https://scholars.lib.ntu.edu.tw/handle/123456789/112209
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 預防醫學研究所;Institute of Preventive Medicine | en |
dc.contributor.author | LAI, MEI-SHU | en |
dc.contributor.author | HSIEH, MENG-SHU | en |
dc.contributor.author | CHIU, YUEH-HSIA | en |
dc.contributor.author | CHEN, TONY, HSIU-HIS | en |
dc.contributor.author | 陳秀熙 | zh_TW |
dc.creator | LAI, MEI-SHU;HSIEH, MENG-SHU;CHIU, YUEH-HSIA;CHEN, TONY, HSIU-HIS | en |
dc.creator | 賴美淑;謝孟書;邱月暇;陳秀熙 | zh_TW |
dc.date | 2006 | en |
dc.date.accessioned | 2008-08-20T02:45:46Z | - |
dc.date.accessioned | 2018-06-29T17:49:30Z | - |
dc.date.available | 2008-08-20T02:45:46Z | - |
dc.date.available | 2018-06-29T17:49:30Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/81432 | - |
dc.description.abstract | This study aimed to elucidate the relationship of type 2 diabetes, other known risk factors, and primary hepatocellular carcinoma (HCC) in countries with a high prevalence of hepatitis infection. We followed a prospective cohort of 54,979 subjects who participated in the Keelung Community-Based Integrated Screening program between 1999 and 2002. A total of 5,732 subjects with type 2 diabetes cases were identified at enrollment on the basis of fasting blood glucose level, and a total of 138 confirmed HCC cases were identified either through two-stage liver cancer screening or linkage with the National Cancer Registry. The independent effect of type 2 diabetes on the incidence of HCC and the interaction between type 2 diabetes and hepatitis infection or lipids profile were assessed using the Cox proportional hazards regression model. After controlling for age, sex, hepatitis B virus (HBV), hepatitis C virus (HCV), smoking, and alcohol consumption, the association between type 2 diabetes and incidence of HCC ( excluding 33 prevalent cases identified at enrollment) was modified by HCV status and cholesterol level. The associations were only statistically significant (adjusted hazard ratio [HR] = 2.08 [1-03-4.18]) for being HCV negative and for having hypercholesterolemia (adjusted HR = 2.81 [1. 20-6-55]). These statistically significant findings remained even excluding cases of diabetes newly diagnosed at enrollment. In conclusion, in an area with a high prevalence of hepatitis virus infection, type 2 diabetes increases the risk of developing HCC in those who are HCV negative or have a high level of total cholesterol. | en |
dc.language | en_us | en |
dc.language.iso | en_US | - |
dc.relation | HEPATOLOGY v.43 n.6 pp.1295-1302 | en |
dc.relation.ispartof | HEPATOLOGY | - |
dc.subject | PRIMARY LIVER-CANCER | en |
dc.subject | RISK-FACTORS | en |
dc.subject | GROWTH-FACTORS | en |
dc.subject | MELLITUS | en |
dc.subject | TAIWAN | en |
dc.subject | POPULATION | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | TYPE 2 DIABETES AND HEPATOCELLULAR CARCINOMA: A COHORT STUDY IN HIGH PREVALENCE AREA OF HEPATITIS VIRUS INFECTION | en |
dc.type | journal article | en |
dc.relation.pages | 1295-1302 | - |
dc.relation.journalvolume | v.43 | - |
dc.relation.journalissue | n.6 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
顯示於: | 流行病學與預防醫學研究所 |
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