https://scholars.lib.ntu.edu.tw/handle/123456789/160276
DC Field | Value | Language |
---|---|---|
dc.contributor | 臺大醫學院-分子醫學研究所;臺大醫學院-免疫學研究所; | - |
dc.contributor.author | Lai, Ming-Zong | en |
dc.contributor.author | Chen, Ruey-Hwa | en |
dc.creator | Lai, Ming-Zong;Chen, Ruey-Hwa | en |
dc.creator | 賴明宗;陳瑞華 | zh-tw |
dc.date | 2014 | - |
dc.date.accessioned | 2017-05-25T05:27:02Z | - |
dc.date.accessioned | 2018-07-09T01:23:51Z | - |
dc.date.available | 2017-05-25T05:27:02Z | - |
dc.date.available | 2018-07-09T01:23:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/278919 | - |
dc.description.abstract | Death-associated protein kinase (DAPK) is a tumor suppressor and negatively regulates several activation signals. Consistent with its potential anti-inflammatory activity, DAPK promotes the formation of IFN-gamma-activated inhibitor of translation (GAIT) complex that suppresses the translation of selected inflammatory genes. DAPK has been found to inhibit tumor necrosis factor-alpha (TNF-alpha)- or lipopolysaccharides (LPS)-induced NF-kappa B activation and pro-inflammatory cytokine expression. Inflammation is always associated with T cell activation, while DAPK attenuates T cell activation by a selective suppression in T cell receptor-triggered NF-kappa B activation. Recent studies, however, also reveal a contribution of DAPK to pro-inflammatory processes. DAPK is shown to mediate pro-inflammatory signaling downstream of TNF-alpha, LPS, IL-17, or IL-32. In addition, DAPK is required for the full formation of NLRP3 inflammasome, essential for the generation of IL-1 beta and IL-18. These results suggest the complicated role of DAPK in the regulation of inflammation that is likely dependent on cell types and environmental cues. | - |
dc.language | en-us | - |
dc.relation | Apoptosis, 19(2), 357-363 | - |
dc.relation.ispartof | APOPTOSIS | en_US |
dc.subject | DAPK | - |
dc.subject | Inflammation | - |
dc.subject | TNF-alpha | - |
dc.subject | T cell activation | - |
dc.subject | NF-kappa B | - |
dc.subject | Inflammasome | - |
dc.title | Regulation of inflammation by DAPK | - |
dc.identifier.doi | 10.1007/s10495-013-0933-4 | - |
dc.relation.pages | 357-363 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | 分子醫學研究所 |
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