https://scholars.lib.ntu.edu.tw/handle/123456789/145769
標題: | Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study | 作者: | Hsu, Tai-Yi Shih, Hong-Mo Wang, Yu-Chiao Lin, Leng-Chieh GUAN-YI HE Chen, Chih-Yu Kao, Chia-Hung Chen, Chao-Hsien Chen, Wei-Kung Yang, Tse-Yen Cominelli, Fabio |
公開日期: | 2016 | 起(迄)頁: | e0165411 | 來源出版物: | PLoS ONE | 摘要: | Purpose ;This study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan. ;Methods ;This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (non-AI cohort). Each patient was monitored for 10 years to individually identify those who were subsequently diagnosed with Crohn disease (CD) and ulcerative colitis (UC) during the follow-up period. Cox proportional hazard regression analysis was conducted to determine the risk of IBD in patients with AI compared with controls without AI. ;Results ;The incidence rate of IBD during the 10-year follow-up period was 2.69 per 1 000 person-years and 0.49 per 1 000 person-years in the AI and non-AI cohorts, respectively. After adjustment for age, sex, and comorbidity, the AI cohort exhibited a 3.17-fold increased risk of IBD compared with the non-AI cohort (hazard ratio [HR] = 3.17, 95% confidence interval [CI] = 2.19-4.58). Compared with the non-AI cohort, the HRs of CD and UC were 4.40 and 2.33 for the AI cohort, respectively. After stratification for the severity of AI according to the duration of hospital stay, the adjusted HRs exhibited a significant correlation with the severity; the HRs of IBD were 1.76, 6.83, and 19.9 for patients with mild, moderate, and severe AI, respectively (p for the trend <.0001). ;Conclusion ;The risk of IBD was higher in patients with AI and increased with the length of hospital stay. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/279989 | DOI: | 10.1371/journal.pone.0165411 | SDG/關鍵字: | alcohol; adult; aged; alcohol consumption; alcohol intoxication; Article; cohort analysis; comorbidity; controlled study; Crohn disease; disease severity; drinking behavior; female; hazard ratio; hospitalization; human; incidence; inflammatory bowel disease; length of stay; major clinical study; male; medical service; national health insurance; observational study; randomized controlled trial; retrospective study; risk factor; risk reduction; Taiwan; ulcerative colitis; age; alcohol intoxication; complication; epidemiology; follow up; Inflammatory Bowel Diseases; middle aged; sex difference; Adult; Age Factors; Aged; Alcoholic Intoxication; Female; Follow-Up Studies; Hospitalization; Humans; Incidence; Inflammatory Bowel Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors; Taiwan |
顯示於: | 臨床醫學研究所 |
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