https://scholars.lib.ntu.edu.tw/handle/123456789/112209
Title: | TYPE 2 DIABETES AND HEPATOCELLULAR CARCINOMA: A COHORT STUDY IN HIGH PREVALENCE AREA OF HEPATITIS VIRUS INFECTION | Authors: | LAI, MEI-SHU HSIEH, MENG-SHU CHIU, YUEH-HSIA CHEN, TONY, HSIU-HIS 陳秀熙 |
Keywords: | PRIMARY LIVER-CANCER;RISK-FACTORS;GROWTH-FACTORS;MELLITUS;TAIWAN;POPULATION | Issue Date: | 2006 | Journal Volume: | v.43 | Journal Issue: | n.6 | Start page/Pages: | 1295-1302 | Source: | HEPATOLOGY | Abstract: | This study aimed to elucidate the relationship of type 2 diabetes, other known risk factors, and primary hepatocellular carcinoma (HCC) in countries with a high prevalence of hepatitis infection. We followed a prospective cohort of 54,979 subjects who participated in the Keelung Community-Based Integrated Screening program between 1999 and 2002. A total of 5,732 subjects with type 2 diabetes cases were identified at enrollment on the basis of fasting blood glucose level, and a total of 138 confirmed HCC cases were identified either through two-stage liver cancer screening or linkage with the National Cancer Registry. The independent effect of type 2 diabetes on the incidence of HCC and the interaction between type 2 diabetes and hepatitis infection or lipids profile were assessed using the Cox proportional hazards regression model. After controlling for age, sex, hepatitis B virus (HBV), hepatitis C virus (HCV), smoking, and alcohol consumption, the association between type 2 diabetes and incidence of HCC ( excluding 33 prevalent cases identified at enrollment) was modified by HCV status and cholesterol level. The associations were only statistically significant (adjusted hazard ratio [HR] = 2.08 [1-03-4.18]) for being HCV negative and for having hypercholesterolemia (adjusted HR = 2.81 [1. 20-6-55]). These statistically significant findings remained even excluding cases of diabetes newly diagnosed at enrollment. In conclusion, in an area with a high prevalence of hepatitis virus infection, type 2 diabetes increases the risk of developing HCC in those who are HCV negative or have a high level of total cholesterol. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81432 |
Appears in Collections: | 流行病學與預防醫學研究所 |
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