https://scholars.lib.ntu.edu.tw/handle/123456789/112686
標題: | PREVALENCE AND MANIFESTATIONS OF HEPATITIS C SEROPOSITIVITY IN CHILDREN IN AN ENDEMIC AREA | 作者: | LU, SHENG-NAN CHEN, HUI-CHI WU, MEI-HUEI YU, MING-LUNG CHUANG, WAN-LONG LU, CHIH-FENG CHANG, WEN-YU CHEN, CHIEN-JEN |
關鍵字: | hepatitis C virus;epidemiology;children | 公開日期: | 1998 | 卷: | v.17 | 期: | n.2 | 起(迄)頁: | 142-145 | 來源出版物: | PEDIATRIC INFECTIOUS DISEASE JOURNAL | 摘要: | Background. According to our previous studies, Paisha Township in Penghu Islets is an endemic area for hepatitis B virus and hepatitis C virus (HCV) infection and for hepatocellular carcinoma. We conducted this study to understand the prevalence: of anti-HCV seropositivity among children in this area and to observe clinical manifestations of anti-HCV-positive children, Methods. In March, 1994, 1164 (93.6%) of 1243 students from all 6 kindergartens, 9 primary schools and 3 middle schools in Paisha Township participated in the screening for anti-HCV by enzyme immunoassay with second generation commercial kits (Abbott EIA 2.0). Anti-HCV tests were duplicated for the positive sera in 2 laboratories. All anti-HCV-positive children were followed annually for 2 years. Results. The prevalences of children from kindergartens (ages 3 to 6 years), primary schools (ages 7 to 12 years) and middle schools (ages 13 to 15 years) were 0% (0 of 229), 0.8% (5 of 617) and 1.9% (6 of 318), respectively. Initially the optic density (OD) values of anti-HCV were >2.0 in 4 cases (36%), between 1.0 and 2.0 in 2 cases, and <1.0 in the other 5 cases, None had sonographic parenchymal changes in the liver. In the 2-year follow-up of the anti-HCV-positive subjects, type 2a HCV-RNA persisted in 3 of 4 children with an OD of anti-HCV more than 2.0; 2 of them had 2 elevations of alanine transaminase values. Four of 7 children with an OD of 2.0 or less had a decrease in OD values in the follow-up examinations, and 2 of them became anti-HCV-negative. Conclusion. Only 36% (4 of 11) of anti-HCV-positive children had an OD of >2.0. Subjects with sequentially low OD might recover from chronic HCV infection without detectable HCV RNA and with normal alanine aminotransferase values. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/83461 |
顯示於: | 流行病學與預防醫學研究所 |
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