https://scholars.lib.ntu.edu.tw/handle/123456789/113405
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 流行病學所 | en |
dc.contributor.author | WANG, RUEY-YUN | en |
dc.contributor.author | CHEN, CHIEN-CHUNG et al. | en |
dc.creator | Wang, Ruey-Yun; Chung, Chia-Min; Fann, Cathy Sheng-Jiuan; Yang, Hsin-Chou; Chen, Jaw-Wen; Jong, Yuh-Shium; Jou, Yuh-Shan; Lo, Huey-Ming; Ho, Feng-Ming; Kang, Chih-Sen; Chen, Chien-Chung; Chang, Huan-Cheng; Shyue, Song-Kun; Pan, Wen-Harn | - |
dc.date | 2008 | en |
dc.date.accessioned | 2009-11-24T03:07:38Z | - |
dc.date.accessioned | 2018-06-29T18:17:15Z | - |
dc.date.available | 2009-11-24T03:07:38Z | - |
dc.date.available | 2018-06-29T18:17:15Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/173144 | - |
dc.description.abstract | Objectives: Angiotensin converting enzyme ( ACE) plays major roles in the pathogenesis of cardiovascular diseases ( CVD) . However, findings on the relations between ACE variants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci ( QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases ( estimated heritability = 0.58). Methods: With 1, 271 individuals from 373 young- onset ( age <= 40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM ( LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM ( LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | HUMAN HEREDITY v.65 n.2 pp.85-90 | en |
dc.relation.ispartof | Human Heredity | en_US |
dc.subject | genome-wide scan | en |
dc.subject | hypertension | en |
dc.subject | angiotensin converting enzyme | en |
dc.subject | quantitative trait loci | en |
dc.subject | Chinese | en |
dc.subject | Taiwan | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | dipeptidyl carboxypeptidase; adult; article; cardiovascular disease; chromosome 17q; chromosome 9; enzyme activity; enzyme regulation; female; gene identification; genome; genotype; human; hypertension; major clinical study; male; pedigree; phenotype; quantitative trait locus; Age of Onset; Cardiovascular Diseases; Female; Genome, Human; Genotype; Humans; Hypertension; Linkage Disequilibrium; Male; Pedigree; Peptidyl-Dipeptidase A; Phenotype; Taiwan | - |
dc.title | Genome-Wide Scan for Quantitative Ace Activity in Taiwan Young-Onset Hypertension Study | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1159/000108940 | - |
dc.identifier.isi | WOS:000250096600004 | - |
dc.relation.pages | 85-90 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Center for Artificial Intelligence and Advanced Robotics | - |
crisitem.author.orcid | 0000-0002-3848-0180 | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
顯示於: | 流行病學與預防醫學研究所 |
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