https://scholars.lib.ntu.edu.tw/handle/123456789/161745
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 臺大醫院;臺大醫院-神經部;臺大醫院-麻醉部;臺大醫院-精神醫學部;臺大醫學院;臺大醫學院-腦與心智科學研究所; | - |
dc.contributor.author | Hsu, Yen-Hsuan | en_US |
dc.contributor.author | FENG-SHENG LIN | en_US |
dc.contributor.author | Yang, Chi-Cheng | en_US |
dc.contributor.author | CHIH-PENG LIN | en_US |
dc.contributor.author | Hua, Mau-Sun | en_US |
dc.contributor.author | WEI-ZEN SUN | en_US |
dc.creator | Hsu, Yen-Hsuan;Lin, Feng-Sheng;Yang, Chi-Cheng;Lin, Chih-Peng;Hua, Mau-Sun;Sun, Wei-Zen | en |
dc.creator | 孫維仁;林峰盛;花茂棽;林至芃 | zh-tw |
dc.date | 2015 | - |
dc.date.accessioned | 2017-05-31T10:06:04Z | - |
dc.date.accessioned | 2018-07-09T03:44:51Z | - |
dc.date.available | 2017-05-31T10:06:04Z | - |
dc.date.available | 2018-07-09T03:44:51Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/279256 | - |
dc.description.abstract | Background/Purpose: Midazolam is a widely used sedative agent during colonoscopy, with cognitive toxicity. However, the potential cognitive hazard of midazolam-based light sedation has not been sufficiently examined. We aimed to examine the cognitive safety and vulnerability profile under midazolam light sedation, with a particular focus on individual variations. Methods: We conducted a prospective case-controlled study in an academic hospital. In total, 30 patients undergoing sedative colonoscopy as part of a health check-up were recruited. Neuropsychological testing on the full cognitive spectrum was evaluated at 15 minutes and 120 minutes after low-dose midazolam administration. The modified reliable change index (RCI) was used for intrapersonal comparisons and controlling for practice effects. Results: Midazolam affected psychomotor speed (48%), memory (40%), learning (32%), working memory (17%), and sustained attention (11%), while sparing orientation and the fluency aspect of executive function at the acute stage. Residual memory (10%) and learning (10%) impairments at 2 hours after administration were evidenced in some patients. The three object recall and digit symbol coding tests can serve as useful screening tools. Conclusion: Midazolam-based light sedation induced selective cognitive impairments and prolonged cognitive impairments occurred in patients with advanced age. A longer observation time and further screening were recommended for patients due to their at risk state. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved. | en_US |
dc.language | en-us | - |
dc.relation | J. Formos. Med. Assoc., 114(6), 489-497 | en_US |
dc.relation.ispartof | Journal of the Formosan Medical Association | en_US |
dc.subject | cognitive function | en_US |
dc.subject | endoscopy | en_US |
dc.subject | midazolam | en_US |
dc.subject | reliable change index | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | midazolam; hypnotic sedative agent; intravenous anesthetic agent; midazolam; adult; age distribution; annoyance; anxiety; Article; assessment of humans; attention; clinical article; cognition; cognitive defect; colonoscopy; controlled study; drug dose titration; drug safety; executive function; fatigue; female; human; learning; light sedation; low drug dose; male; middle aged; motivation; neuropsychological test; orientation; prospective study; psychomotor performance; reliable change index; sedation; university hospital; working memory; case control study; chemically induced; cognition; Cognition Disorders; psychological rating scale; regression analysis; short term memory; Taiwan; Anesthetics, Intravenous; Attention; Case-Control Studies; Cognition; Cognition Disorders; Colonoscopy; Female; Humans; Hypnotics and Sedatives; Learning; Male; Memory, Short-Term; Midazolam; Middle Aged; Neuropsychological Tests; Prospective Studies; Psychiatric Status Rating Scales; Regression Analysis; Taiwan | - |
dc.title | Evident cognitive impairments in seemingly recovered patients after midazolam-based light sedation during diagnostic endoscopy | en_US |
dc.identifier.doi | 10.1016/j.jfma.2013.07.018 | - |
dc.identifier.doi | 10.1016/j.jfma.2013.07:018 | - |
dc.relation.pages | 489-497 | en_US |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology | - |
crisitem.author.dept | Anesthesiology-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Medical Device and Imaging | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.orcid | 0000-0003-2928-3203 | - |
crisitem.author.orcid | 0000-0001-8543-2600 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
顯示於: | 腦與心智科學研究所 |
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