Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 電機資訊學院
  3. 光電工程學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/120561
Title: 生物醫學光電造影技術研究
Study on Optical Imaging Techniques for Biomedical Applications
Authors: 王義閔
Wang, Yih-Ming
Keywords: 遮罩方式;光學同調斷層掃描;高膽固醇肝;gating method;optical coherence tomography;hypercholesterolemic liver
Issue Date: 2009
Abstract: 
對於臨床診斷而言,生物醫學影像系統的進展是一個非常重要的課題,而且生物組織的光學特性至今仍有許多不為人知需要進一步探討的領域。在本研究論文中,我們利用時間、孔徑以及角度遮罩(gating)等方式對假體、雞胸肉以及雞肝組織的穿透訊號加以分析比較,進而發現這三種方法所收集的光子有所不同,但是對於影像品質的提升都有所幫助。因此不同的組織結構應該都有其適合的遮罩方式來提升其影像的品質。所以對不同的生物組織結構尋找適合的遮罩方式是相當值得研究的議題。學同調斷層掃描(Optical coherence tomography, OCT)目前已廣泛應用在許多疾病的診斷上。但在許多狀況下,組織病理上的變化非常的細微,例如像是光學散射特性的變化非常細微以致於非常難以量測得到。因此對於臨床應用上,提升影像對比變得更為重要。其中偏振敏感式光學同調斷層掃描(Polarization-sensitive optical coherence tomography, PSOCT)也就是結合光學同調斷層掃描的解析度並藉由控制光的偏振得以對於具有雙折射特性的生物組織作量測,這是一般光學同調斷層掃描做不到的。這幾十年來,高膽固醇一直都是已開發國家威脅人們健康的主要原因之一,其中有報導指出過多的膽固醇累積在肝臟將會造成其發炎或是纖維化。所以在此論文中,我們利用偏振敏感式光學同調斷層掃描對於具有高膽固醇老鼠的肝臟做離體(in vitro)的量測,進而得到相位延遲(phase retardation),再進一步推算出雙折射(birefringence)的數值,證實高膽固醇老鼠的肝確實具有雙折射的特性有別於正常老鼠。

Development of biomedical imaging systems is an important issue for diagnosis applications. However, optical properties of biological tissues have not been well understood yet. We have measured transmitted signals with time-, aperture-, and angle-gating for comparison in micro-sphere suspension, chicken breast and chicken liver tissues. Although all the three gating methods might lead to effective biological imaging, they basically collected different portions of transmitted signals for imaging. For biological tissues of different structures, different gating methods might lead to different levels of imaging quality. It is worth exploring a most suitable gating method for a particular kind of tissue. ptical coherence tomography (OCT) has been applied to the scans of various portions of biological tissue, and used for the diagnosis of various diseases. In many situations, such as the pathological process in tissue, changes in the sample scattering property are so small that measurement is difficult. Therefore, for clinical applications, imaging contrast enhancement is an important issue. Polarization-sensitive optical coherence tomography (PSOCT) combines the depth resolution of OCT with polarization-dependent scanning to image the optical birefringence of biological tissues. In the past few decades, hypercholesterolemia has emerged to be a major health threat in the developed world. It has been reported that accumulation of excess cholesterol in the liver results in inflammation and fibrosis. We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with PSOCT. Tissue birefringence is evaluated through the measurement of phase retardation.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/188453
Appears in Collections:光電工程學研究所

Files in This Item:
File Description SizeFormat
ntu-98-D91941001-1.pdf23.32 kBAdobe PDFView/Open
Show full item record

Page view(s)

29
checked on Sep 25, 2023

Download(s) 5

21
checked on Sep 25, 2023

Google ScholarTM

Check

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback