https://scholars.lib.ntu.edu.tw/handle/123456789/160549
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 免疫學研究所 | en |
dc.contributor.author | CHOU, AI-HSIANG | en |
dc.contributor.author | HSU, PING-NING | en |
dc.creator | 周愛湘;許秉寧 | zh-tw |
dc.creator | CHOU, AI-HSIANG;HSU, PING-NING | en |
dc.date | 2001 | en |
dc.date.accessioned | 2008-12-05T01:12:54Z | - |
dc.date.accessioned | 2018-07-09T01:48:48Z | - |
dc.date.available | 2008-12-05T01:12:54Z | - |
dc.date.available | 2018-07-09T01:48:48Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/87877 | - |
dc.description.abstract | TNF-related apoptosis-inducing ligand (TRAIL, also called Apo2L), a novel member of TNF superfamily, induces apoptosis in transformed cell lines of diverse origin. TRAIL is expressed in most of the cells, and the expression is up- regulated in activated T cells. Four receptors for TRAIL have been identified, and there is complex interplay between TRAIL and TRAIL receptors in vivo. The actual biological function of TRAIL/TRAIL receptor is still not clear. Growing evidence has demonstrated that members of TNF superfamily transduce signals after engagement with their receptors. Cross-linking of TRAIL by plate-bound rTRAIL receptor, death receptor 4-Fc fusion protein enhanced T cell proliferation and increased IFN- production in conjunction with immobilized suboptimal anti-CD3 stimulation in mouse splenocytes. The increase of T cell proliferation by death receptor 4-Fc was dose dependent, and this effect could be blocked by soluble rTRAIL proteins, indicating the occurrence of reverse signaling through TRAIL on T cell. The enhanced secretion of IFN- mediated via TRAIL could be blocked by SB203580, a p38 mitogen-activated protein kinase - specific inhibitor. Thus, in addition to its role in inducing apoptosis by binding to the death receptors, TRAIL itself can enhance T cell proliferation after TCR engagement and signal the augmentation of IFN- secretion via a p38- dependent pathway. This provides another example of reverse signaling by a member of TNF superfamily. In conclusion, our data suggest that TRAIL can itself transduce a reverse signal, and this may shed light on the biological function of TRAIL. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | Journal of Immunology v.167 pp.1347 | en |
dc.relation.ispartof | Journal of Immunology | - |
dc.title | Enhanced Proliferation and Increased Interferon-g Production in T Cells by Signal Transduced Through Tumor Necrosis Factor -Related Apoptosis- Inducing Ligand (TRAIL) | en |
dc.relation.pages | 134-7 | - |
dc.relation.journalvolume | v.167 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 免疫學研究所 |
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