https://scholars.lib.ntu.edu.tw/handle/123456789/146113
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 醫學檢驗暨生物技術學系 | en |
dc.contributor.author | YANG, YA-CHIEN | en |
dc.contributor.author | HSU, TSUEY-YING | en |
dc.contributor.author | CHEN, JEN-YANG | en |
dc.contributor.author | YANG, CZAU-SIUNG | en |
dc.contributor.author | LIN, RONG-HWA | en |
dc.creator | 楊雅倩;許翠瑛;陳振陽;楊照雄;林榮華 | zh-tw |
dc.creator | YANG, YA-CHIEN;HSU, TSUEY-YING;CHEN, JEN-YANG;YANG, CZAU-SIUNG;LIN, RONG-HWA | en |
dc.date | 2001 | en |
dc.date.accessioned | 2009-01-20T16:21:03Z | - |
dc.date.accessioned | 2018-07-06T08:09:51Z | - |
dc.date.available | 2009-01-20T16:21:03Z | - |
dc.date.available | 2018-07-06T08:09:51Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/105268 | - |
dc.description.abstract | Cord blood T cells are much more likely to be induced to apoptosis in vitro than adult T cells. Nevertheless, the expression of Fas is markedly lower on cord blood lymphocytes than on peripheral blood lymphocytes. In the current investigation, we determined the capacity of tumour necrosis factor-alpha (TNF-alpha) to induce apoptosis in human naive T cells in cord blood, and assessed the roles of two distinct TNF receptors (TNFRs) in mediating death signals. After activation, cord blood T cells were sensitive to TNF-alpha -induced apoptosis, and interleukin 2 (IL-2) could prevent this apoptotic response. Both TNFR1 (p55) and TNFR2 (p75) expressed on activated cord blood T cells were able to transmit apoptotic signals. Moreover, a synergistic effect was observed by a combination of TNFR1- and TNTFR2- signals. Additionally, CD4(+) T cells showed higher sensitivity to TNTR-mediated apoptosis than CD8(+) T cells. These data suggest that TNF-alpha probably is a mediator of apoptosis in cord blood T cells in vivo and may contribute to the low incidence of graft-versus- host disease in cord blood transplantation. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BRITISH JOURNAL OF HAEMATOLOGY v.115 n.2 pp.435-441 | en |
dc.relation.ispartof | BRITISH JOURNAL OF HAEMATOLOGY | - |
dc.subject | cord blood | en |
dc.subject | T cells, apoptosis | en |
dc.subject | TNFR1 | en |
dc.subject | TNFR2 | en |
dc.subject | VERSUS-HOST DISEASE | en |
dc.subject | UNRELATED DONORS | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Tumour Necrosis Factor-Alpha-Induced Apoptosis in Cord Blood T Lymphocytes: Involvement of Both Tumour Necrosis Factor Receptor Types 1 and 2 | en |
dc.relation.pages | 435-441 | - |
dc.relation.journalvolume | v.115 | - |
dc.relation.journalissue | n.2 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學檢驗暨生物技術學系 |
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