DC 欄位 | 值 | 語言 |
dc.contributor | 免疫學研究所 | en |
dc.contributor.author | CHOU, WEI-CHUN | en |
dc.contributor.author | LEE, CHIEN-KUO | en |
dc.contributor.author | 周威君 | zh |
dc.contributor.author | 李建國 | zh |
dc.creator | 周威君;李建國 | zh |
dc.creator | CHOU, WEI-CHUN;LEE, CHIEN-KUO | en |
dc.date | 2006-11 | - |
dc.date.accessioned | 2011-04-29T04:00:16Z | - |
dc.date.accessioned | 2018-07-09T01:57:00Z | - |
dc.date.available | 2011-04-29T04:00:16Z | - |
dc.date.available | 2018-07-09T01:57:00Z | - |
dc.date.issued | 2006-11 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/233064 | - |
dc.description.abstract | Transcription factors are critical for instructing the development of B lymphocytes from multipotential progenitor cells in the bone marrow (BM). Here, we show that the absence of STAT3 impaired B-cell development. Mice selectively lacking STAT3 in BM progenitor cells displayed reduced numbers of mature B cells, both in the BM and in the periphery. The reduction in the B-cell compartment included reduced percentages and numbers of pro-B, pre-B, and immature B cells in the absence of STAT3, whereas the number of pre-pro-B cells was increased. We found that pro-B and pre-B-cell populations lacking STAT3 were hyporesponsive to IL-7 because of a decreased number of IL-7-responsive cells rather than decreased expression or signaling of IL-7R alpha . Moreover, STAT3-deficient mice displayed enhanced apoptosis in the pro-B population when deprived of survival factors, suggesting that at least 2 mechanisms (impaired differentiation and enhanced apoptosis) are involved in the mutant phenotype. Last, BM transplantation confirmed that impaired B lymphopolesis in the absence of STAT3 was caused by a cell autonomous defect. In sum, these studies defined a specific role for STAT3 in early B-cell development, probably acting at the pre-pro-B transition by contributing to the survival of IL-7-responsive progenitors. | en |
dc.format.extent | 371739 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh_TW | en |
dc.language.iso | en_US | - |
dc.relation | Blood,108(9),3005-3011 | en |
dc.relation.ispartof | Blood | en_US |
dc.title | STAT3 positively regulates an early step in B cell development | en |
dc.relation.pages | 3005-3011 | - |
dc.relation.journalvolume | 108 | - |
dc.relation.journalissue | 9 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/233064/1/Blood 2006.pdf | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en_US | - |
顯示於: | 免疫學研究所
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