https://scholars.lib.ntu.edu.tw/handle/123456789/113426
標題: | Serum Uric Acid Level as an Independent Risk Factor for All-Cause, Cardiovascular, and Ischemic Stroke Mortality: A Chinese Cohort Study | 作者: | CHUANG, SHAO-YUAN CHEN, HSIN-JEN YEH, WEN-TING PAN, WEN-HARN |
公開日期: | 2009 | 起(迄)頁: | 225-232 | 來源出版物: | Arthritis & Rheumatism | 摘要: | Objective. The association between hyperuricemia and cardiovascular events has been documented in high-risk groups, hot is still undetermined in general populations, especially Chinese, This study assessed the temporal association between serum uric acid level, hyperuricemia, and cardiovascular mortality. Methods. A prospective cohort study of 41,879 men and 48,514 women ages >= 35 years was conducted using data from the MJ Health Screening Centers in Taiwan. Mortality from all causes, total cardiovascular disease (CVD), ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels. Results. A total of 1,151 (21.2%) events of 5,427 total deaths were ascribed to CVD (mean followup 8.2 years ). Hazard ratios (HRs) for hyperuricemia (serum uric acid level > 7 mg/dl) were estimated with Cox regression model after adjusting for age, sex, body mass index, cholesterol, triglycerides, diabetes, hypertension, heavy cigarette smoking, and frequent alcohol consumption. In all patients, HRs were 1.16 (P < 0.001) for all-cause mortality, 1,39 (P < 0.001) for total CVD, and 1.35 (P = 0.02) for ischemic stroke. In subgroup analysis, the HRs for cardiovascular risk remained significant in patients with hypertension (1. 44, P < 0.001) and in patients with diabetes (1.64, P < 0 . 001). In addition, in a low metabolic risk subgroup, the HRs for all- cause mortality and total cardiovascular morbidity were 1.24 (P = 0.02) and 1.48 (P = 0.16), respectively. Conclusion, Hyperuricemia was an independent risk factor of mortality from all causes, total CVD, and ischemic stroke in the Taiwanese general population, in high-risk groups, and potentially in low-risk groups. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/185261 | DOI: | 10.1002/art.24164 | SDG/關鍵字: | cholesterol; triacylglycerol; uric acid; adult; alcohol consumption; article; body mass; cardiovascular disease; cardiovascular risk; cerebrovascular accident; Chinese; cholesterol blood level; cigarette smoking; clinical trial; cohort analysis; congestive heart failure; controlled clinical trial; controlled study; diabetes mellitus; disease association; female; high risk population; human; hypertension; hyperuricemia; ischemic heart disease; major clinical study; male; morbidity; mortality; prospective study; risk assessment; triacylglycerol blood level; uric acid blood level; Adult; Cardiovascular Diseases; Female; Humans; Hyperuricemia; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Taiwan; Uric Acid |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。