https://scholars.lib.ntu.edu.tw/handle/123456789/160053
標題: | Decreased Serum Ige Level, Decreased Ifn-Gamma and Il-5 but Increased Il- 10 Production, and Suppressed Cyclooxygenase 2 Mrna Expression in Patients with Perennial Allergic Rhinitis after Treatment with a New Mixed Formula of Chinese Herbs | 作者: | YU, CHIA-LI | 關鍵字: | allergic rhinitis;mixed formula of Chinese herbs;IgE;interleukin 10;interleukin 5;interferon-gamma | 公開日期: | 2001 | 卷: | v.1 | 期: | n.6 | 起(迄)頁: | 1173-1182 | 來源出版物: | INTERNATIONAL IMMUNOPHARMACOLOGY | 摘要: | A new mixed formula of Chinese herbs containing Shin-yi-san + Xiao-qing- long-tang + Xiang-sha-liu-jun-zi-tang by the weight of 9 + 3 + 3 g/day was prescribed for the treatment of patients with perennial allergic rhinitis for 3 months ( the composition of each herb is shown in the tables of the article). We classified the patients into high (H-IgE) and low IgE (L-IgE ) groups according to the titer of serum total IgE (> 200 KIU/l in H-IgE vs. < 200 KIU/l in L-IgE) and the presence of house dust mite-specific IgE . The nasal symptomatic score in the high IgE group was significantly improved from 7.19 +/- 0.18 before treatment to 2.67 +/- 0. 37 after treatment. In addition, the serum total and house dust mite-specific IgE level were also decreased after treatment. For elucidating the working mechanism of the mixed formula, the Th1 (IFN-gamma) and Th2 (IL-4, IL-5, IL- 10 and IL-13) cytokine production by phytohemagglutinin (PHA )- stimulated mononuclear cells (2 X 10(6) cells/ml) and cyclooxygenase type 2 (COX-2) mRNA expression in LPS or IL- 13-stimulated PMN were compared before and after 3 months of treatment. We found that the mixed formula treatment significantly enhanced IL-10 but decreased IFN-gamma and IL- 5 production by PHA-stimulated mononuclear cells. The IL-5 production was also decreased by PHA-stimulated lymphocyte. In addition, the COX-2 mRNA expression in stimulated PMN was significantly suppressed after treatment. These results suggest that the new mixed formula treatment is beneficial to the patients with perennial allergic rhinitis via modulating the function of lymphocytes and neutrophils. (C) 2001 Elsevier Science B.V. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/95056 |
顯示於: | 分子醫學研究所 |
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