https://scholars.lib.ntu.edu.tw/handle/123456789/146082
標題: | A Kinetic-Dynamic Model for Regulatory Rna Processing | 作者: | Singh, Sher Yang, Hsiu-Yi Ou Chen, Mei-Ying Yu, Sung-Liang |
關鍵字: | kinetic-dynamic model;pre-mRNA splicing;FCEA;FC adaptive | 公開日期: | 2007 | 卷: | v.127 | 期: | n.3 | 起(迄)頁: | 488-495 | 來源出版物: | JOURNAL OF BIOTECHNOLOGY | 摘要: | A kinetic-dynamic model was proposed to simulate RNA processing by determining four essential reaction rates, including the rates of transcription, pre-mRNA turnover, pre -mRNA splicing, and mRNA decay. A family competition evolutionary algorithm (FCEA) was adapted herein to approximate these rates. Several artificial datasets were used to verify the correctness and robustness of the FCEA. The model was finally applied on time series data of yeast prp4-1 mutant cells for determination of rates of RNA processing. Based on the FCEA, the model indicated that the pre-mRNA splicing was decreased in the mutant cells as well as the possible effects on transcription, pre-mRNA turnover, and mRNA decay, which was consistent with surveyed literature. (c) 2006 Elsevier B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/89828 |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。