https://scholars.lib.ntu.edu.tw/handle/123456789/112710
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 流行病學所 | en |
dc.contributor.author | Hung, Chin-Chuan | en |
dc.contributor.author | Tai, John Jen | en |
dc.contributor.author | Kao, Pi-Ju | en |
dc.contributor.author | Lin, Min-Shung | en |
dc.contributor.author | Liou, Horng-Huei | en |
dc.creator | Hung, Chin-Chuan; Tai, John Jen; Kao, Pi-Ju; Lin, Min-Shung; Liou, Horng-Huei | en |
dc.creator | 洪靚娟;戴政;劉宏輝 | zh-tw |
dc.date | 2007 | en |
dc.date.accessioned | 2008-10-20T05:53:29Z | - |
dc.date.accessioned | 2018-06-29T18:00:13Z | - |
dc.date.available | 2008-10-20T05:53:29Z | - |
dc.date.available | 2018-06-29T18:00:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/83969 | - |
dc.description.abstract | Objectives: The aim of this study was to investigate whether the polymorphisms in the NR112 and ABCB1 genes were associated with epilepsy treatment responses. Methods & results: NR112 and ABCB1 polymorphisms were genotyped in 114 drug-resistant epileptic patients, 213 seizure-free patients and 287 normal controls. Highly specific real-time PCR was applied to detect the variants by using TaqMan allelic specific probe. For a single gene test, it was demonstrated that 3435C>T in the ABCB1 gene had a significant effect on epilepsy treatment responses, but polymorphisms in the NR112 gene did not. Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification. In the present study, the polymorphisms in the NR112 gene were not significantly associated with epilepsy treatment responses. Conclusion: Our results indicated that 2677G>T and 3435C > T in the ABCB1 gene contributed to drug-resistant epilepsy. Although biologically plausible, the polymorphisms in NR112 investigated in the present study did not play a role in epilepsy treatment responses. Other unveiled genetic variants in the NR112 gene that may have the potential to affect ABCB1 gene expression are worth further investigation in future studies. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | PHARMACOGENOMICS v.8 n.9 pp.1151-1158 | en |
dc.relation.ispartof | PHARMACOGENOMICS | - |
dc.subject | ABCB1 | en |
dc.subject | drug | en |
dc.subject | response | en |
dc.subject | intractable epilepsy | en |
dc.subject | multidrug resistance | en |
dc.subject | pharmacogenetics | en |
dc.subject | PXR | en |
dc.title | ASSOCIATION OF POLYMORPHISMS IN NR1I 2 AND ABCB1 GENES WITH EPILEPSY TREATMENT RESPONSES | en |
dc.type | journal article | en |
dc.relation.pages | 1151-1158 | - |
dc.relation.journalvolume | v.8 | - |
dc.relation.journalissue | n.9 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
顯示於: | 流行病學與預防醫學研究所 |
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