https://scholars.lib.ntu.edu.tw/handle/123456789/160005
標題: | DAPK功能機制與訊息網路之研究(1/5) | 作者: | 陳瑞華 Chen, Ruey-Hwa |
關鍵字: | anoikis;DAPK;death domain/ERK | 公開日期: | 26-五月-2005 | 出版社: | 臺北市:國立臺灣大學醫學院分子醫學研究所 | 摘要: | Death-associated protein kinase (DAPK) is a death domain-containing serine/threonine kinase, and participates in various apoptotic paradigms. Here, we identify the extracellular signal-regulated kinase (ERK) as a DAPK-interacting protein. DAPK interacts with ERK through a docking sequence within its death domain and is a substrate of ERK. Phosphorylation of DAPK at Ser 735 by ERK increases the catalytic activity of DAPK both in vitro and in vivo. Conversely, DAPK promotes the cytoplasmic retention of ERK, thereby inhibiting ERK signaling in the nucleus. This reciprocal regulation between DAPK and ERK constitutes a positive feedback loop that ultimately promotes the apoptotic activity of DAPK. In a physiological apoptosis system where ERK-DAPK interplay is reinforced, downregulation of either ERK or DAPK suppresses such apoptosis. These results indicate that bi-directional signalings between DAPK and ERK may contribute to the apoptosis-promoting function of the death domain of DAPK. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/23788 | 其他識別: | 932321B002017 | Rights: | 國立臺灣大學醫學院分子醫學研究所 |
顯示於: | 分子醫學研究所 |
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