|dc.creator||Pan, Hsueh-Hsing;Li, Chung-Yi;Chen, Pei-Chun;Lee, Ming-Der;Liang, Chun-Yu;Hou, Wen-Hsuan;Wang, Kwua-Yun||en|
|dc.description.abstract||Objective: To prospectively examine the roles of diabetic macro-vascular complications and hip fracture in association with depression onset in Taiwan's elderly diabetic population. Methods: A representative sample of elderly diabetic patients (n=144,216) identified in 2000 were linked to National Health Insurance claims (2000-2007) to ascertain the diagnoses of depression in both outpatient and inpatient settings. The person-year approach with Poisson assumption was used to estimate the hazard rates. Using Cox proportional hazard regression model, we evaluated the relative risk of depression in relation to diabetic macro-vascular complications and hip fracture. The additive effects from the above medical conditions were also assessed. Results: The 8-year cumulative risk of depression was 5.08%, representing an incidence density of 8.40 per 1000 patient-years. Hazard ratio (HR) with 95% confidence interval (Cl) for the elderly diabetes associated with cardiovascular disease (CVD), hip fracture, and lower extremity amputation was 1.13 (1.04-1.23), 1.10(0.91-1.34), and 1.25 (0.95-1.65), respectively. Additionally, we found that the more the complications or hip fracture, the higher the risk of depression onset in elderly diabetes. Conclusion: The increased number of diabetic macro-vascular complications and hip fracture is significantly associated with a higher risk of depression onset in elderly diabetes. Future studies should be conducted to assess the feasibility and cost-effectiveness of intensive depression screening program in elderly diabetes suffering from macro-vascular complications and hip fracture. (C) 2012 Elsevier Inc. All rights reserved.||en|
|dc.relation||J. Psychosomat. Res., 73(3), 180-184||en|
|dc.relation.ispartof||Journal of Psychosomatic Research||-|
|dc.title||Contributions of diabetic macro-vascular complications and hip fracture to depression onset in elderly patients with diabetes: An 8-year population-based follow-up study||en|
|Appears in Collections:||流行病學與預防醫學研究所|
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