https://scholars.lib.ntu.edu.tw/handle/123456789/112256
標題: | CONSISTENCY OF GENETIC INHERITANCE MODE AND HERITABILITY PATTERNS OF TRIGLYCERIDE VS. HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO IN TWO TAIWANESE FAMILY SAMPLES | 作者: | CHIEN, KUO-LIONG | 關鍵字: | APOLIPOPROTEIN-A-I;CORONARY HEART-DISEASE;PLASMA HDL- CHOLESTEROL;CLINICS PROGRAM FAMILY;SEGREGATION ANALYSIS;QUANTITATIVE-TRAIT | 公開日期: | 2003 | 卷: | v.4 | 期: | n.1 | 起(迄)頁: | p-7 | 來源出版物: | BMC GENETICS | 摘要: | Background: Triglyceride/HDL cholesterol ratio (TG/HDL-C)is considered as a risk factor for cardiovascular events. Genetic components were important in controlling the variation in western countries. But the mode of inheritance and family aggregation patterns were still unknown among Asian-Pacific countries. This study, based on families recruited from community and hospital, is aimed to investigate the mode of inheritance, heritability and shared environmental factors in controlling TG/HDL-C. Results: Two populations, one from community-based families (n = 988, 894 parent-offspring and 453 sibling pairs) and the other from hospital-based families ( n = 1313, 76 parent-offspring and 52 sibling pairs) were sampled. The population in hospital-based families had higher mean age values than community-based families (54.7 vs. 34.0). Logarithmic transformed TG/HDL-C values, after adjusted by age, gender and body mass index, were for genetic analyses. Significant parent-offspring and sibling correlations were also found in both samples. The parent-offspring correlation coefficient was higher in the hospital-based families than in the community-based families. Genetic heritability was higher in community-based families (0.338 +/- 0.114, p = 0.002), but the common shared environmental factor was higher in hospital-based families (0.203 +/- 0.042, p < 0.001). Commingling analyses showed that more than one-component distribution models were the best-fit models to explain the variance in both populations. Complex segregation analysis by regressive models revealed that in both samples the best- fit model of TG/HDL-C was the model of environmental effects plus familial correlation, in which significant parent- offspring and sibling correlations were demonstrated . Models of major gene effects were rejected in both samples . Conclusion: Variations of TG/HDL-C in the normal ranges were likely to be influenced by multiple factors, including environmental and genetic components. Higher genetic factors were proved in younger community-based families than in older hospital-based families. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81661 |
顯示於: | 流行病學與預防醫學研究所 |
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