https://scholars.lib.ntu.edu.tw/handle/123456789/114084
Title: | Contributions of diabetic macro-vascular complications and hip fracture to depression onset in elderly patients with diabetes: An 8-year population-based follow-up study | Authors: | Pan, Hsueh-Hsing Li, Chung-Yi Chen, Pei-Chun Lee, Ming-Der Liang, Chun-Yu Hou, Wen-Hsuan Wang, Kwua-Yun |
Keywords: | Depression;Diabetic complications;Elderly;Population-based | Issue Date: | 2012 | Start page/Pages: | 180-184 | Source: | Journal of Psychosomatic Research | Abstract: | Objective: To prospectively examine the roles of diabetic macro-vascular complications and hip fracture in association with depression onset in Taiwan's elderly diabetic population. Methods: A representative sample of elderly diabetic patients (n=144,216) identified in 2000 were linked to National Health Insurance claims (2000-2007) to ascertain the diagnoses of depression in both outpatient and inpatient settings. The person-year approach with Poisson assumption was used to estimate the hazard rates. Using Cox proportional hazard regression model, we evaluated the relative risk of depression in relation to diabetic macro-vascular complications and hip fracture. The additive effects from the above medical conditions were also assessed. Results: The 8-year cumulative risk of depression was 5.08%, representing an incidence density of 8.40 per 1000 patient-years. Hazard ratio (HR) with 95% confidence interval (Cl) for the elderly diabetes associated with cardiovascular disease (CVD), hip fracture, and lower extremity amputation was 1.13 (1.04-1.23), 1.10(0.91-1.34), and 1.25 (0.95-1.65), respectively. Additionally, we found that the more the complications or hip fracture, the higher the risk of depression onset in elderly diabetes. Conclusion: The increased number of diabetic macro-vascular complications and hip fracture is significantly associated with a higher risk of depression onset in elderly diabetes. Future studies should be conducted to assess the feasibility and cost-effectiveness of intensive depression screening program in elderly diabetes suffering from macro-vascular complications and hip fracture. (C) 2012 Elsevier Inc. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/259987 | DOI: | 10.1016/j.jpsychores.2012.06.003 | SDG/Keyword: | aged; article; cohort analysis; depression; diabetic angiopathy; disease association; female; follow up; hazard ratio; hip fracture; human; incidence; major clinical study; male; non insulin dependent diabetes mellitus; population research; prospective study; risk assessment; risk factor; Age Factors; Aged; Cardiovascular Diseases; Depressive Disorder; Diabetic Angiopathies; Female; Follow-Up Studies; Hip Fractures; Humans; Male; Poisson Distribution; Proportional Hazards Models; Prospective Studies; Risk; Sex Factors; Taiwan |
Appears in Collections: | 流行病學與預防醫學研究所 |
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