https://scholars.lib.ntu.edu.tw/handle/123456789/146060
標題: | Specific Stabilization of DNA Triple Helices by Indolo 2,1-B Quinazolin-6 ,12-Dione Derivatives | 作者: | CHEN, GRACE SHIA-HUY CHEN, HUI-TING LIN, SHWU-BIN CHERN, JI-WANG |
關鍵字: | DNA triplex;triplex stabilizing agents;tryptanthrin;indolo[2;1-b]quinazolin-6;12-dione;thermal denaturation | 公開日期: | 2007 | 卷: | v.17 | 期: | n.6 | 起(迄)頁: | 1769-1772 | 來源出版物: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 摘要: | Derivatives of indolo[2, 1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 degrees C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex. (c) 2006 Elsevier Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/89806 |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。