https://scholars.lib.ntu.edu.tw/handle/123456789/112206
標題: | MIXTURE MULTI-STATE MARKOV REGRESSION MODEL | 作者: | YEN, AMY, MING-FANG CHEN, TONY, HSIU-HIS 陳秀熙 |
關鍵字: | Markov mixture model;multi-state;model selection | 公開日期: | 2007 | 卷: | v.34 | 期: | n.1 | 起(迄)頁: | 11-21 | 來源出版物: | JOURNAL OF APPLIED STATISTICS | 摘要: | Although heterogeneity across individuals may be reduced when a two-state process is extended into a multi-state process, the discrepancy between the observed and the predicted for some states may still exist owing to two possibilities, unobserved mixture distribution in the initial state and the effect of measured covariates on subsequent multi-state disease progression. In the present study, we developed a mixture Markov exponential regression model to take account of the above-mentioned heterogeneity across individuals (subject-to-subject variability) with a systematic model selection based on the likelihood ratio test. The model was successfully demonstrated by an empirical example on surveillance of patients with small hepatocellular carcinoma treated by non-surgical methods. The estimated results suggested that the model with the incorporation of unobserved mixture distribution behaves better than the one without. Complete and partial effects regarding risk factors on different subsequent multistate transitions were identified using a homogeneous Markov model . The combination of both initial mixture distribution and homogeneous Markov exponential regression model makes a significant contribution to reducing heterogeneity across individuals and over time for disease progression. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81422 |
顯示於: | 流行病學與預防醫學研究所 |
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