https://scholars.lib.ntu.edu.tw/handle/123456789/114595
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 環境衛生研究所;Institute of Environmental Health | en |
dc.contributor.author | LU, CHUNG-YEN | en |
dc.contributor.author | MA, YEE-CHUNG | en |
dc.contributor.author | LIN, JIA-MING | en |
dc.contributor.author | CHUANG, CHUN-YU | en |
dc.contributor.author | SUNG, FUNG-CHANG | en |
dc.creator | LU, CHUNG-YEN;MA, YEE-CHUNG;LIN, JIA-MING;CHUANG, CHUN-YU;SUNG, FUNG-CHANG | en |
dc.creator | 呂宗烟;馬一中;林嘉明;莊淳宇;宋鴻樟 | zh-tw |
dc.date | 2007 | en |
dc.date.accessioned | 2008-09-15T06:50:20Z | - |
dc.date.accessioned | 2018-06-30T01:25:45Z | - |
dc.date.available | 2008-09-15T06:50:20Z | - |
dc.date.available | 2018-06-30T01:25:45Z | - |
dc.date.issued | 2007 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/81798 | - |
dc.description.abstract | This study investigated whether urinary 8 - hydroxydeoxyguano sine (8-OHdG), a biomarker of oxidative stress, was associated with indoor air quality for non- smokers in high- rise building offices. With informed consents, urine samples from 344 non-smoking employees in 86 offices were: collected to determine 8-OHdG concentrations. The concentrations of carbon dioxide (CO2) and total volatile organic compounds (TVOCs) in each office and outside of the building were simultaneously measured for eight office hours . The average workday difference between indoor and outdoor CO2 concentrations (dCO(2)) was used as a surrogate measure of the ventilation efficiency for each office unit. The CO2 levels in the offices ranged 467-2810 ppm with a mean of 1170 ppm, or 2.7 times higher than that in the outside air. The average urinary 8-OHdG levels among employees increased from 3. 10 mu g/g creatinine, for those at the lowest tertile levels of both dCO(2) and TVOCs, to 6. 27 mu g/g creatinine, for those at the highest tertile levels. Multivariate logistic regression analysis showed that the risk of having the urinary 8-OHdG level of greater than the median, 4.53 mu g/g creatinine, for participants was increased significantly at the highest tertile dCO(2) level of > 680 ppm (odds ratio (OR) = 3.37, 95% confidence interval (CI) = 1.20-9.46). The effect was significant at the middle tertile TVOCs level of 114-360 ppb (OR = 2.62, 95 % Cl = 1.43-4.79) , but not at the highest tertile. Inadequate ventilation in office increases the risk of building-related oxidative stress in non-smoking employees. (c) 2006 Elsevier Inc. All rights reserved. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | ENVIRONMENTAL RESEARCH v.103 n.3 pp.331-337 | en |
dc.relation.ispartof | ENVIRONMENTAL RESEARCH | - |
dc.subject | oxidative stress | en |
dc.subject | 8-hydroxydeoxyguanosine | en |
dc.subject | carbon dioxide | en |
dc.subject | volatile organic compounds | en |
dc.subject | ventilation rate | en |
dc.subject | high-rise building office | en |
dc.title | OXIDATIVE DNA DAMAGE ESTIMATED BY URINARY 8-HYDROXYDEOXYGUANOSINE AND INDOOR AIR POLLUTION AMONG NON- SMOKING OFFICE EMPLOYEES | en |
dc.type | journal article | en |
dc.relation.pages | 331-337 | - |
dc.relation.journalvolume | v.103 | - |
dc.relation.journalissue | n.3 | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
顯示於: | 環境與職業健康科學研究所 |
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