https://scholars.lib.ntu.edu.tw/handle/123456789/113830
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 流行病學與預防醫學研究所 | en |
dc.contributor.author | CHEN, JIN-DE | en_US |
dc.contributor.author | YANG, HWAI-I | en_US |
dc.contributor.author | YOU, SAN-LIN | en_US |
dc.contributor.author | LU, SHENG-NAN | en_US |
dc.contributor.author | WANG, LI-YU | en_US |
dc.contributor.author | SUN, CHIEN-AN | en_US |
dc.contributor.author | LIAW, YUN-FAN | en_US |
dc.contributor.author | CHEN, CHIEN-JEN | en_US |
dc.contributor.author | Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBV (REVEAL-HBV) Study Group | en_US |
dc.contributor.author | (CHYI-FENG JAN) | en_US |
dc.creator | 陳錦得;楊懷壹;游山林;盧勝男;王豊裕;孫建安;廖運範;陳建仁 | zh-tw |
dc.creator | CHEN, JIN-DE;YANG, HWAI-I;YOU, SAN-LIN;LU, SHENG-NAN;WANG, LI-YU;SUN, CHIEN-AN;LIAW, YUN-FAN;CHEN, CHIEN-JEN | en |
dc.date | 2010 | en |
dc.date.accessioned | 2011-06-24T06:35:21Z | - |
dc.date.accessioned | 2018-06-29T18:27:04Z | - |
dc.date.available | 2011-06-24T06:35:21Z | - |
dc.date.available | 2018-06-29T18:27:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/235786 | - |
dc.description.abstract | BACKGROUND & AIMS: The risk and the predictors of liver disease progression in carriers of inactive hepatitis B virus (HBV) are unclear. METHODS: Participants in the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) study who were seronegative for hepatitis B e antigen; had serum levels of HBV DNA < 10,000 copies/mL; and did not have cirrhosis, hepatocellular carcinoma, or increased serum levels of alanine aminotransferase were classified as carriers of inactive HBV (n = 1932). Study participants who were seronegative for HB surface antigen and antibodies against hepatitis C virus, yet had similar clinical liver features, were the controls (n = 18, 137). Liver-related death and new cases of hepatocellular carcinoma were ascertained through computerized data linkage with National Cancer Registry and Death Certification profiles. The disease progression rates were estimated. The multivariate-adjusted hazard ratios for risk predictors were derived from Cox regression models. RESULTS: There were 20 ,069 participants, contributing a total of 262,122 person-years, with a mean follow-up of 13.1 years. Annual incidence rates of hepatocellular carcinoma and liver-related death were 0.06% and 0.04%, respectively, for inactive HBV carriers; rates were 0.02%, and 0.02% for controls, respectively. The multivariate-adjusted hazard ratios for carriers of inactive HBV, compared to controls, were 4.6 (95% confidence interval: 2.5 -8.3) for hepatocellular carcinoma and 2.1 (95% confidence interval: 1 .1- 4.1) for liver-related death. Older age and alcohol drinking habits were independent predictors of risk for carriers of inactive HBV to develop hepatocellular carcinoma . CONCLUSIONS: Carriers of inactive HBV have a substantial risk of hepatocellular carcinoma and liver-related death compared with individuals not infected with HBV. | en_US |
dc.language | en-us | en |
dc.language.iso | en_US | en_US |
dc.relation | GASTROENTEROLOGY v.138 n.5 pp.1747-1754 | en_US |
dc.relation.ispartof | Gastroenterology | en_US |
dc.subject | Inactive HBV Carrier | en_US |
dc.subject | Hepatocellular Carcinoma | en_US |
dc.subject | Liver-Related Death | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; hepatitis B(e) antigen; virus DNA; adult; age distribution; alanine aminotransferase blood level; alcohol consumption; article; cancer growth; cancer incidence; cancer risk; cause of death; controlled study; disease activity; female; hepatitis B; human; liver cell carcinoma; liver disease; major clinical study; male; mortality; priority journal; virus carcinogenesis; virus carrier | - |
dc.title | Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1053/j.gastro.2010.01.042 | - |
dc.relation.pages | 1747-1754.e1 | en_US |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Referral Management Center | - |
crisitem.author.orcid | 0000-0003-2893-2187 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 流行病學與預防醫學研究所 |
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