DC Field | Value | Language |
dc.contributor.author | 陳瑞華 | zh_TW |
dc.contributor.author | Chen, Ruey-Hwa | en |
dc.creator | 陳瑞華 | zh_TW |
dc.creator | Chen, Ruey-Hwa | en |
dc.date | 2005-05-26 | zh_TW |
dc.date.accessioned | 2006-07-26T03:26:50Z | - |
dc.date.accessioned | 2018-07-09T01:13:38Z | - |
dc.date.available | 2006-07-26T03:26:50Z | - |
dc.date.available | 2018-07-09T01:13:38Z | - |
dc.date.issued | 2005-05-26 | - |
dc.identifier | 932321B002017 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/23788 | - |
dc.description.abstract | Death-associated protein kinase (DAPK) is a death domain-containing serine/threonine
kinase, and participates in various apoptotic paradigms. Here, we identify the extracellular
signal-regulated kinase (ERK) as a DAPK-interacting protein. DAPK interacts with ERK
through a docking sequence within its death domain and is a substrate of ERK.
Phosphorylation of DAPK at Ser 735 by ERK increases the catalytic activity of DAPK both
in vitro and in vivo. Conversely, DAPK promotes the cytoplasmic retention of ERK,
thereby inhibiting ERK signaling in the nucleus. This reciprocal regulation between DAPK
and ERK constitutes a positive feedback loop that ultimately promotes the apoptotic activity
of DAPK. In a physiological apoptosis system where ERK-DAPK interplay is reinforced,
downregulation of either ERK or DAPK suppresses such apoptosis. These results indicate
that bi-directional signalings between DAPK and ERK may contribute to the
apoptosis-promoting function of the death domain of DAPK. | en |
dc.format | application/pdf | zh_TW |
dc.format.extent | 417030 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院分子醫學研究所 | zh_TW |
dc.rights | 國立臺灣大學醫學院分子醫學研究所 | zh_TW |
dc.subject | anoikis | en |
dc.subject | DAPK | en |
dc.subject | death domain/ERK | en |
dc.title | DAPK功能機制與訊息網路之研究(1/5) | zh_TW |
dc.type | journal article | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/23788/1/932321B002017.pdf | - |
dc.coverage | 計畫年度:93;起迄日期:2004-08-01/2005-07-31 | zh_TW |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | zh_TW | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
Appears in Collections: | 分子醫學研究所
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