https://scholars.lib.ntu.edu.tw/handle/123456789/114572
Title: | AN AIRBORNE MOLD-DERIVED PRODUCT, BETA-1,3-D-GLUCAN, POTENTIATES AIRWAY ALLERGIC RESPONSES | Authors: | WAN, GWO-HWA LI, CHIH-SHAN GUO, SHIU-PING RYLANDER, RAGNAR LIN, RONG-HWA |
Keywords: | Allergy;Airway inflammation;Glucan;Asthma;Animal model | Issue Date: | 1999 | Journal Volume: | v.29 | Start page/Pages: | 2491-2497 | Source: | EUROPEAN JOURNAL OF IMMUNOLOGY | Abstract: | Repeated inhalation of allergen leads to the downregulation of allergen-specific IgE responses in non-atopic individuals as well as in mice. This phenomenon is named as inhalation- induced IgE tolerance. In contrast, inhaled allergen causes significant IgE and allergic responses in atopic persons. The mechanisms involved in this differential regulation of airway allergen-specific immune responses remain unclear. Besides the allergen exposure in genetic susceptible individuals, environmental contaminant is considered to play as an initiating factor for airway allergic responses. By using murine model, we demonstrate here that airborne b-1,3- glucan, which exists frequently in our environments particularly in highly humid area, can abrogate inhalation- induced IgE isotype-specific down- regulation and promote airway eosinophil infiltration to inhaled antigen. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/81773 |
Appears in Collections: | 環境與職業健康科學研究所 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.