu.tw/handle/123456789/112199
標題: | Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan | 作者: | Chen, Chien-Jen Hsu, Lin-I Wang, Chih-Hao Shih, Wei-Liang |
關鍵字: | Arsenic;Health hazards;Taiwan;Biomarkers | 公開日期: | 15-十月-2004 | 起(迄)頁: | 198-206 | 來源出版物: | Toxicology & Applied Pharmacology 206 | 摘要: | Long-term exposure to inorganic arsenic from drinking water has been documented to induce cancers & vascular diseases in a doseresponse relationship. A series of molecular environmental epidemiological studies have been carried out to elucidate biomarkers of exposure, effect, & susceptibility for arsenic-related health hazards in Taiwan. Arsenic levels in urine, hair, & nail are biomarkers for short-term (b1 year) internal dose, skin hyperpigmentation & palmoplantar hyperkeratosis are for long-term (many years) internal dose, & percentage of monomethylarsonic acid in total metabolites of inorganic arsenic in urine may be considered as an exposure marker for biologically effective dose. The biomarkers of early biological effects of ingested inorganic arsenic included blood levels of reactive oxidants & anti-oxidant capacity, genetic expression of inflammatory molecules, as well as cytogenetic changes including sister chromatid exchange, micronuclei, & chromosome aberrations of peripheral lymphocyes. Both mutation type & hot spots of p53 gene were significantly different in arsenic-induced & non-arsenic-induced TCCs. The frequency of chromosomal imbalances analyzed by comparative genomic hybridization & the frequency of loss of heterozygosity were significantly higher in arsenic-induced TCC than non-arsenic-induced TCC at specific sites. Biomarkers of susceptibility to arsenic-induced health hazards included genetic polymorphisms of enzymes involved in xenobiotic metabolism, DNA repair, & oxidative stress, as well as serum level of carotenoids. Gene–gene & gene–environment interactions are involved in arsenic-induced health hazards through toxicological mechanisms including genomic instability & oxidative stress. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/2006111501275569 | 其他識別: | 246246/2006111501275569 |
顯示於: | 流行病學與預防醫學研究所 |
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