https://scholars.lib.ntu.edu.tw/handle/123456789/136352
標題: | Distinct Rac Activation Pathways Control Caenorhabditis elegans Cell Migration and Axon Outgrowth | 作者: | Wu, Yi-Chun Cheng, Ting-Wen Lee, Ming-Chia Weng, Nei-Ying Wu, Chia-Hsuan Chen, Yi-Cheng Chen, Chin-Pei Chen, Li-Chyong Wu YC |
關鍵字: | Axon outgrowth; ced-10; ced-12; ced-2; ced-5; Cell migration; Guanine nucleotide exchange factor; mig-2; Rac; unc-73 | 公開日期: | 2002 | 卷: | 250 | 期: | 1 | 起(迄)頁: | 145-155 | 來源出版物: | Developmental Biology | 摘要: | Rac GTPases act as molecular switch in various morphogenic events. However, the regulation of their activities during the development of multicellular organisms is not well understood. Caenorhabditis elegans rac genes ced-10 and mig-2 have been shown to act redundantly to control P cell migration and the axon outgrowth of D type motoneurons. We showed that ced-10 and mig-2 also control amphid axon outgrowth and amphid dendrite fasciculation in a redundant fashion. Our biochemical and genetic data indicate that unc-73, which encodes a protein related to Trio-like guanine nucleotide exchange factor, acts as a direct activator of ced-10 and mig-2 during P cell migration and axon outgrowth of D type motoneurons and amphid sensory neurons. Furthermore, rac regulators ced-2/crkII and ced-5/dock180 function genetically upstream of ced-10 and mig-2 during axon outgrowth of D type motoneurons and act upstream of mig-2 but not ced-10 during P cell migration. However, neither ced-2/crkII nor ced-5/dock180 is involved in amphid axon outgrowth. Therefore, distinct rac regulators control ced-10 and mig-2 differentially in various cellular processes. © 2002 Elsevier Science (USA). |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/161410 http://ntur.lib.ntu.edu.tw/bitstream/246246/161410/1/03.pdf https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036392188&doi=10.1006%2fdbio.2002.0785&partnerID=40&md5=373a51016dfa7043ec96a9d424332476 |
ISSN: | 00121606 | DOI: | 10.1021/ja0570180 | SDG/關鍵字: | guanine nucleotide exchange factor; Rac protein; article; biochemistry; Caenorhabditis elegans; ced 10 gene; ced 5 gene; cell migration; controlled study; crkII gene; dock180 gene; gene; genetics; mig 2 gene; motoneuron; nerve fiber; nonhuman; priority journal; rac gene; unc 73 gene; Caenorhabditis; Caenorhabditis elegans |
顯示於: | 生命科學系 |
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