https://scholars.lib.ntu.edu.tw/handle/123456789/112487
標題: | APPLICATION OF GENETIC POLYMORPHISMS IN DNA REPAIR IN THE PREDICTION OF CANCER SUSCEPTIBILITY AND CLINICAL OUTCOME | 作者: | CHEN, CHIEN-JEN | 關鍵字: | DNA repair;polymorphisms;cancer risk;treatment | 公開日期: | 2003 | 卷: | v.1 | 期: | n.3 | 起(迄)頁: | 175-186 | 來源出版物: | CURRENT PHARMACOGENOMICS | 摘要: | The capacity to repair damaged DNA is a basic tool by which the mammalian cell maintains its genetic integrity and prevents neoplasm; however, DNA repair function could be modified by genetic polymorphisms. Recent molecular epidemiological studies have indicated that these genetic variants occur in the normal population and can be used to predict individual cancer risk. Since variation in the function of these genes might impact a cancer cell's viability or resistance to treatment, genetic variants in DNA repair might act as a valuable marker in forecasting the results of cancer treatment. This possibility has been outlined by some clinical pilot studies of genetic polymorphisms in the DNA repair genes. With the biological importance of the DNA repair genes, studies of these genetic variants occurring in the general population will further our understanding of cancer etiology and behavior. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81970 |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。